Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"hippocampal function"”.
-
GPR30: a role for a novel estrogen-sensing receptor in hippocampal function?
… class, the estrogens, is a known regulator of hippocampal function and is capable of being synthesised within hippocampal neurons. E2 can modulate glutamatergic synaptic transmission and hippocampal synaptic plasticity, as well as enhance hippocampal dependent learning in rodent models. …
-
Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals: A feasibility study
… exercise improves the ability of the brain to function. It can even lead to new cell formation in a part of the brain called the hippocampus, which is important for memory processing. This study is investigating whether exercise may also improve hippocampal function in depressed humans. One way …
-
Viral delivery of recombinant growth hormone to rescue effects of chronic stress on hippocampal learning
… the nature of stress-induced impairment of hippocampal function and determine whether infusion of a modified herpes simplex virus (HSV) carrying the recombinant rodent growth hormone (GH) would be sufficient to restore normal hippocampal function. After 21 days of chronic immobilization …
-
The impact of lifestyle factors and development on relational memory
… is the hippocampus, and tasks that assess hippocampal function are ideally positioned for use in exercise and nutrition interventions, particularly early in life when these interventions may have the greatest benefit. While the hippocampus has historically been viewed as the heart of the …
-
Studies on the effect of growth hormone on age-related changes in glutamatergic transmission in the hippocampus
… in cognitive processing and maintenance of hippocampal function. Hippocampal function is mediated primarily by the AMPA and NMDA glutamatergic receptors, and these receptors are important for the basal synaptic transmission and long term potentiation (LTP) that underlie learning and memory …
-
Investigating the role of interleukin-6 in neuronal dysfunction in the mdx mouse model of Duchenne muscular dystrophy
… However, it is apparent that dystrophin not only functions in skeletal muscle, but in the CNS as well, with an increased incidence of cognitive impairment and deficits in verbal, short-term and working memory in individuals with DMD. The hippocampus is critical for learning and the formation and …
-
Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… with disturbances in mood and cognitive function. To determine the biological basis of these behavioral changes, researchers have concentrated on the hippocampal formation, a medial temporal lobe structure involved in the regulation of mood and cognition in humans. It is now clear that …
-
Spatial representation from birth to old age: Insights from comparative neurobiology and behavioral genomics.
… actions. However, despite the importance in its function, the hippocampus is also one of the first areas of the brain to be affected by aging and other neurological disorders. The present thesis used the help of various animal models to answer three questions: first whether hippocampal function …
-
Development of new methods to investigate the role of the avian hippocampus in memory formation in brown-headed cowbirds
… known to participate in a variety of cognitive functions in humans, non-human primates, rodents, and birds. A great deal of previous research on the avian hippocampus has examined its role in spatial memory. A question regarding avian hippocampal function that remains unanswered is, what is its …
-
Measuring Memory in an Alzheimer's Treatment Trial Using a Visual Search Task
… memory deficits attributed to damage to the hippocampal formation. AD therapies specifically targeting hippocampal function may be best evaluated through the use of selective hippocampal tasks. I used a nonverbal hippocampal-dependent target-in-scene detection task to determine if task …
-
Associative and Error-Driven Learning in Younger and Older Adults
… & Bar-On 2003) that are related to decreases in hippocampal function (Driscoll et al., 2003; Mitchell, Johnson, Raye, & D’Esposito, 2000). However, older adults learn certain simple predictive relationships between events (Mutter & Williams, 2004) that involve basal ganglia dependent error-driven …
-
Transitive inference in healthy humans and implications for schizophrenia
… AE, animal experiments demonstrated that intact function of the hippocampus is necessary for TI but not for non-TI. We performed three functional magnetic resonance imaging (fMRI) experiments to identify neural correlates of TI in healthy humans. First, we show hippocampal activation in learning …
-
Memory Performance in Children with Temporal Lobe Epilepsy: Neocortical vs. Dual Pathologies
… lobe epilepsy and the ability to discern hippocampal dysfunction with conventional memory tests that are typically used to detect more global memory impairment. All data was obtained retrospectively from the epilepsy surgery program at a local children’s hospital. The research population …
-
Neural mechanisms involved in memory formation and retrieval within the rodent hippocampus : an in vivo electrophysiological study
… pharmacological and genetic manipulations of hippocampal function in order to investigate how the cellular and network properties of the hippocampus contribute to memory storage and retrieval. In Part I of this thesis, extracellular recordings are used to monitor systematic changes in the …
-
The Neural Correlates of Allocentric Spatial Memory in Schizotypy
… using the Schizotypal Personality Questionnaire. Functional and structural MRI was used to investigate the neural correlates of allocentric spatial memory in schizotypal personality. Allocentric spatial memory is reported to be impaired in schizophrenia and this is thought to be related to …
-
ANATOMICAL AND ELECTROPHYSIOLOGICAL STUDIES OF AN ANIMAL MODEL OF TEMPORAL LOBE EPILEPSY WITH CLASSIC HIPPOCAMPAL SCLEROSIS
… exhibiting a characteristic pattern of hippocampal neuron loss called "classic hippocampal sclerosis." No single injury has reproduced this extensive neuron loss experimentally, suggesting that hippocampal sclerosis may be an "endstage" pathology caused by an initial insult plus years of …
-
Assessing the role of the hippocampus in amygdala kindled fear : an analysis of environmental habituation
… if the rats displayed impairments in this hippocampal-dependent function. In Experiment 1, long-term kindled rats demonstrated consistently elevated exploration and fear over repeated exposure to an initially novel open field, indicating impaired habituation. In Experiment 2, all kindled …
-
Genetic and behavioral discrimination of dopamine 1 and 5 receptors in hippocampal dependent memory consolidation
… the brain, but very little is known how dopamine functions in hippocampal dependent learning. It was only until recently that dopamine-containing neurons were found to project to the hippocampus. Even less understood are the expression patterns of DA receptors within the hippocampus and this is …
-
Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
… effects of prenatal PGE2 exposure on hippocampal electrophysiology in the C57bl/6 mice offspring at postnatal day 90-100. I measured Schaffer collateral long-term potentiation (LTP), paired-pulse facilitation (PPF), input/output (I/O) responses, the expression of glutamate receptor …
Page 1 of 2