Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"hippo"”.
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Studies of the Hippo Signaling Pathway
… been identified as a genetic modifier for the Hippo signaling pathway. However, the exact mechanism by which this complex regulates the Hippo signaling pathway need to be further addressed.
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Augustine of Hippo: On Justification by Faith
<p>This study aims to retrieve Augustine of Hippo’s view of ‘justification by faith’ from his theological writings from the 390s to the end of his career. Significant sources are his early, unfinished commentaries on Paul’s letters to the Romans and his completed commentary on Galatians. In these, …
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Genetic Analysis of The Hippo Pathway In Mouse Liver
… genes in <em>Drosophila</em> revealed the Hippo-signaling pathway as a kinase cascade consisting of five core components. Disrupting the pathway by deleting the main component genes breaks the balance of cell proliferation and apoptosis and results in epithelial tissue tumorigenesis. The …
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Cell Polarity Regulates Organ Growth Through The Hippo Pathway
… of function cause overgrowth and induction of Hippo target genes. In addition, Crumbs is required for the proper localization of Expanded, an upstream component of the Hippo pathway. Furthermore, we uncoupled the cell polarity and growth control function of Crb through structure-functional …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… The loss of Merlin function causes augmented Hippo signaling i.e. interaction of YAP and TAZ, both co-activators of gene expression and the two main effectors of the Hippo signalling pathway, and TEAD, a group of transcription factors binding to YAP and TAZ. There resulting gene expression is …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
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Genetic modeling of the Hippo pathway in hematopoietic stem cells
… aim of this thesis was to study the role of the Hippo signaling pathway in HSCs. The Hippo pathway is a newly discovered signaling pathway, which regulates organ size in Drosophila. Hippo signaling has further been implicated in regulation of mammalian stem cells. In Article I we developed a new …
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Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
… developmental and homeostatic processes. The Hippo pathway is a major regulator of tissue growth and organ size. Hippo and TGFβ pathways are intimately interconnected. Hippo pathway mediators Taz/Yap interact with the TGFβ regulated Smads and when Hippo is activated, the cytoplasmically …
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Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
<p>The highly conserved Hippo kinase cascade is critical for both regulation of organ size in development and tumor suppression. Several mechanisms, such as cell-cell contact in vitro and organ size in vivo, have been implicated in the activation of the Hippo pathway, leading to inactivation of the …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… revealed frequent mutations in components of the Hippo/Warts pathway, a highly conserved regulator of genes controlling proliferation and apoptosis which is frequently dysregulated in cancer. Here, I describe the generation and characterization of a GEMM which gives rise to metastatic sRCC: …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… of meningiomas and schwannomas respectively. The Hippo pathway is an evolutionarily conserved pathway that has been shown to control tissue size by contactmediated growth inhibition. Previous studies have shown that there is aberrant nuclear activity of yes-associated protein (YAP) and …
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Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
The Hippo pathway is an evolutionarily conserved signaling cascade and comprises the core Hippo kinases MST1/2 and LATS1/2, which phosphorylate the transcriptional YES associated protein (YAP), promoting its nuclear exclusion and degradation. Excess YAP activity is oncogenic and is commonly …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
… Hedgehog signaling and the Wnt SLiM to mediate Hippo signaling during infection to prevent intrinsic apoptosis. We demonstrate the activation of Hedgehog and Hippo transcription factor and co-activator Gli-1 and Yap through the interaction of TRP120 with Hedgehog and Hippo receptors during …
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Adherens Junctions and The Actomyosin Network Regulate Organ Growth By Modulating Hippo Pathway Activity In Drosophila
… the downstream transcriptional effector of the Hippo pathway. Importantly, it is unclear if AJ and basolateral components act through the same or parallel mechanisms to regulate Yorkie activity.</p> <p>Here, we dissect how loss of AJ and basolateral components affects Hippo signaling in …
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Eloquent Wisdom: The Role of Rhetoric and Delight in the Theology of Saint Augustine of Hippo
This study examines Augustine’s conception of the role of delight (delectatio) in the divine acts of creation and redemption. In the first part of the dissertation, I argue that Augustine, who was trained as a rhetor and taught rhetoric before his conversion, came to conceive of theology as the …
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Aspects of the spatial and behavioural ecology of Hippopotamus amphibious in the Saint Lucia Estuary, KwaZulu-Natal, South Africa
The common hippopotamus (Hippopotamus amphibius) is endemic to Africa but threatened by range restriction, exploitation and competition with humans and domestic livestock for access to critical resources such as fresh water and grazing. Collectively these impacts have resulted in population …
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Terrestrial-aquatic transfers by hippopotamus (Hippopotamus amphibius): effects on food web and benthic community structure of the St Lucia Estuary, iSimangaliso Wetland Park, World Heritage Site, South Africa
Africa’s last extant aquatic megaherbivore, the hippopotamus, facilitates linkages between terrestrial and aquatic systems at scales, frequencies and intensities that are probably unmatched by any other natural process. Through defaecation of terrestrial grasses into aquatic habitats, hippos …
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The inhibition of mammary epithelial cell growth by the long isoform of Angiomotin
… of the tumor suppressor protein kinases of the Hippo pathway. Canonically, Hippo protein kinases inhibit cellular growth through the phosphorylation and inactivation of the oncogenic transcriptional co-activator Yes-Associated Protein (YAP). This study defines an alternative mechanism whereby …
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Hippopotami in a liminal space: a multi-species ethnography of Lake Tanganyika in Bujumbura
… daily life and interactions between humans and hippopotami (hippo). Societal development agendas have favoured economic growth and infrastructural development with little regard for the well-being of multi-species communities. The study contrasts the ideas that drive economy-based approaches to …
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