Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"hindlimb ischemia"”.
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Molecular imaging of spatio-temporal distribution of angiogenesis in hindlimb ischemia model and diabetic milieu
… of the endogenous angiogenic response to ischemia was perfomed. After vascular occlusion, ischemic angiogenesis is an important reparative mechanism and can ameliorate the outcome of ischemic disease. Diabetic foot ulcers affect almost 15% of diabetic patients and are the leading cause of …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… as atherosclerosis or diabetes. Critical limb ischemia (CLI) is a severe form of PAD associated with high morbidity and mortality. Currently, no effective and permanent treatments are available for this disease. The current endovascular medications (e.g., angioplasty or stents) only relieve the …
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Functional particles for controlled release and cell surface engineering
… of these particle platforms in the treatment of hindlimb ischemia associate with chronic kidney disease (Chapter 4) and the delivery of CD44-binding particles for enhanced retention in aged mice associated with Alzheimer’s disease (Chapter 5). Overall, these studies present a deeper understanding …
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Oxygen Generating Materials for Tissue Restoration and Regeneration
… vivo</italic> was performed in a rat model of hindlimb ischemia, creating an oxygen deficit in the leg muscles. Short-term functional and histological assessments established the effectiveness of the material in an environment with little to no vascular supply, which would normally become …
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Vascular calcification as a risk factor for peripheral arterial disease and its effects on angiogenesis
… continues to put patients at constant risk of ischemia; increasing their risk of developing limb amputations which subsequently affects their quality of life. Therapies for PAD are centred around alleviating stenosis and promoting tissue revascularization following ischemia, and while …
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Major Collateral Vessels Develop from Pre-existing Small Arteries through RAC2/NOX2 Independent Mechanisms
… arterial occlusion in the pig, rat, and mouse hindlimbs for comparison to humans. Pre-existent small named arteries enlarged ~2-3-fold to become the major collateral vessels in each species, these major collaterals displayed characteristics similar to large arteries experiencing flow-mediated …