Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"hindered diffusion"”.
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Modeling of controlled-release drug delivery from autocatalytically degrading polymer microspheres
… diffusivity of the drug. A mechanistic reaction-diffusion model with pore evolution coupled to hydrolysis and related to the effective diffusivity through hindered diffusion theory is proposed. Experimental background motivating the attention to the size-dependent effects of autocatalysis on drug …
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Improving the delivery and efficacy of molecular medicine via extracellular matrix modulation : insights from intravital microscopy
… presence of fibrillar collagen correlated with hindered diffusion in vivo, and also in vitro, in collagen gels prepared to mimic tumor extracellular matrix. Modification of the tumor collagen matrix directly with purified bacterial collagenase, or indirectly with relaxin treatment, resulted in …
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Dynamics of Nanoparticles in Complex Media
Hindered mobility of nanoparticles in complex media is ubiquitous in drug delivery, in processing of polymer nanocomposites, and in extraction of hydrocarbons. These applications require nanoparticles suspended in non-Newtonian fluids to be controllably dispersed through complex porous media. In …
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Microfluidic synthesis and properties of bio-inspired colloids
… previously unattainable particle sizes. Brownian diffusion of colloidal discs in bulk suggests the out-of-plane dimension can be as small as 0.8 [mu]m, which agrees with confocal microscopy measurements. We measure the hindered diffusion of microdiscs near a solid interface and compared our …
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Investigation of protein destabilization in monodisperse poly(lactide-co-glycolide) microparticles
… The degradation process of PLG microspheres and hindered diffusion of acidic by-products cause the formation of a pH gradient from the surface to the core of the particles, which autocatalyzes the PLG degradation reaction. This phenomenon drives the relationship between microsphere diameter and …