Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"hindbrain"”.
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Neuromeric organization of the midbrain-hindbrain boundary region in zebrafish
… compartments. The units of the vertebrate hindbrain, the rhombomeres, serve as the best-studied examples of neuromeres. Here, the lineage restriction mechanism has been found to function on the basis of differentially expressed adhesion molecules. To date, hard evidence for the existence of …
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Studies of the hindbrain roof plate organiser in the chick embryo
… certain anteroposterior locations, such as the hindbrain, it is expanded to form a thin epithelium that tents over a ventricle. Using chick embryos, I have investigated a hypothesis that reconciles the roof plate with this emergent model, in which the organiser properties of the roof plate are …
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Plxna4 and its role in neuronal survival in the developing zebrafish hindbrain
… early in development, and localizes to the hindbrain as neurogenesis and differentiation proceed. In the hindbrain of a plxna4-/- CRISPR mutant, expression of the Islet transcription factor by cranial motor neurons appears depleted at 48 hours post fertilization, with increased apoptosis at …
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Neurobehavioral Mechanisms Contributing To Alterations In Food Intake Driven By Caudal Hindbrain Acting Signals
… nucleus tractus solitarius (NTS) in the caudal hindbrain. As such, this dissertation investigates the neurobehavioral mechanisms contributing to alterations in food intake driven by caudal hindbrain acting signals as well as investigations of neurobehavioral individual differences in …
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Mechanism of cell adhesion at the midbrain-hindbrain neural plate in the teleost Danio rerio
… eventually death of the organism. The midbrain-hindbrain boundary (also termed isthmic organizer) is a region of high interest as well in early as also in later development. The isthmic region carries organizer identity by the expression and subsequent release of FGF8. False patterning events of …
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Characterization of Tyrosine Hydroxylase-Positive Neurons Projections from the Paraventricular Nucleus of Hypothalamus to Hindbrain Autonomic Regulatory Centers
Hypothalamus is a key brain region for cardiovascular, behavioral, and metabolic regulation that contains complex type of excitatory or inhibitory neurons. Tyrosine hydroxylase (TH)-positive neurons in the hypothalamus plays important role in cardiometabolic regulation; however, the anatomical …
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Hindbrain Serotonin Neurons Activate 5-HT1A Receptors in the Nucleus Tractus Solitarius (NTS) to Modulate Sympathetic and Ventilatory Recovery Following Hypotensive Hemorrhage
… was to investigate the overall hypothesis that hindbrain serotonergic neurons activate 5-HT1A receptors in the nucleus tractus solitarius (NTS) to modulate sympathetic recovery following hypotensive hemorrhage. Aim one was to determine if caudal hindbrain serotonin neurons are necessary for …
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Multiple roles for Robo1/2 repellent receptors in guiding the facial nucleus and nerve
… the nerve must accurately navigate from the hindbrain to the correct muscles during embryonic development. In the development of the facial nerve, both the cell bodies and the axons undergo specific migration patterns to assemble central neuron patterns and peripheral nerve projections to …
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Mapping the Feeding Circuitry in the Mouse and Human Brain
… control. In particular, the hypothalamus and the hindbrain play key roles in the integration of signals regarding the body’s energy status and coordinating a response to alter changes in food intake. In particular, the hypothalamic leptin-melanocortin pathway is a well characterised signalling …
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Identification and characterisation of novel zebrafish brain development mutants obtained by large-scale forward mutagenesis screening
… in development and function of the midbrain-hindbrain boundary (MHB), an organiser region that patterns the adjacent brain regions of the midbrain and the hindbrain. In the first screen, I could identify 10 specific mutants based on morphology and the analysis of the expression patterns of …
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The formation and function of the brain ventricular system
… embryonic zebrafish. We found that the midbrain-hindbrain boundary acts as a barrier preventing CSF movement between the midbrain and hindbrain, while CSF moves freely between the midbrain and forebrain. Additionally, the heartbeat contributes to CSF movement increasing mixing between the …
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The role of pou2/spiel-ohne-grenzen (spg) in brain and endoderm development of the zebrafish, Danio rerio
… part of the embryonic brain called midbrain-hindbrain boundary (MHB), a region that acts as an organizer for the adjacent brain regions, is established in vertebrates. spiel-ohne-grenzen (spg) is one mutant which interferes with MHB development. Here, I addressed the role of pou2 in brain …
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Development of a Mouse Model of NY99 West Nile Virus-Induced Neurological Changes
… though both were most commonly found in the hindbrain. WNV-infected mice also showed significant changes in the levels of pro-inflammatory cytokines in the cortex and hindbrain, indicating persistent changes in these regions. Microgliosis and viral RNA of certain brain regions correlated with …
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Structural And Chemical Organization Of The Rat Interpeduncular Nucleus
… and several raphe and tegmental centres of the hindbrain. Neurons of the IPN are in receipt of descending habenular projections which provide putative excitatory inputs, as well as intrinsic, putative inhibitory inputs. The integration of habenular inputs with those arising from intrinsic …
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Analysis of HOXA5 expression and function in development of the central nervous system
… a complex HOXA5 expression pattern in the caudal hindbrain. In this structure, we show that HOXA5 expression is confined to the caudal region of the developing inferior olivary nucleus (ION) and dorsal lamella of the dorsal accessory olive (DAO) subnucleus. Furthermore, the ION can be transiently …
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Identification of central circuitry components mediating anorexigenic properties of oxytocin
… the OT receptor in the forebrain versus the hindbrain (via lateral (LV) and fourth ventricular (4V) OT injections, respectively). I established effective doses of BT and LV / 4V OT. Then, I determined doses of LV and 4V OT that reduce hyperphagia produced by BT in sated and deprived rats. …
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In Vitro, In Vivo, and In Silico Studies of Reticulospinal Circuits and Generalized Arousal
… a small group of large-bodied neurons in the hindbrain reticular formation, as a potential neuronal substrate for GA. These neurons are responsive to a wide range of sensory modalities and have diverse projections that target both forebrain areas and motor effectors directly within the spinal …
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Role of the paired-like gene Pitx1 in Xenopus head development.
… is complex and with the exception of the hindbrain region, it is unlike trunk development in as much as it does not involve discrete segmentation. Recent evidence suggests that the paired-like family of genes play a role in regulating anterior development. To further understand the role …
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Stress-Related Effects of Phoenixin on Nucleus of the Solitary Tract Neurons
… a critical autonomic integrating center in the hindbrain, is one of the many areas with dense expression of both PNX and its receptor, GPR173. Using both extracellular and whole-cell current clamp recording techniques in a coronal NTS slice preparation, this study characterized the effects of …
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Evidence for effects of phoenixin on neurons of the paraventricular nucleus
… to the pituitary gland, median eminence and hindbrain, the PVN plays a role in stress response and other autonomic functions. Recent findings have indicated that both phoenixin (PNX), a peptide involved in such responses, and its receptor, GPR173, are expressed throughout the PVN. PNX is …
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