Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"high-throughput drug screen"”.
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… evade cell death. A better understanding of how drugs that perturb autophagy affect cancer cell signaling is of critical importance toimprove the cancer treatment arsenal.</p> <p>In order to gain insights in the relationship between autophagy and drug treatments, we conducted a high-throughput …
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In vivo identification of drug therapeutics for nemaline myopathy
… study employs the DiscoveryProbeTM FDA-approved drug library to perform a small molecule high-throughput drug screen as a strategy for developing therapies for Nemaline Myopathy (NM). Nemaline myopathy is a rare congenital neuromuscular disorder characterized by muscle weakness and the …
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A pathways-based approach identifying determinants of drug resistance in oesophageal adenocarcinoma
… poor at approximately 15%. The development of drug-resistance limits the effectiveness of current chemotherapies, with less than 20% of patients experiencing complete pathological response, so the discovery of underlying resistance mechanisms and novel agents to target these pathways is …
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Integration of Biomedical Imaging and Translational Approaches For Management of Head and Neck Cancer
… and image acquisition techniques, we can achieve high geometric accuracy. These images can then be used to monitor the shrinkage of tumors during RT and optimize the clinical target volumes accordingly. Our results also showed that this MR-guided dose adaptation technique has a dosimetric …