Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"high-resolution respirometry"”.
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Functional responses of cardiac and skeletal muscle mitochondria to short-term obesity: are all obesities the same?
… control (WT) C57-BL6J mice prior to sacrifice. High-resolution respirometry was used to examine mitochondrial function in permeabilized solei muscle fibers and isolated cardiac and skeletal muscle mitochondria obtained from all study groups. Body mass of obese animals was 30 and 50% greater than …
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Novel drug and exercise therapies to restore metabolic function in children with severe burns
… to quantify muscle protein turnover and high-resolution respirometry (HRR) to assay muscle mitochondrial function. Additionally, we were able to use these methods to test the efficacy of a combined pharmacological treatment of a testosterone analog and -blockade in severely burned …
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Microbiome-Brain interactions in Parkinson’s neurodegeneration: The effect of microbiota modulation in a PINK1 mutant Drosophila melanogaster model of Parkinson’s disease
… Mitochondrial respiration was measured using high-resolution respirometry and mitochondrial stress markers were evaluated at mRNA and protein levels, showing changes in the control W1118, versus PINK1B9 mutants, following the bacteria feed. Respiration increased in the control W1118 treated …
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Comparative analysis of the role of redox active molecules on bioenergetically active membranes
… and cell death. The effects that vanadium has is highly dependent on the speciation and state that they exist in. this can impact the system that is being affected and the outcome. Species such as decavanadate have a unique and profound biological effect. Changing of the species, oxidation state …
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Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells
… healthy individuals in a wide age-span using high-resolution respirometry. We concluded that freshly isolated platelets, intact or permeabilised, were well suited for studying human mitochondria ex vivo. With different titration protocols, detailed information of the cellular respiratory …
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The Role of Mouse Placental Endocrine Function on Offspring Metabolic Health
… the effect of Jz-Igf2UE on adipose tissue respirometry, and on the gonadal adipose transcriptome. The impact of Jz-Igf2UE on offspring metabolic health was evaluated via insulin tolerance tests, metabolic cage assessments and measuring lean mass and adiposity at multiple timepoints. Insulin …
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Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, <i>Ictidomys tridecemlineatus</i>.
Brown adipose tissue (BAT) is the major thermogenic tissue in small eutherian mammals. In hibernators, seasonal modifications of BAT are well documented but little is known about its functional regulation during hibernation. BAT metabolism is activated by sympathetic stimulation, so I hypothesized …
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The effect of beta-oxidation or TCA cycle inhibition on mitochondrial function and the sensitivity of high resolution respiratory detection
… may be a more effective assessment technique. High resolution respirometry (HRR) is a recently developed technique that accounts for substrate oxidation, electron transfer via the ETS and oxidative phosphorylation. It measures the rate of oxygen consumption or flux at different respiratory …
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Formazione di proteine canale: dal mitocondrio a SARS-CoV-2. Caratterizzazione funzionale e strutturale attraverso l'uso di tecniche respirometriche e di dinamica molecolare
Le proteine sono macromolecole formate anche da migliaia di unità di amminoacidi unite fra lor per mezzo di legami peptidici, in modo da formare catene variamente ripiegate la cui struttura tridimensionale è in stretta relazione con la funzione biologica svolta; in funzione della loro …