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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"high-intensity focused ultrasound (HIFU)"”.
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Dynamic In-Vitro Assessment of Microbubble-Mediated Dual-Frequency High Intensity Focused Ultrasound (HIFU) Induced Thrombolysis.
North Carolina State University Theses Mechanical and Aerospace Engineering.
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Development of positioning devices for MRI-guided high intensity focused ultrasound (HIFU) for abdominal, thyroid and brain, tumours
High intensity focused ultrasound (HIFU) is a promising technology for a variety of therapeutic applications. This concept initiated in 1942 by Lynn Zwemer [1]. HIFU has long been known as a minimal invasive or non-invasive procedure that destroys tissue through ablation. However, it is only in …
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Experimental Study of Advanced Cryopreservation Strategies for the Cardiovascular System: Superiority of Vitrification over Standard slow Freezing in Murine Vessels and Efficacy of Ultrafast Rewarming by High-Intensity focused Ultrasound (HIFU) in Cardiac Recovery from Deep Hypothermia (-6ºC)
… limited, and cardiovascular grafts are highly susceptible to immune rejection. Currently, cold storage at 0–4 ºC is the gold standard for sample preservation, yet it maintains viability for only a few hours in hearts and a few days in vessels. Beyond this period, ischemic and structural …
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Optimized pulsing of high-intensity focused ultrasound for enhanced therapeutic window
High intensity focused ultrasound (HIFU) provides a unique modality to perform non-invasive surgeries. The thermal ablation technique relies on focusing the non-ionizing acoustic wave within soft tissues to produce a small lesion. HIFU operations are typically attempted by continuous-wave (CW) …
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PHOTOREFRACTIVE CRYSTAL-BASED ACOUSTO-OPTIC IMAGING IN THE NEAR-INFRARED AND ITS APPLICATIONS
… (AOI) is a dual-wave modality that combines ultrasound with diffusive light to measure and/or image the optical properties of optically diffusive media, including biological tissues such as breast and brain. The light passing through a focused ultrasound beam undergoes a phase modulation at …
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Dynamics of smart materials in high intensity focused ultrasound field
… dissertation addresses this requirement by using high intensity focused ultrasound (HIFU) as the external trigger. HIFU has a unique capability of maintaining both spatial and temporal control and propagating over long distances with reduced losses, to achieve the desired response of the smart …
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Cavitation monitoring and spatial mapping for pulsed high-intensity focused ultrasound enhanced drug delivery
High intensity focused ultrasound (HIFU) is an emerging non-invasive ablation modality, in which high amplitude ultrasound waves are focused inside the human body to thermally ablate or mechanically disrupt the tissue at the focus. Ultrasound-enhanced drug delivery is an active and promising area …
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Novel Plasmonic Nanostructures for Applications in Sensing, Imaging, and Controlled Release
… and drug delivery. The first part of this work focused on the development of novel dimeric nanostructures of Ag for surface-enhanced Raman scattering: SERS) applications. In this section, I successfully demonstrated the synthesis of well-defined Ag dimers consisting of nanospheres with a broad …
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Passive monitoring of high-intensity focused ultrasound
High intensity focused ultrasound (HIFU) can provide a means of noninvasive ablation or hyperthermia of tissues such as tumors. Real-time monitoring of the progression of the field distribution of the HIFU transducer during treatment is important for localizing the intersection of the beam with the …
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Multi-functional Holographic Acoustic Lenses for Modulating Low- to High-Intensity Focused Ultrasound
Focused ultrasound (FUS) is an emerging technology, and it plays an essential role in clinical and contactless acoustic energy transfer applications. These applications have critical criteria for the acoustic pressure level, the creation of complex pressure patterns, spatial management of the …
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Propagation of High Intensity Focused Ultrasound through a Patient-specific Ribcage Model
A method of 3D modelling of high intensity focused ultrasound (HIFU) treatment through ribcage using patient data is described. This is further tested experimentally to derive at various parameters which could be indirectly useful in defining amount of energy and alteration needed in treatment …
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The Potential for Ultrasonic Image-Guided Therapy Using a Diagnostic System
<p>Ultrasound can be used for a variety of therapeutic purposes. High-intensity focused ultrasound (HIFU) has progressed over the past decade to become a viable therapeutic method and is valuable as a non-invasive alternative to many surgical procedures. Ultrasonic thermal therapies can also be …
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Fast finite element methods for focused ultrasound applications
… time-domain, fast finite element solver for focused ultrasound (FUS) applications. FUS is a rapidly evolving medical technology used for tissue heating, ablation, and neuromodulation. In recent years, interest in FUS has grown significantly, especially for the treatment of cancers and brain …
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Investigation of Microbubble-enhanced Mild Hyperthermia with Focused Ultrasound for Drug Delivery Enhancement
… However, due to the tumor’s low drug uptake, high doses of these drugs are needed for effective treatment, which can result in adverse side effects. Research has shown that elevating the temperature of the tumor by 5-10 ℃, defined as mild hyperthermia, results in increased drug uptake of the …
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Design and synthesis of mechanoresponsive materials and multivalent polymer-peptide conjugates
… naphthopyran mechanophore. Further, this study highlighted the structure-reactivity relationships which govern naphthopyran mechanochromism. The third chapter of this thesis details the remote generation of light using high-intensity focused ultrasound (HIFU) as a remote force trigger for a …
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Size Effect in Polymeric Materials: the Origins and the Multi-physics Responses in Ultrasound Fields
… PS in nanofibers, their ductility becomes orders higher than their bulk state. In recent years a number of diverse applications, such as scaffolds in tissue engineering, drug delivery devices, as well as soft robotics, are designed by utilizing the unique properties of polymers at nanoscale. …
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Treatment of brain cancer and ischaemic stroke utilising High Intensity Focus Ultrasound (HIFU) guide with MRI
In this thesis high intensity focused ultrasound (HIFU) is utilized for cancer treatment (thermal mode) and treatment of ischaemic stroke (mechanical mode). These two applications were investigated in vitro and in vivo models. MRI was utilized to monitor the lesions created by HIFU either in …
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Shear-wave imaging guidance for high-intensity focused ultrasound therapy
High-intensity focused ultrasound (HIFU) has attracted many research interests during the last three decades (since 1980s) for the precision of this treatment in the field of medical oncology and brain surgery. Even though the precision of HIFU application/exposure is particularly high, the overall …
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Quantitative ultrasound assessment of thermal therapy in liver
Quantitative ultrasound (QUS) is a promising technique for non-invasive tissue characterization. In this work, the potential of QUS to assess thermal therapy in liver tissue was examined. Specifically, the QUS parameters of attenuation slope, effective scatterer size (ESD), effective acoustic …
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Fast estimation model of pressure-temperature response for planning focused ultrasound surgery
High Intensity Focused Ultrasound (HIFU) is becoming a widely accepted modality for extracorporeal non-invasive hyperthermia and surgical procedures. Since ultrasonic transducers need to operate in various challenging body locations, the arrangement of their array elements can be optimized to …
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