Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"high-grade serous"”.
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Augmented Radiology in High Grade Serous Ovarian Carcinoma
… the patient’s own diagnostic journey. The study highlights issues that patients feel should be considered when developing tools which contribute to their care, and makes recommendations on how to pursue patient-focused AI development. With the successful validation of its performance in Chapter …
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Roles of PKR in High Grade Serous Ovarian Cancer
High-grade serous ovarian carcinoma (HGSC) is characterized by dissemination within the peritoneal cavity, a process that critically depends on dynamic regulation of cell adhesion, migration, and invasion rather than primary tumor growth. Protein kinase R (PKR; EIF2AK2) is classically described as …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
<p>High Grade Serous Ovarian Cancer (HGSOC) can be classified by gene copy number signatures into 7 subtypes that have differing prognoses and treatment sensitivities and that show differences in the activities of various signalling pathways. An ongoing clinical study has demonstrated the …
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Improving earlier non-invasive diagnosis of high-grade serous ovarian cancer
… circulating tumour DNA (ctDNA) biomarker for high grade serous ovarian cancer (HGSOC), was to investigate low-cost high-throughput next generation sequencing assays in plasma samples collected from women with newly diagnosed OC. The secondary aim was to apply these methods to other …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… significance of immune cell abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave imprints of copy-number …
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Combination Chemotherapy and In vivo Modeling of BRCA-deficient, High-grade Serous Ovarian Cancer
… silencing. The importance of BRCA-deficiency is highlighted in its association with increased platinum sensitivity. Novel therapeutics such as PARP inhibitors have also been developed by exploiting the synthetic lethal phenotype of BRCA inactivation and PARP inhibition. However over 80% of …
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Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation
High-grade serous ovarian cancer (HGSOC) represents the largest and most lethal subtype of ovarian cancers. Chemotherapy is effective at depleting these tumours, sometimes eliminating all visible disease, however the tumour invariably regrows from surviving tumour cells. Improving treatment depends …
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Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
… the tissue architecture that underlies them in high grade serous ovarian cancer (HGSOC). The quantitative distribution of three key immune infiltrates was initially assessed in the SEARCH cohort (n=332); CD8+ cytotoxic T-cells, CD45RO+ memory T-cells and CD68+ macrophages. The stromal …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… Prior studies showed that BRCA-deficient high grade serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis was performed …
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Fully Automated Segmentation of High Grade Serous Ovarian Cancer on Computed Tomography Images using Deep Learning
… be used for the fully automated segmentation of high grade serous ovarian cancer. The recent rise of deep learning has pushed the limits of what algorithms can achieve in fields of image analysis, such as the task of segmentation. The field of medical image segmentation has fundamentally changed, …
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Unravelling the Spatial and Temporal Heterogeneity of High-Grade Serous Ovarian Cancer Using Imaging-Based Biomarkers
High-Grade Serous Ovarian Cancer (HGSOC) is the most prevalent and lethal subtype of ovarian cancer, characterised by significant spatial and temporal heterogeneity, which has been linked to poor survival outcomes. In this challenging landscape, the quest to characterise heterogeneity through …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
Ovarian high-grade serous carcinomas (HGSC) are the most common and fatal histological subtype of ovarian cancer, characterised by late stage diagnosis and high mortality rates. Unfortunately, the majority of patients (> 85%) will develop fatal chemoresistant disease despite multiple lines of …
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
… by vague symptoms, late diagnosis and a high level of metastasis. While most patients initially respond well to the current standard of treatment – tumour debulking surgery and platinum/taxane combination chemotherapy – patients frequently succumb to recurrent disease which is often …
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ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS
High-grade serous ovarian cancer (HGSOC) is a highly heterogeneous and aggressive malignancy characterized by marked inter-/intra-tumor variability and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
<p> <p>Background: High grade serous carcinoma whether ovarian, tubal or primary peritoneal, continues to be the most lethal gynecologic malignancy in the USA. Although combination chemotherapy and aggressive surgical resection has improved survival in the past decade the majority of patients still …
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The development of a blood-based test of DNA methylation for the earlier detection of high-grade serous tubo-ovarian cancer
Background High grade serous carcinoma (HGSC) is the most common and most aggressive subtype of epithelial ovarian cancer (OC). The majority of patients present in the advanced stage with poor prognosis. If diagnosed in the earliest stage (stage I) survival is greatly improved; however, there is …
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Modeling Pathophysiology of Human Fallopian Tube Using Microfluidic Organ-on-Chip Technology
Ovarian cancer is a deadly disease, and most high-grade serous ovarian carcinomas originate from the fallopian tube epithelium. Understanding the early events of ovarian cancer tumorigenesis in the fallopian tube is crucial for the development of future detection and intervention strategies. This …
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Characterisation of the Tumour Microenvironment in Ovarian Cancer
… crucial aim for the success of cancer therapies. High-grade serous ovarian cancer provides an excellent opportunity to systematically study the tumour microenvironment due to its clinical presentation of advanced disseminated disease and debulking surgery being standard of care. This thesis first …
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Modeling Epithelial Ovarian Cancer In The Mouse
… in the most common form of sporadic EOC, high grade serous adenocarcinoma. Thus, we have initiated development of several mouse models of EOC based on alterations of these genes in the presumed EOC tissue of origin, the ovarian surface e pithelium (OSE). By using a new approach of in situ …
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