Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 459 for “"high-fat"”.
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Smoking and High-Fat Diet: Risk Factors Regulating Emphysema Formation
… secondary to cigarette smoke exposure or to a high-fat diet. The study reported in chapter two explores the effect of cigarette smoke on the pulmonary inflammation and proteolytic response leading to the development of emphysema in guinea pigs. For the first time, we demonstrated that …
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The Effect of Ischemia and High-Fat Diet on Pericyte Fate
… of my thesis was to assess the effects of high fat (HF) diet and ischemia on skeletal muscle pericytes. Pericytes are mural cells on the abluminal surface of capillaries that contribute to capillary stabilization and the regulation of angiogenesis, but their roles in the events that occur …
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The Maladaptive Response of Adipose Tissue to High Fat Diet Feeding
The ability of organisms, from yeast to humans, to safely store energy as dense hydrophobic carbon chains secured away in lipid droplets represents an incredible evolutionary advantage. The further use of adipocytes as a professional lipid storage cells emphasizes the importance and benefit of safe …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… in mice as a loss of interest in consuming a highly palatable sucrose or saccharin solution. Here we show that obese mice fed a high-fat diet (HFD), fail to exhibit an interest in saccharin (27% vs 74%) compared to mice fed a low-fat diet (LFD) (p < 0.007). When HFD mice undergo a fasting …
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Feeding Value of High Starch and High Fat Rations for Dairy Calves
… to evaluate growth performance when fed control, high starch, and high fat pelleted diets separately or with a supplemental concentrate mix offered the first 6 wk. High starch and high fat diets were formulated to .contain more digestible energy than the control diet. Calves received milk the …
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High Fat Diet Effects on Erythrophagocytosis and MCP-1 Levels in Mice
… atherosclerotic plaques. Although exposure to a high fat diet (HFD) has been shown to alter RBC membrane properties, how this physiological change may affect RBC chemokine binding and macrophage interaction is less known.</p><p>Objective: To determine the effects of a high fat diet on murine RBC …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… diet (RD) and additionally WT mice were fed a high-fat diet (HFD). All mouse groups were challenged with intraperitoneal injections of either saline or LPS (5 mg/kg; one or five times on a monthly basis). Significant genotype and diet effects were observed in behavioral, metabolic and …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… diet (RD) and additionally WT mice were fed a high-fat diet (HFD). All mouse groups were challenged with intraperitoneal injections of either saline or LPS (5 mg/kg; one or five times on a monthly basis). Significant genotype and diet effects were observed in behavioral, metabolic and …
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Do Probiotics Protect Against the Deleterious Effects of a High-Fat Diet?
High-fat diets and obesity have been linked to unfavorable changes in gut bacteria and increased leakage of bacterially-derived lipopolysaccharide (endotoxin) from the intestinal tract into circulation, which is associated with low-grade inflammation, metabolic dysregulation and degradation of …
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Skeletal muscle metabolic adaptations in response to an acute high fat diet
… disease state, protein, carbohydrate and fat have varying capacities to be oxidized and balanced. Further, when analyzing the oxidation of carbohydrate and fat in the skeletal muscle specifically, carbohydrate balance happens quite rapidly, while fat balance does not. The ability of …
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Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
Skeletal muscle is highly involved in macronutrient metabolism. To maintain proper energy metabolism and physiology, skeletal muscle must adapt to nutrient supply. Thus, diet macronutrient composition is an important modulator of skeletal muscle metabolism. Evidence from rodent and human models …
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Maternal High Fat Feeding: Impact of Female Offspring Body Composition and Bone Health
High fat diet (HFD) consumption in rodents alters body composition and weakens bones. Whether female offspring of mothers consuming a HFD are similarly affected at weaning and early adulthood is unclear. This research determined whether maternal HFD contributes to long-lasting alterations in body …
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SEC16B modulates high fat diet induced obesity in female but not male mice
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Skeletal Muscle Acetylation in Response to an Acute and Chronic High-Fat Diet
… apoptosis, and more. Metabolic proteins are highly susceptible to acetylation with almost all showing the capacity to be acetylated. Our research, using an obese mouse model fed a chronic high fat diet and a lean control mouse model fed a standard chow diet, showed numerous differences in the …
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Insulin Signaling & Glucose Metabolism in Glycolytic & Oxidative Muscle of High Fat Fed & Endurance Trained
This study examines the effects of a chronic high-fat diet (HFD) and chronic endurance exercise (CEE) upon muscles of varying oxidative (Ox) and glycolytic capacities. We report that chronic HFD leads to significantly high levels of blood glucose and insulin concentrations. These high …
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The effects of a low-carbohydrate, high-fat diet on type 2 diabetic patients
… the effectiveness of a low carbohydrate high fat diet (LCHFD) on Type 2 diabetic patients. Secondly, to see what the effects of a concurrent physical activity programme with an LCHFD will have on Type 2 diabetic patients. Lastly, this study aimed to determine the effects on cholesterol …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… a hindered ability to properly transition from fat oxidation while in a fasted state to carbohydrate oxidation once fed, leading to a buildup of mitochondrial metabolites such as acylcarnitines. Carnitine, essential for fatty acyl-CoA transport through the inner and outer mitochondrial …
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The Effects of a 5-Day High-Fat Diet on Skeletal Muscle O-GlcNAcylation
Continual intake of high-fat foods, coupled with limited physical activity, can lead to metabolic inflexibility. Eventually, this may lead to significant health issues such as obesity, insulin resistance, cardiovascular disease, and other chronic diseases. Metabolic flexibility of human skeletal …
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Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training
… to contribute toward insulin resistance. High-fat diets reduce human skeletal muscle insulin sensitivity and mitochondrial function. Conversely, endurance training increases insulin sensitivity and enhances mitochondrial performance. Recent evidence in mice has found that central …
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