Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"high-content analysis"”.
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Rapid 3D characterization of whole vertebrate brain at cellular resolution
… Zebrafish, a unique model organism for high-throughput applications, have become increasingly popular for neuroscience research because of its small size and optical transparency of its brain. However, current phenotypic analysis of zebrafish relies heavily on qualitative methods such as …
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Chlorpyrifos and chlorpyrifos oxon induce neurite retraction and cytoskeletal disruption in mouse N2a cells and human neural progenitor stem cells
… N2a cells, as indicated by morphometric analysis of carboxyfluorescein succinimidyl ester-labelled cells. Retraction of neurites was observed within 2 h of exposure by live cell imaging. Neurofilament disruption was detected in treated cells, by indirect immunofluorescence with …
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Role of long non-coding RNA in atherosclerosis
… 2 myocardial infarction, mortality rates remain high; up to 15% and 25%, respectively. Although risk stratification tools like GRACE 2.0 score can robustly predict outcome in these patients, new therapies targeting the unstable plaque are still needed to address this global epidemic. Long …
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Effects of GATA4-targeted compounds in hypertrophic models of hypoplastic left heart syndrome cardiomyocytes
Synnynnäiset sydänviat kehittyvät sydämen kehityksen aikana ja määritellään syntymähetkellä läsnä oleviksi sydämen rakenteellisiksi poikkeavuuksiksi, joista vasemman sydänpuoliskon vajaakehittyneisyysoireyhtymä (HLHS) edustaa harvinaista mutta hengenvaarallista alatyyppiä. HLHS:lle on ominaista …
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Discovery of new biomarkers of mild cognitive impairment and Alzheimer's disease risk in buccal cells using laser scanning cytometry
… imaging and immunohistochemistry with high-content, multi-color fluorescence analysis, and can be used to identify specific cells in a heterogeneous population as well as scoring unique molecular events within them. This study aimed at investigating buccal cell types (buccal cell …
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Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling
Man-made chemicals are a part of everyday life and may mimic hormonal signalling in wildlife and humans. These exogenous mixtures or substances are called endocrine disrupting chemicals and may lead to adverse health effects in those exposed. Persistent organic pollutants (POPs) are a class of …
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Investigating the endocrine disrupting potential and cytotoxic effects of packaging leachates and plasticisers
… often have hormonal activity, therefore highlighting the potential for endocrine disrupting leachates to be present. This thesis assessed novel naturally produced bio-based polymers that are currently being explored as a potentially safer alternative to current synthetic plastics using in …