Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"high resolution mass spectrometry"”.
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Using high resolution mass spectrometry to profile impurities in drugs from different sources
… prior to crystallisation was investigated using high resolution mass spectrometry in combination with chemometric modelling of the data. Several impurities of lipoic acid were characterised by using MSn and the success of the purification process in removing impurities was verified. In chapter 4 …
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Studies of new natural products and their biosynthesis spearheaded by high-resolution mass spectrometry
… unit into the growing chain can be measured as a mass shift to the biosynthetic proteins by mass spectrometry. Specifically, Fourier-transform mass spectrometry (FTMS) (and an associated suite of custom MS tools) is a high-resolution analytical technique well suited to the study of NRPS and PKS …
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Investigating the Molecular Composition of Rainwater and Secondary Organic Aerosol using Ultra-High Resolution Mass Spectrometry
… were observed in the rainwater. HYSPLIT air mass backward trajectories revealed that both air mass origin and seasonality had strong influences on the sample composition. Samples collected during the summer and samples influenced by the Sahara desert contained the most compounds due to …
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A study of the metabolism and metabolomics of polyphenols using isolated rat hepatocytes and liquid chromatography-high resolution mass spectrometry
… by liquid chromatography in combination with high resolution mass spectrometry. This was followed by extraction of the data with Sieve software and identification of the metabolites based on their elemental composition. MS2 and MS3 experiments were used to further characterise the metabolites. …
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High Resolution Mass Spectrometry (HRMS) Based Investigation of Small Molecule, Bioactive Secondary Metabolites as Probes in the Examination of Bacterial Resistance and Virulence
… work seeks to illustrate applications in which mass spectrometric techniques may be applied to the investigation of novel, small molecule chemotherapeutics for the treatment of bacterial infections. Chapter 1 contains an introduction to mass spectrometry, as well as an overview of relevant …
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Metabolomic and metabolomic flux studies of the effects of sphingosine kinase inhibitors on prostate cancer cells using high-resolution mass spectrometry as an analytical technique
… and sphinganine-1-phosphate metabolism. Several highly potent selective SK1 and SK2 inhibitors (PLR24, ST55 and ST81) were also used in LNCaP-AIcells and LNCaP-SK1b cells, and shown to disrupt the sphingolipid rheostat and modulate phospholipid turnover. The major conclusion of this thesis is …
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Isolation and physiochemical characterization of dissolved organic matter across limnic and oceanic systems
… well as the Pony Lake samples were analyzed via high-resolution mass spectrometry and compared to international standards from the International Humic Substance Society. Two prepublished works are also included in this dissertation. The first creates an acid-base titration methodology utilizing …
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Microbial adaptation to dissolved organic matter in freshwater ecosystems
… full length 16S amplicon sequencing and ultra-high resolution mass spectrometry, I tracked how the six-species community changed in composition over a 14-day incubation on each source and characterized how the microbes reworked the DOM. I further correlated changes in species abundances with …
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Abiotic and Biotic Polymer Degradation to Inform Sustainable Design
… dissolved organic carbon (DOC), which proved highly biodegradable in marine environment. Chemical structural differences were clearly linked to degradation behaviors, emphasizing the utility of the developed workflow for rapidly identifying environmentally relevant degradation mechanisms, …
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PHOTOLYSIS OF1-METHYL-9,10-ANTHRAQUINONE DERIVATIVES AND THEIR POTENTIAL REACTIVITY IN THE PHOTOENOL DIELS-ALDER REACTION
… of the compounds was achieved by NMR, high-resolution Mass Spectrometry, and X-ray crystallography.
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Aspects of the chemistry of 1,4-naphthoquinones. An investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution.
… synthesised. The collision-induced dissociation mass spectra of protonated hydroxyalkylamino-1,4- naphthoquinones showed fragmentation patterns which were dependent on the nature and length of the side chain and the presence and nature of the adjacent group on the 3-position on the …
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Investigating Complex Organic Species on Mineral Surfaces
… layer can be removed and identified by high resolution mass spectrometry. Finally, to facilitate the detailed understanding of complex systems, a model system investigated. Adsorption of stearic acid on the calcite surface in toluene was investigated via depletion isotherms, neutron …
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Hydrophosphination of Vinylcyclopropane & Quinine for Metal Coordination Chemistry
… facilitating catalytic reactions for producing high value chemicals. Consequently, significant interest exists in developing new and efficient synthetic routes for new phosphorus-containing molecules. One key approach is hydrophosphination, where a phosphorus-hydrogen (P-H) bond is added across …
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Microwave-assisted Synthesis of Modified Cyclopentadienyl Iridium and Rhodium Chloro-bridged Dimers
… diffraction (XRD) (supplemented by powder XRD), high-resolution mass spectrometry (HRMS), and elemental analysis. Complexes studied by XRD were analyzed to understand the bond lengths and bond angles throughout each complex. The dimeric complexes synthesized, will facilitate a complete study on …
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Multi-omic Approaches to Investigate the Inflammatory Response in Activated Macrophage Cells
… of tissue homeostasis. It constitutes a highly complex<br/>and tightly regulated sequence of events in which macrophages play a central<br/>role, by eliciting cellular pathways that produce inflammatory mediators to<br/>neutralize and eliminate invading pathogens and repair tissues …
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Establishing a protocol to measure tetrodotoxin (TTX) levels in small bodied newts (genus Lissotriton) in western Europe
… protocols before employing HPLC/UV/Vis spectrometry. While strong candidate peaks for TTX were identified in some samples, the employed approach was not sufficiently sensitive to unambiguously demonstrate its presence. Three of the adult newts collected from England were further tested …
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Mechanism of the hydropyrolysis of Manvers coal
… the products of pyrolysis: gas chromatography - mass spectrometry and high performance liquid chromatography for tars; thermal conductivity gas chromatography and high resolution mass spectrometry for gases; methanol densities, microporosities and diffuse reflectance infra red spectroscopy for …
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Measurement of neuropeptides: From presence to release
… a peptide database for the hippocampus through high resolution mass spectrometry with which to reference microdialysate peptides. The rats were also exposed to various treatments including acute morphine, though the rats were most strongly distinguished by animal and not treatment via principal …
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