Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"high grade serous ovarian carcinoma"”.
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Augmented Radiology in High Grade Serous Ovarian Carcinoma
… topics will be considered in the context of ovarian cancer, a complex, multi-site disease which is frequently diagnosed at late stage, and for which limited improvement in survival outcomes has been made in recent decades. Chapter 3 considers the clinical utility of a newly developed AI-based …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… significance of immune cell abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave imprints of copy-number …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… Prior studies showed that BRCA-deficient high grade serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis was performed …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
<p> <p>Background: High grade serous carcinoma whether ovarian, tubal or primary peritoneal, continues to be the most lethal gynecologic malignancy in the USA. Although combination chemotherapy and aggressive surgical resection has improved survival in the past decade the majority of patients still …
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Investigation of the cancer testis antigen lactate dehydrogenase C as a CD8 T cell target
The infrequency of known T cell targets in high grade serous ovarian carcinoma (HSGC) is a substantial barrier to the development of targeted immunotherapies. Due to their infrequency, antigen discovery is a crucial component of immunotherapeutic design. In our cohort of HGSC cases, the cancer …
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
High grade serous ovarian carcinoma (HGSC) is the most fatal gynecological cancer, due to the aggressive, heterogeneous nature of the tumours. Despite an initially favourable treatment response, patients with HGSC often develop resistance to the first-line platinum-based chemotherapies. In …
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Roles of PKR in High Grade Serous Ovarian Cancer
High-grade serous ovarian carcinoma (HGSC) is characterized by dissemination within the peritoneal cavity, a process that critically depends on dynamic regulation of cell adhesion, migration, and invasion rather than primary tumor growth. Protein kinase R (PKR; EIF2AK2) is classically described as …
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Role of inherited DNA repair deficiencies in cancer susceptibility and evolution
… mechanisms act on the human genome, maintaining high replication fidelity and genome stability. Deficiencies in these processes result in an accumulation of post-zygotic mutations with characteristic signatures. This genomic instability is associated with the heritability of multiple cancer …
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Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation
… First, Cdk12 loss-of-function mutations populate high-grade serous ovarian carcinoma and castration-resistant prostate tumors raising the possibility that Cdk12 mutational status may predict the effectiveness of chemotherapeutics that target HR-deficient tumors. Second, readily available small …
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
<p>High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. Angiogenesis is a vital function for both wound healing and oxygen homeostasis and is one of the hallmarks of cancer in solid tumors. To …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… of new RBPs that affect chemosensitivity in high-grade serous ovarian carcinoma (HGSOC) we performed a targeted CRISPRi screen in vitro against 579 RBPs to identify those that cause sensitivity or resistance to cisplatin, oxaliplatin, paclitaxel, or olaparib. The screen implicated several …
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Advancing Ovarian Cancer Diagnostics: Discovering Potential Protein Biomarkers in Extracellular Vesicles
High grade serous ovarian carcinoma (HGSOC) accounts for ~70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. The goal of these studies was to uncover novel biomarkers …
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Tumour evolution in ovarian cancer using high-throughput genomics technologies
High-grade serous ovarian carcinoma (HGSOC) is characterised by genomic instability, ubiquitous TP53 loss, widespread disease at diagnosis and the frequent emergence of platinum resistance. This thesis explores the use of high-throughput genomics technologies to understand if resistance could be …
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Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
High grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer and the major cause of gynaecological cancer-related deaths in the Western world. Overall survival for HGSOC patients has not improved over the last two decades, and the progressive evolution of chemotherapy …
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A Review of Women with Epithelial Ovarian Carcinoma in a Middle-Income setting: Groote Schuur Hospital, Cape Town, South Africa: Demographics, Treatment and Outcomes of Patients between 2005 and 2015
… In 2020 there were 313 959 new cases of Ovarian carcinoma worldwide.1 It is one of the most challenging female gynaecological cancers to manage with a poor prognosis for latestage disease and high recurrence rates. Ovarian Carcinoma ranks 8th amongst new cancer cases in women and accounts …
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Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer
<p>Ovarian cancer is the fifth leading cause of cancer death in women between the ages of 35 and 74. With 22 thousand new cases and 15 thousand deaths annually ovarian cancer is among the most deadly cancers with a death to incidence ratio of 68%. With 70% of cases High Grade Serous Ovarian …
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Integrating Bulk and Single-Cell Transcriptomics to Investigate Intratumor Heterogeneity
… is critical for advancing cancer biology, yet high-throughput expression profiles from tumor tissues only represent combined signals from all diverse cellular sources. Bulk deconvolution with single-cell/nucleus (sc/sn) RNA-seq data has emerged as a powerful approach to dissect both cellular …
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Compositional models for mutational signature analysis
… to existing fixed-effects alternatives, and higher specificity than compositional models that do not allow any overdispersion. Similarly, the incorporation of random intercepts in the logistic-normal model for copy number data increases sensitivity with respect to the fixed-effects version. …