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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 274 for “"high fat diet"”.
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Smoking and High-Fat Diet: Risk Factors Regulating Emphysema Formation
… secondary to cigarette smoke exposure or to a high-fat diet. The study reported in chapter two explores the effect of cigarette smoke on the pulmonary inflammation and proteolytic response leading to the development of emphysema in guinea pigs. For the first time, we demonstrated that …
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The Effect of Ischemia and High-Fat Diet on Pericyte Fate
… of my thesis was to assess the effects of high fat (HF) diet and ischemia on skeletal muscle pericytes. Pericytes are mural cells on the abluminal surface of capillaries that contribute to capillary stabilization and the regulation of angiogenesis, but their roles in the events that occur …
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The Maladaptive Response of Adipose Tissue to High Fat Diet Feeding
The ability of organisms, from yeast to humans, to safely store energy as dense hydrophobic carbon chains secured away in lipid droplets represents an incredible evolutionary advantage. The further use of adipocytes as a professional lipid storage cells emphasizes the importance and benefit of safe …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… in mice as a loss of interest in consuming a highly palatable sucrose or saccharin solution. Here we show that obese mice fed a high-fat diet (HFD), fail to exhibit an interest in saccharin (27% vs 74%) compared to mice fed a low-fat diet (LFD) (p < 0.007). When HFD mice undergo a fasting …
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High Fat Diet Effects on Erythrophagocytosis and MCP-1 Levels in Mice
… atherosclerotic plaques. Although exposure to a high fat diet (HFD) has been shown to alter RBC membrane properties, how this physiological change may affect RBC chemokine binding and macrophage interaction is less known.</p><p>Objective: To determine the effects of a high fat diet on murine RBC …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate LPS-induced neurodegeneration. To ascertain the participation of IL-1 beta, three strains of mice were employed: a control [wild type (WT)], a strain lacking the endogenous antagonist of IL-1, namely IL-1 …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… chronic low-grade inflammatory state caused by diet-induced obesity would exacerbate LPS-induced neurodegeneration. To ascertain the participation of IL-1 beta, three strains of mice were employed: a control [wild type (WT)], a strain lacking the endogenous antagonist of IL-1, namely IL-1 …
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Do Probiotics Protect Against the Deleterious Effects of a High-Fat Diet?
High-fat diets and obesity have been linked to unfavorable changes in gut bacteria and increased leakage of bacterially-derived lipopolysaccharide (endotoxin) from the intestinal tract into circulation, which is associated with low-grade inflammation, metabolic dysregulation and degradation of …
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Skeletal muscle metabolic adaptations in response to an acute high fat diet
… Depending on a number of variables, for example, diet, fitness level, or metabolic disease state, protein, carbohydrate and fat have varying capacities to be oxidized and balanced. Further, when analyzing the oxidation of carbohydrate and fat in the skeletal muscle specifically, carbohydrate …
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SEC16B modulates high fat diet induced obesity in female but not male mice
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Skeletal Muscle Acetylation in Response to an Acute and Chronic High-Fat Diet
… rise in obesity worldwide owing to a change in dietary composition, quantity of food consumed- positive energy balance, and a more sedentary life style. Accompanied with obesity is a chronic low grade inflammatory state defined by increased circulating cytokines and an increase in gene …
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The effects of a low-carbohydrate, high-fat diet on type 2 diabetic patients
… the effectiveness of a low carbohydrate high fat diet (LCHFD) on Type 2 diabetic patients. Secondly, to see what the effects of a concurrent physical activity programme with an LCHFD will have on Type 2 diabetic patients. Lastly, this study aimed to determine the effects on cholesterol …
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The Effects of a 5-Day High-Fat Diet on Skeletal Muscle O-GlcNAcylation
Continual intake of high-fat foods, coupled with limited physical activity, can lead to metabolic inflexibility. Eventually, this may lead to significant health issues such as obesity, insulin resistance, cardiovascular disease, and other chronic diseases. Metabolic flexibility of human skeletal …
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Set shifting ability of rats perinatally exposed to bisphenol A and a high fat diet
… brain. Additionally, the traditional American diet is high fat, which also contributes to both physiological, behavioral and inflammation problems. Together, these two factors could exacerbate one another in the brain, which could lead to some cognitive impairment. In order to test this …
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Skeletal Muscle Substrate Metabolism following a High Fat Diet in Sedentary and Endurance Trained Males
… lipotoxicity caused by an impaired regulation of fat uptake and oxidation is postulated to disrupt insulin signaling and lead to skeletal muscle IR. High dietary saturated fat intake results in reduced basal fat oxidation and a resistance to switching to carbohydrate oxidation during …
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Lifestyle factors and nutritional analysis of a low carbohydrate high fat diet in type 2 diabetics
… by uncontrolled hyperglycaemia due to high concentrations of glucose in the bloodstream, which is caused by the failure of muscle cells to respond to insulin. This condition, known as insulin resistance, is where a high concentration of glucose results from pancreatic β-cells working …
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Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated H[subscript]2O[subscript]2 emission from muscle mitochondria, and that …
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The effects of a high fat diet on musculoskeletal health in aged male C57BL/6J mice
… to study these aspects because of current high rates of obesity and the increasing proportion of seniors in North America. This study investigated the effects of a long-term high fat and sucrose diet (HFS) superimposed with aging on bone and muscle structure and function. Male C57BL/6J mice …
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Epigenetic regulation of genes related to lipid metabolism by microrna in mice fed high fat diet
High fat diet impacts lipid metabolism by altering the transportation, oxidation, and storage of fatty acids. Lipoprotein lipase (LPL) plays a critical role in lipid metabolism by catalyzing triglyceride hydrolysis and lipoprotein uptake in multiple tissues. A previous study reported that miR-29b …
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