Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"high dose rate"”.
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Automated Treatment Planning in High Dose-Rate Brachytherapy for Cervical Cancer
… by a boost to the cervix tumor site with High-dose-rate brachytherapy (HDRBT). HDRBT is a procedure that involves the insertion of radioactive sources into the tumorous area to ablate the cancer. Treatment planning for the procedure is typically performed on the day of treatment. The …
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The effect of high dose rate on tissue equivalent proportional counter measurements in mixed neutron-gamma fields
… power plants. In such radiation fields, the dose rate of each component can vary drastically from extremely low to very high. Among these possible combinations of radiation fields with very different dose rates, a mixed field of an intense photon and a weak neutron dose component is the more …
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Application and Development of Algebraic Reconstruction Algorithms for High Dose Rate Brachytherapy Gel Dosimetry with Optical Computed Tomography Readout
… is known as patient specific quality assurance. High dose rate (HDR) brachytherapy treatments have become more complex, but patient specific QA has not been adopted. One reason for this is the lack of inexpensive, simple to use, accurate, and complete dosimeters for brachytherapy. Radiochromic …
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Development and Implementation of A Remote Audit to ol For High Dose Rate (Hdr) 192Ir Brachytherapy Using Optically Stimulated Luminescence Dosimetry
… determine correction factors for linearity with dose, dose rate, and the combined effect of irradiation energy and phantom construction. The uncertainties introduced by source positioning in the phantom and timer resolution limitations were also investigated. It was found that the linearity …
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Pre-clinical evaluation of lethal and sublethal DNA damage in human cell cultures by ultrashort pulse and ultra-high dose rate laser accelerated protons
… brain and heart. Numerous studies have demonstrated the feasibility of using high LET particles in tumor cells; however, the very high installation and operational costs limit the utilization of particle therapy.<br/><br/>The idea of future facilities based on laser-driven ion accelerators has …
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Design of an Ytterbium-169 brachytherapy source for gold nanoparticle-aided radiation therapy
… radiosensitizer for radiation therapy due to the high-atomic-number nature of gold and the increased tumor specificity in nanoparticle form. The degree of radiosensitization is highly dependent on both the local gold nanoparticle concentration in the tumor and the radiation source type. Previous …
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RADIATION-INDUCED CHROMOSOME INSTABILITY AND INTERCELLULAR COMMUNICATION: THE ROLE OF DOSE RATE AND IMPLICATIONS FOR CARCINOGENESIS
The biological risks associated with low dose and low dose rate (LDR) radiation exposures are not yet well characterised. Experimental studies indicate that in addition to biological effects resulting from direct DNA damage, a variety of non-DNA targeted effects (NTE) including radiation-induced …
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Dose intercomparisons between computer planning, in-vivo and phantom measurements for Iridium-192 HDR Brachytherapy
During gynaecological high-dose rate (HDR) intracavitary brachytherapy (ICBT), invivo dosimetry is done to monitor the dose received by the bladder and rectum. This study was aimed at validating the need to do in-vivo dosimetry during ICBT. Thirty patients were recruited to participate in the …
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Electron beam interactive oxide films for nanometer scale lithography
… by rf sputtering have been found to show high resolution lithographic characteristics when exposed under high dose rate conditions in a scanning transmission electron microscope. Holes and lines less than 10 nm in dimensions have been formed in amorphous films of Al$\sb2$O$\sb3$, …
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Proof-of-Concept For Converging Beam Small Animal Irradiator
… perform an in-depth proof-ofconcept</p> <p>for a high dose rate, high precision converging beam small animal irradiation platform.</p> <p>In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for</p> <p>high output and high directionality was designed and …
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Ion dosimetry for radiobiology experiments employing laser-accelerated beams
Cell behaviour in ultra-high dose rate environments, characteristic of laser driven ion acceleration, is a largely unexplored field of research, the understanding of which is crucial to the development of an all-optical delivery of ion beams suitable for cancer treatment. In conducting cell …
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Advanced brachytherapy dosimetric considerations
… was investigated with emphasis on evaluations of dose distributions and shielding considerations for both photon- and neutron-emitting radionuclides. Monte Carlo simulation methods were employed to calculate dose distributions for virtual and commercial brachytherapy sources. Radionuclides studied …
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Braquiterapia de baja tasa de dosis frente a braquiterapia de alta tasa de dosis en una fracción en el tratamiento de cáncer de próstata
… II prospective study of the use of conformal high-dose-rate brachytherapy as monotherapy for the treatment of favorable stage prostate cancer: a feasibility report. Int J Radiat Oncol Biol Phys. 2001; 49: 61-9. 2. Prada PJ, Juan G, Gonzalez Suarez H, Fernandez J, Jiménez I, Amón J, Cepeda …
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Gamma and neutron dose profiles near a Cf-252 brachytherapy source
… them suitable to be used with the conventional high-dose-rate (HDR) remote afterloading systems for interstitial brachytherapy. A recent in-water calibration experiment showed that the measured gamma dose rates near the new source are slightly greater than the neutron dose rates; contradicting …
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Intelligent Automatic Treatment Planning for Radiation Therapy
Radiation therapy (RT) utilizes high-energy radiation to disrupt the DNA of cancer cells, impeding their repair and division, ultimately causing cancer cell death. The goal of RT is to spare radiation dose to healthy cells while maintaining the dose to cancer cells. Modern RT employs advanced …
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Voxel-Level Absorbed Dose Calculations With A Deterministic Grid-Based Boltzmann Solver For Nuclear Medicine and The Clinical Value of Voxel-Level Calculations
<p>Voxel-level absorbed dose (VLAD) is rarely calculated for nuclear medicine (NM) procedures involving unsealed sources or 90Y microspheres (YM). The current standard of practice for absorbed dose calculations in NM utilizes MIRD S-values, which 1) assume a uniform distribution in organs, 2) do …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
… pancreatic cancer (PDAC), the ETC is highly stimulated to generate the copious ATP needed by the tumor to grow. However, extended ETC use increases reactive oxygen species (ROS), and if left unchecked, results in cell death. To evade this, PDAC employs antioxidant strategies, including …
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New Optimization Technique for Radiation Therapy Planning
… goal of radiation therapy is to deliver a lethal dose of radiation to the targeted tumor while minimizing the radiation dose to the surrounding normal tissues and critical organs. Modern cancer therapy has benefited enormously from computer controlled treatment devices with increased precision and …
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Experimental measurements and Monte Carlo simulations of a transport beamline for laser-driven proton beams
… and, consequently, to a larger availability of high-energy ion beams around the world. Up to now, optically accelerated ion beams are characterised by extreme features, not suitable for many applications and of course also for the hadrontherapy applications, that are the most demanding in terms …
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Facilitating the Clinical Translation of Flash Radiotherapy Through Dosimetry Development and Beam Parameter Optimization
… complications<sup>1</sup>. Recently, ultra-high dose-rate (UHDR) RT (mean dose rates ≥40 Gy/s for a total duration of ≤200 ms) has been reported to selectively spare normal tissues and organs while maintaining an isoeffective tumoricidal effect compared to conventional (CONV) dose rate RT in …
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