Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"high affinity IgE receptor"”.
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Polymorphisms of High-affinity IgE Receptor Genes in Patients with Aspirin-Intolerant Chronic Urticaria
… is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU). Atopy was reported a risk factor for a patient with AICU and approximately 40% of patients with chronic urticaria have autoimmune urticaria. The …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
In addition to high-affinity IgE receptor (FcεRI), a subtype of mast cells (MCs) found primarily in human skin, expresses a G protein-coupled receptor (GPCR) known as MRGPRX2 (mouse counterpart MrgprB2). Following agonist stimulation, GPCRs couple to G proteins to cause cellular activation but most …
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Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E
Cross-linking of IgE by allergen triggers many cellular processes that drive allergic disease. While the role of IgE in mediating allergic responses is best described on basophils and mast cells, expression of the high-affinity IgE receptor on other innate immune cells, including monocytes, …
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The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function
… external" environment." MCs" expresses"several"receptors"on"their"surface"such"as"the"high"affinity"IgE"receptor" (Fc!RI)"and"G"ProteinECoupled"Receptors"(GPCRs)."MRGPRX2"is"a"GPCR,"which" consists"of"seven"transmembrane"domains"and"is"expressed"exclusively"in"MCs" but" no" other" immune" …
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MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction
In addition to high affinity IgE receptor, human mast cells (MCs) express a newly identified receptor known as Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse ortholog MrgprB2). This receptor is predominantly expressed on only one subtype of MCs and it can be activated by a diverse group …
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Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells
… presence of TGFβl were functionally impaired, as IgE-mediated cytokine secretion was greatly reduced. The changes in granule formation and surface antigen expression were long-standing, as they were not reversed by transfer to W/WV mice. The TGF-β1 dependent transcriptional regulation of bone …