Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"hexokinase"”.
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Studies on Hexokinase Isoenzymes in Chicken Liver
Made available in DSpace on 2015-05-12T22:36:25Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7114840.PDF: 5271011 bytes, checksum: e15cdf8da8fd7beb4113c239cbca9014 (MD5) Previous issue date: 1970
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Study of the differential compartmentation and functions of hexokinase isoforms and implications for cancer metabolism
… to this highly glycolytic phenotype is hexokinase 2 isoform (HK2), which is significantly overexpressed in many tumors but not in normal adult tissue. Several small molecule inhibitors targeting HK have exhibited promising anticancer activity. However, these small molecule inhibitors …
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The effect of diabetes and insulin on the turnover of hexokinase II in the skeletal muscle
… for the reported decrease in the measurable hexokinase II activity in the skeletal muscle of the streptozotocin-diabetic rat. An ELISA procedure was developed to determine the amount of hexokinase II protein in the skeletal muscle extracts, and immunoprecipitation was utilized to determine …
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A comparison of some potential indicators of desiccation-tolerance in 2 Poikilochlorophyllous Xerophyta species and Homiochlorophyllous Craterostigma wilmsii
… and hexose sugar flux, an increase in hexokinase activity, and accumulation of LEA-like proteins, were investigated and compared during dehydration between two moncotyledonous poikilochlorophyllous resurrection angiosperm species; Xerophyta schlecterii and Xerophyta humilis, and a …
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A comparison of leaf sucrose accumulation and regulation between plants of C.Plantagineum dried in the light and dark
… light and dark treatments were examined, namely: hexokinase, acid invertase and aldolase. The amount of glucose, fructose and sucrose during the dehydration process in both light and dark treatments were also examined. Results obtained show a significant decrease in sucrose (9.8-fold decrease) …
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Metabolic basis for the preferential utilization of disaccharide, by the cellulose-decomposing bacterium, cellvibrio gilvus (nov. sp.)
… from cellobiose. Thus, hypotheses that adaptive hexokinase, hexokinase deficiency or impermeability to glucose could explain the preference were dispelled. Oxygen assimilation ratios of equivalent amounts of glucose, cellobiose and a mixture of these were 100:110:140. Alternate metabolic pathways …
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Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach
… of these disease targets, which include T. cruzi hexokinase, farnesyl diphosphate synthase, undecaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase.
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Untersuchung sub-mitochondrialer Proteinverteilungen in unbehandelten und apoptotischen humanen Zellen mittels STED-Mikroskopie
… hVDAC und seinem putativen Interaktionspartner Hexokinase-I isoform-spezifisch ist. Da zudem ein Anteil der Hexokinase-I mit keiner der drei hVDAC-Isoformen kolokalisiert, deutet dies auf ein komplexeres Zusammenspiel dieser Proteine hin als zuvor angenommen. (2) Apoptose, eine Form des …
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Flavonol kaempferol in the regulation of glucose homeostasis in diabetes
… of diabetic mice. Kaempferol treatment restored hexokinase activity in the liver and skeletal muscle and reduced pyruvate carboxylase (PC) activity and glycogenolysis in the liver. Unlike its effect on T2D mice, kaempferol effect in lean STZ-induced diabetic mice was not associated with changes …
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The regulation of secondary metabolism from Tolypocladium inflatum, a study on strain improvement in cyclosporin A productivity and its relation to growth and glucose metabolism
… higher production. Coarse control of the enzymes hexokinase (HK), phosphofructokinase (PFK) and pyruvate kinase (PK) in cell-free extracts of 'T. inflatum' was investigated. Decreased activities of HK, PFK and PK activity was observed in higher cyclosporin A-producing strains with probabilities of …
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The antidiabetic properties of four plants grown in India and KwaZulu-Natal, South Africa, suitable for diabetic management
… of Na/K ATPase and by assessing glucokinase and hexokinase activity by analysing liver and gastrocnemius muscle tissue. Results revealed that all four plants were reported to have protein, fats, glucose and starch, with the South African varieties showing higher protein content than the Indian …
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Unbiased global proteomic profiling of patient-derived meningiomas of all grades to identify molecular signatures of differentially expressed proteins and phosphoproteins.
… high-grade meningiomas was the glycolytic enzyme hexokinase-2, involved in cellular metabolism. In summary, we generated a proteomic thesaurus of meningiomas in order to decipher aberrantly expressed proteins and activated pathways; this body of knowledge will eventually lead to the identification …
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The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives
… technology, we identified the c-Myc oncogene and hexokinase as essential determinants of HAMLET sensitivity. HAMLET sensitivity was modified by the glycolytic state of tumor cells and HAMLET induced a metabolic paralysis in tumour cells. In paper II the initiating events for tumour cell death are …
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Localised Dosing and Nanodetection Using a Novel Scanning Ion Conductance Microscope and Its Application to Alzheimer's Disease
… a sensitivity of 10 micro molar and works as a hexokinase-cofunctioned electrolyte-gated organic field-effect-transistor. However no statistically significant results for ATP release have been obtained in the experiments performed to date. Overall this thesis describes new biophysical methods to …
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Nutrient-dependent effects of the autophagy-lysosomal inhibitor, Chloroquine, on cell death and lysosomal functionality
… unexpectedly, further glucose starvation or hexokinase inhibition fully rescued cell viability. The cytotoxic effects of CQ were found to be autophagy-independent as knockdown of ATG proteins did not mimic CQ. As the form of cell death in our model did not resemble classical caspase-dependent …
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Effects of Drought on Gene Expression in Maize Reproductive and Leaf Meristem Tissues as Revealed by Deep Sequencing
… of invertase genes, glucose signaling (hexokinase 1-dependent and independent), ABA-dependent and independent signaling, antioxidant responses, PCD, phospholipase C effects, and cell cycle related processes. This work was supported by the National Science Foundation Plant Genome Research …
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Diallel analysis of diplopodia ear rot resistance in maize and an assessment of the genetic variability of Stenocarpella maydis through isozyme analysis
… for esterase, two isolates were polymorphic for hexokinase and malate dehydrogenase and one isolate was polymorphic for hexose kinase. Fungi that have limited isozyme polymorphisms often are biotrophs or fungi with formae speciales which are usually limited to one host. These groups of fungi …
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Factors preventing the metabolism of carbohydrates by Bacillus sphaericus 2362
… cell extracts. These enzymes were: glucokinase, hexokinase, beta-galactosidase, and amylase. Growth of this bacterium on glycerol as a sole source of carbon implies the presence of the enzymes from the lower half of the Embden-Meyerhof-Parnas (EMP) pathway. Two enzymes of the upper half of the …
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ApoE2-Mediated Neuroprotection Against Alzheimer’s Disease: from Mechanism to Translation
… glycolytic function through upregulation of hexokinase 1 (HK1) protein expression and enzymatic activity as compared to ApoE4 neuron-like cells. Introduction of the ApoE2 gene, but not the ApoE3 gene, into the ApoE4 genotype significantly ameliorated ApoE4-associated glycolytic deficits. …
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