Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 214 for “"heterozygosity"”.
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Investigating the role of human genomewide heterozygosity as a health risk factor
… approaches to measure individual genome-wide heterozygosity (IGWH) and to investigate whether IGWH can be considered as a health risk factor or a protective factor in humans. Methods This study was based on two samples from isolated communities of Croatian Adriatic islands, with a total of …
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Analysis of the relationship between genomic instability, heterozygosity levels and phenotype in Saccharomyces cerevisiae
… structure by influencing the levels of genomic heterozygosity. While genomic instability processes can act to erode heterozygosity from the genome, natural selection may favor the maintenance of heterozygous alleles in cases where there is a positive correlation between heterozygosity and higher …
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Consequences of mitotic loss of heterozygosity on genomic imprinting in mouse embryonic stem cells
… cell lines depending on the mechanism of loss of heterozygosity (LOH) in that cell line. Certain genes analyzed, such as Peg10, Sgce, Peg1, and Mit1 showed abnormal expression in ES cell lines for which they were mUPD. These abnormal expression levels are similar to that observed in ES cells with …
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The generalized inbreeding coefficient and the generalized heterozygosity index in a recurrent selection program
… degree of variability; instead an index of total heterozygosity is required, and such an Index was derived. Formulas necessary to calculate both the inbreeding coefficients and the heterozygosity indexes were derived for the cases: one-locus, two-allele, random selection; k independent loci and …
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Breeding System, Heterozygosity, and Seed Germination in a Population of Missouri Bladder-Pod, Lesquerella Filiformis Rollins
… and to examine the fitness consequences of heterozygosity. Both multilocus and single-locus estimates of the outcrossing rate (tm=1.000, ts=0.996) indicate a primarily outcrossing species. Among viable seeds, the smaller seeds were more prone to germinate. However, neither seed size nor …
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Functional analysis of ANKRD11 and FBXO31: two candidate tumour suppressor genes from the 16q24.3 breast cancer loss of heterozygosity region.
Loss of heterozygosity (LOH) on the long arm of chromosome 16 is frequently observed during the onset of breast cancer. Our laboratory has recently identified both ANKRD11 and FBXO31 as candidate tumour suppressor genes in the chromosome band 16q24.3, which is the smallest region of overlap for …
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Development of DNA markers and the genetic analysis of seven populations of the freshwater mussel Lampsilis radiata siliquoidea (Bivalvia: Unionidae) in north central Minnesota
… investigated the influence of population size on heterozygosity in seven different sized populations of the freshwater mussel Lampsilis radiata siliquoidea (Bivalvia: Unionidae) in north central Minnesota. Random amplified polymorphic DNA (RAPD), heteroduplex, and single-stranded conformational …
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The role of heterozygous lysosomal storage disorder alleles as risk factors for dementia
… model (AppNL-G-F/NL-G-F). We hypothesised Hexb heterozygosity would hasten and/or exacerbate pathology and disease-related signs in AppNL-G-F/NL-G-F mice. The AppNL-G-F/NL-GF knock-in mouse was novel and not extensively characterised at the beginning of this PhD study. We therefore performed a …
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Η ετερογένεια των γ-αλυσίδων σε περιπτώσεις με αυξημένη εμβρυϊκή αιμοσφαιρίνη
… hemoglobin of Hellenic origin patients with a heterozygosity or homozygosity for β-thalassemia, heterozygosity for δβ-thalassemia, Hb Lepore, β-thal/HbS condition and normal newborns, was quantitated by alkali denaturation and further characterized by high pressure liquid chromatography. Data …
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Genomic improvement of nitrogen utilization efficiency in maize
… known that heterosis is related to the degree of heterozygosity in a hybrid and recent advances in genome-scale genotyping enable detailed estimates of heterozygosity. Thus, in an effort to understand the genetic mechanisms underlying heterosis and how they impact complex traits, we conducted an …
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Electrophoretic investigation of genetic characteristics in the pine vole
… jointly dependent at all 5 loci, but average heterozygosity was similar among the orchards (decreasing from 0.490 to 0.470 in sprayed orchards and from 0.548 to 0.494 in unsprayed orchards). The one incidence of increased endrin tolerance entailed no unique genetic component related …
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CHARACTERIZATION OF MICROSATELLITE LOCI AND PILOT POPULATION GENETIC ANALYSIS IN HICKORY SHAD, ALOSA MEDIOCRIS
… was extremely low. Estimates of observed heterozygosity were lower than expected heterozygosity. Significant population structure was detected among the six samples (FST = 0.093, p = 0.01). Effective population sizes were low (Ne ranged from 2 to 134). The lack of genetic diversity, …
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The conservation genetics of the Clanwilliam cedar (Widdringtonia cedarbergensis)
… relationship with genetic variation measured as heterozygosity. The populations were rated according to population size, density and isolation and correlated with heterozygosity to determine whether there was any relationship. Seventeen enzyme loci were resolved for each species. Estimates of …
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The Prince or the Depauperate? Population Genetics of the Rare, Closed-flower Erica occulta
… would have a low number of alleles and low heterozygosity. Given its floral morphology it was predicted to be a self-fertilising plant which may manifest as a further loss of heterozygosity and strong genetic isolation by distance.
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GENETIC DISSECTION OF MATURITY DATE IN PEACH AND APRICOT REVEAL A ROLE FOR CONSERVED GENE NETWORKS
… (about 256 Mb), diploidy (2n = 2x = 16) and low heterozygosity. Conversely apricot shows high levels of heterozygosity and consistent structural variations, limiting a direct knowledge transfer from peach. Maturity Date (MD) is a complex trait, influenced by multiple factors, both environmental …
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GENETIC STRUCTURE OF PINUS STROBUS L BASED ON FOLIAR ISOZYMES FROM 27 PROVENANCES
… Based on 12 loci, mean values of average heterozygosity, proportion of polymorphic loci and number of alleles per locus per provenance were .236, .69 and 2.01, respectively. By partitioning of total genetic diversity into its components, interprovenancial allele differentiation amounted to …
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The use of microsatellites as a surrogate for quantitative trait variation in conservation
… selection declines at the same rate as heterozygosity in microsatellite markers, during a population bottleneck. Experimental population bottlenecks were of two effective population sizes (Ne), Ne=2 for one generation and Ne=60 for 35 generations. Based on the effective population size, …
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Microsatellite-based genetic profiling for the management of wild and captive flamingo populations.
… often exhibiting high levels of polymorphism and heterozygosity. These loci are thus important genetic markers for identity, parentage and population studies. Here, six microsatellite loci were isolated from a microsatellite-enriched Caribbean flamingo partial genomic library. Two are compound …
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Genetic structure and disease prevalence of boreal toads (Bufo boreas) in Glacier National Park
… but—surprisingly—increased with individual heterozygosity. This finding suggests that dispersal may be facilitating the spread of disease because heterozygosity is highest where dispersal and gene flow are greatest.
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