Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"heteroresistance"”.
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Antibiotic Tolerance and Heteroresistance: Associated Fitness Costs and Potential in Evading Antibiotic Killing
… to withstand antibiotic killing, such as heteroresistance, can affect antibiotic treatment outcomes clinically. We found that vancomycin heteroresistance is associated with treatment failure and poor outcomes in coagulase-negative staphylococci (CoNS) from pediatric leukemia patients.</p> …
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Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
… population equally. This phenomenon is known as heteroresistance. Heteroresistance is defined as the presence of a heterogeneous population of bacteria with one or multiple subpopulations showing higher levels of antimicrobial resistance relative to the main population. This makes it more …
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Loss of the SAC Components SldA Kinase or SldB or in vitro Adaptation to Triazole Produces Aneuploidy Associated with Triazole Heteroresistance in Aspergillus fumigatus
<p>The opportunistic pathogen Aspergillus fumigatus represents the chief causative agent of human and animal invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the fungal biosynthesis of ergosterol, a vital component of …
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The evolution of virulence in Candida auris determined through experimental, ecological and epidemiological approaches
… tory clinical isolates, identifying features of heteroresistance and tol- erance associated with polyploidy (Chapter 5). Finally, I update the global genomic epidemiology of the ongoing C. auris outbreak across six continents using 12,644 strains, including seven clinical strains from the first …
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Microbiological, genomic and transcriptomic analyses of human tuberculosis lung cavities
… is poorly understood. The degree of heteroresistance in the human lung remains unclear. METHODOLOGY: Multi- and extensively drug-resistant TB (MDR- and XDR-TB) patients scheduled for therapeutic lung resection surgery in Cape Town were prospectively recruited. Biopsies were obtained …