Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"heterophilic"”.
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Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
… investigated in this thesis formed strong heterophilic bonds at three ectodomain alignments. Of the three, the inner bond (strongest) corresponding to full ectodomain overlap, did not exhibit much variation in either the homophilic or the heterophilic interactions. The two outer bonds …
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Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins
… E-cadherin expressing cells as a result of both heterophilic and homophilic binding. However, I also showed that lateral cadherin clustering is not a cadherin-specific response. These results are important because they suggest that cadherin-dependent differences in intracellular signaling may …
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Mine the node association: Dig into the essence of graphs
… association mining in dynamic graph; (3) heterophilic association mining in static graph; and (4) heterophilic association mining in dynamic graph. First, regarding homophilic association mining in static graph, we have reconciled the competing sampling strategies in existing network …
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Cadherin recognition and specificity
… the differences between cadherin homophilic and heterophilic interactions were investigated. The measurements showed that the properties of both heterophilic and homophilic bonds are similar. Surprisingly, Rac1 activation triggered by cadherin adhesion showed a greater response to homophilic than …
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Axon Guidance In The Mouse Olfactory System
… analysis of the δ protocadherins reveals novel heterophilic interactions between the extracellular domains of some family members, as well as heterophilic interactions between Pcdh10 and some classical cadherins. Furthermore, we identify the ability of the cytoplasmic domains of these proteins …
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Systematic evaluation of laying hen exposure to atmospheric ammonia
… long-term exposure study, intra- & subepithelial heterophilic infiltrates were increased in the ocular conjunctival (P=0.0005) and heterophilic infiltrates of the lungs (P=0.0371). After 25 wks of exposure, there was an increased blood heterophilic/lymphocyte ratio (P=0.001) in the exposed birds; …
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Cells and force transduction
… confirm that cadherins form both homophilic and heterophilic bonds, but homophilic cadherin ligation selectively triggers cadherin-associated RTK signals that mechanically reinforce homophilic, but not heterophilic cadherin adhesions, thereby stabilizing homophilic adhesions and amplifying …
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Cadherin specificity in adhesion and mechanotransduction
… and dissociation rates of homophilic and heterophilic cadherin bonds. Measurements conducted with chicken N-cadherin, canine E-cadherin, and Xenopus C-cadherin demonstrated that all three cadherins cross-react and form multiple, intermolecular bonds. The mechanical and kinetic properties …
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Mechanotransduction at cell-cell contacts
… transduction triggered by homophilic versus heterophilic cadherin bonds that could differentially influence cell mechanics. I further investigated the mechanism of force transduction at cadherin junctions, as described in Chapter 4 of this thesis. Chapter 4 specifically focused on the role of …
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Characterization of CEACAM1 Spatial Distribution, Self-association and Dynamics using High-resolution Microscopy Techniques
… cell surface glycoproteins involved in homo- and heterophilic intercellular interactions that control cellular growth, differentiation, tumourigenesis, inflammation and infection. There is growing evidence that CEACAM1 isoforms regulate the cellular response to CEACAM1-mediated interactions …
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Biophysical and Structural Studies of CNTNAP2
… postsynaptic membranes through homophilic and heterophilic interactions promoting synapse development, function, and plasticity. The synaptic adhesion molecules contactin 2 (CNTN2), and contactin associated protein-like 2 (CNTNAP2) have an emerging role at synaptic interaction networks. CNTNAP2 …
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Kinetics and regulation of the initial stages of cadherin-mediated adhesion
… (homophilic), and cadherins of different types (heterophilic) are quantified. The affinity changes are then correlated with cell aggregation results, demonstrating the threshold of affinity change required to see cells segregate. Multiple cell types which express cadherin were characterized. This …
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TIME, IDENTITY AND NATION IN GERMAN TRAVEL WRITING ON AFRICA 1848-1914
… regions of human experience, a positive, heterophilic desire to appreciate cultural heterogeneity; secondly, the opposite, expansionist, hegemonic aspirations fuelled by growing German nationalism and inter-European rivalry. The chief tool in analysing these conflicting tendencies is the …
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Topological Deep Learning: Graphs, Complexes, Sheaves
… cope with the challenges of oversmoothing and heterophilic graphs, which affect many existent graph models. Overall, this thesis introduces a novel topological perspective on deep learning for structured data, whose ramifications establish many new connections with algebraic topology.
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Investigation of minimum fragment requirement for mimicking n-cadherin mediated adhesion
… stable bond formation during homophilic and/or heterophilic interactions between cadherins via extracellular domains. In order to determine the minimum fragment of the extracellular domain required for binding to mimic full length cadherin and wild type cadherins expressed on cell surfaces, …
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Pathological characterization of natural Ophidiomyces ophiodiicola infection in wild-caught Lake Erie watersnakes: A standardized approach to documentation of disease
… comoribidities, including verminous pneumonia, heterophilic enteritis and splenitis, cutaneous mites, and coccidiosis. The most-prevalent comorbidity was decreased visceral adipose tissue stores which was not associated with cutaneous disease severity. The results of this study suggest that SFD …