Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 472 for “"heterologous"”.
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… Modulating the tumor microenvironment with heterologous non-human proteins opens avenues for enhanced therapeutic efficacies with a minimal chance of developing resistance . In this thesis we have explored therapeutic potential of engineered proteins derived from pathogenic bacteria …
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… Modulating the tumor microenvironment with heterologous non-human proteins opens avenues for enhanced therapeutic efficacies with a minimal chance of developing resistance . In this thesis we have explored therapeutic potential of engineered proteins derived from pathogenic bacteria …
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Intestinal delivery of heterologous peptides with lactobacilli
… lactobacilli were developed as a tool to deliver heterologous protein into the gastrointestinal tract. Lactobacillus spp. are a potential delivery vehicle for oral antigens because of their generally regarded as safe (GRAS) status, ability to persist in the acidic environment of human …
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Transient heterologous protein expression in green microalgae
… the gene's original source, it is referred to as heterologous protein expression. The baculovirus insect cell culture, yeast, and plants, such as Nicotiana benthamiana, are only a few of the commercial expression systems where this technology has been extensively used. These systems, however, …
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Catalytic antibodies elicited via homologous and heterologous immunization
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Physiological effects of heterologous expression of proteorhodopsin photosystems
… supplementing the cellular energy system of a heterologous host, paving the way for future engineering applications in photoheterotrophy.
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Expression and characterisation of biopharmaceuticals in heterologous expression systems
… were successfully established and optimised for heterologous expression in plants, bacteria and mammalian. The first aim of this thesis was the establishment of a protocol for the expression and purification of the anti-HIV antibody, 2F5, in plant suspension cultures (BY-2). Intact and pure …
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Insect expression systems : improving intracellular and heterologous gene expression
… To improve stable and regulated expression of heterologous genes in insect cells, work was undertaken to compare and characterise the transcriptional activity of a range of promoters successfully used in insect and mammalian systems. Of the promoters tested, Orgyia pseudotsugata MNPV (Op) ie-2 …
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Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
… We tested the hypothesis that pre-existing, heterologous flavivirus immunity, specifically from dengue (DENV) and Zika (ZIKV) viruses, limits YFV viremia and transmission by Ae. aegypti. We infected cynomolgus macaques with DENV or ZIKV, then challenged them 6-9 months later with YFV. We then …
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Investigating Epigenetics as a Mechanism to Regulate Bacterial Heterologous Expression
… biology since it can prevent the introduction of heterologous genes to new host organisms. Due to this, many studies that construct bacterial hosts for use in synthetic biology often remove these restriction-modification systems. There are no studies however that have attempted to optimize …
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Homology Cloning, Heterologous Expression and Characterization of A New Channelrhodopsin
<p>Channelrhodopsins are phototaxis receptors in the plasma membranes of motile unicellular algae. They function as light-gated cation channels and this channel activity has been exploited to trigger action potentials in neurons with light to control neural circuits (“optogenetics"). Four …
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Analysis of Spacer Region derived from Recombination between Heterologous loxPs
… loxP 간의 재조합 반응 시 spacer region 염기 서열을 분석한다. 또한 heterologous (mutant) loxP 간의 반응 시 spacer region의 염기 서열 분석을 통하여 Cre 매개 재조합 메카니즘의 이해를 넓힌다. 재료 및 방법 : 두 lox site 사이의 Cre 매개 재조합 반응으로 나타나는 spacer region의 염기 서열 분석을 위하여 새로운 벡터 pFGB를 제작하였다. 2272, M2, M3, M7, M11으로 총 25개의 pFGB-lox1/lox2 조합을 구성했다. Cre를 …
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Genetic Functions of Prophage: Interference With the Multiplication of Heterologous Bacteriophages
Made available in DSpace on 2014-12-05T21:45:25Z (GMT). No. of bitstreams: 1 0015236.pdf: 3975538 bytes, checksum: 5088a54a43f0def1f5fa218c36ae6270 (MD5) Previous issue date: 1955
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Metabolic engineering for the production of functionalized terpenoids in heterologous hosts
… and market variability. As such, production in heterologous microbial systems through metabolic engineering stands as an attractive alternative to truly natural production and allows for increased control over biosynthetic pathways enabling improved yields, titer, and productivity. The …
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Characterization and Heterologous Expression of Recombinant Drosophila melanogaster Fatty Acyl CoA Reductase
Insect genomes have multiple fatty acyl CoA reductases (FARs), which implies varying substrate and product profiles. However, very few of these FARs have been characterized. Expression of the FAR CG18031 from Drosophila melanogaster in Spodoptera frugiperda (Sf)9 cells will allow for functional …
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Cloning, Heterologous Expression, and Characterization of Human and Escherichia Coli Choline Dehydrogenases
Membrane bound choline dehydrogenase (CHDH) catalyzes the first committed step of choline oxidation to betaine-glycine in mammals and in some bacteria such as E. coli and P. aeruginosa . In mammals, it is an important source of one-carbon units for cytosolic folate- and AdoMet-dependent reactions, …
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Identifying Potential Agonists Of TRPA1 Using A Heterologous Expression System And Transgenic Mice
Chemical irritants stimulate the trigeminal nerve through many different receptor proteins, including TRP channels. TRPA1, a highly conserved TRP channel, is known to be activated by over ninety compounds. As TRPA1 is promiscuous in nature, it was considered a likely receptor for stimuli activating …
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