Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"heterodimerisation"”.
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Self-Assembly of Calix[4]Arene Amine Derivatives
… structures are present, namely the heterodimerisation form and the homodimerisation form. It is believed that due to the loss of the t-butyl groups early in the synthesis that this allows extra flexibility in the calix[4]arene unit, thereby allowing it to alternate between its …
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Charakterisierung fluoreszierender Varianten des Zytokinrezeptors gp130 hinsichtlich biologischer Aktivität und Dimerisierung mit molekularbiologischen und fluoreszenzspektroskopischen Methoden
… at least two molecules of gp130. LIF induces a heterodimerisation of gp130 and LIF-Receptor. The fluorescent proteins Cyan fluorescent protein (CFP) and Yellow fluorescent protein (YFP) derived from jelly fish are important tools in protein biochemistry. Fluorescence resonance energy transfer …
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Characterisation of the Arabidopsis mid-SUN proteins at the plant NE
… was also used to investigate mid-SUN homo- and heterodimerisation. ER-enrichment of AtSUN3 and AtSUN4 was confirmed by calculating the ratio of fluorescence intensity between ER and nuclear periphery. Additionally, a high-resolution confocal imaging technique used to determine protein …
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Molecular insights into signalling mechanisms within TGF-β superfamily
… assay that can test for transmembrane helix heterodimerisation that overcomes problems with existing similar assays. Overall, I have demonstrated that structural components of the TGF-β superfamily that were overlooked during previous studies have a significant impact on the structure of its …
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Localization and dimerization of the ABC half transporter rAbcb6 as compared to rAbcb7
… was darauf hindeutet, dass eine Heterodimerisation von diesen beiden Proteinen unwahrscheinlich ist.
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Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
… to either IRS1 or IRS2, and impaired heterodimerisation of p85$\alpha$ $\Delta$Ex11 with p110$\alpha$. Collectively, the data presented in this thesis contributes to the developing knowledge of PIK3R1-related diseases. In particular, these studies provided novel insights into the …
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Recognizing Lynch Syndrome by DNA Mismatch Repair Deficiency
… (MLH1+PMS2). In addition to sharing a common heterodimerisation protein, the roles of MutSα and MutSβ have been suggested to overlap in the repair of small insertion deletion loops. A germline mutation in MLH1, MSH2, MSH6 or PMS2 is most commonly the cause of LS. Mutation carriers have a …
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Investigating the role that Interleukin-10's receptor binding properties play in defining its biological activities
… that increased affinity for IL-10Rß enhanced heterodimerisation of IL-10Rα and IL-10Rß for both the monomeric and dimeric variants. This increased receptor complex assembly translated into increased STAT1 and STAT3 activation by the high affinity monomer compared to the wild type monomer. The …
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
… Ku70 DNA repair functions by facilitating the heterodimerisation with Ku86 to form the Ku complex. Furthermore, the nuclear localisation signal (NLS) that is involved in the retention of Ku70 in the nucleus is also located in this region. It was also demonstrated that the second DED (DED2) of …
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Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition
… with ß-tubulin in the pathway to aß-tubulin heterodimerisation. It maintains a soluble pool of ß-tubulin and can prevent premature polymerisation. This is a short helical protein, similar in structure to published homologues. The similarities and some distinct local features that may impact …
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Charakterisierung der Nicotiana tabacum bZIP-Transkriptionsfactoren BZI-2, BZI-3 und BZI-4 als Heterodimerisierungspartner von BZI-1
In dieser Arbeit wurden drei bZIP-Transkriptionsfaktoren, BZI-2, BZI-3 und BZI-4 isoliert und charakterisiert, die mit BZI-1 heterodimerisieren. Im Gegensatz zu BZI-1, das ubiquitär exprimiert wird, zeigen die anderen BZI-Proteine differentielle Expressionsmuster. BZI-2 wird vor allem in den …