Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"heterochromatin organization"”.
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Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
… periphery has long been recognized as a site of heterochromatin organization, where lamina-associated domains (LADs) play a crucial role in transcriptional repression and genome stability. However, the molecular mechanisms that tether LADs in human cells remain poorly defined. To address this …
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Role of ORCA and ORC in chromatin organization and DNA replication
… or individual subunits of ORC including heterochromatin organization, telomere and centromere function, centrosome duplication and cytokinesis. Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine …
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Maximum Entropy Optimization: a General Approach to Study Ordered and Disordered Proteins Reveals Key Features of Protein Phase Separation
… dictate these condensates' stability and spatial organization are not fully understood, and it remains challenging to predict their microstructures. Computational modeling could provide high-resolution structural characterizations of these condensates and help uncover physicochemical interactions …
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Role of ORCA/LRWD1 in the maintenance of telomere integrity
… maintained by the coordination of replication, heterochromatin, and DNA damage repair machinery. In this thesis, I describe how Origin Recognition Complex-associated (ORCA/LRWD1), regulates telomere integrity in Alternative Lengthening of Telomeres (ALT) -positive cells. In the absence of …
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Role of WD domain-containing proteins in cell cycle progression
… ORCA’s role in replication initiation and heterochromatin organization. In Chapter 2, I describe my work to map the binding sites of ORCA genome-wide by ChIP- seq method at specific time points of G1. ORCA associates with chromatin in a dynamic manner and ORCA binding regions are enriched …