Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"herpesviruses"”.
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
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IDENTIFICATION AND CHARACTERISATION OF POTENTIALLY NOVEL HERPESVIRUSES IN VERTEBRATE SPECIES
… viral attachment and entry into host cells. Herpesviruses have co-evolved with specific hosts and are extremely adapted to them; indeed, in these adapted hosts they establish a life-long latent and sub-clinical infection. However, various pathological manifestations can still arise in …
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T lymphocyte responses to equid herpesviruses 1 and 4 in horses
This thesis describes the development, optimisation and use of assays to measure equine herpes virus-specific proliferative and cytotoxic T lymphocyte (CTL) responses in the blood of horses. Equine T cell blast cells stimulated from peripheral blood mononuclear cells (PBMC) with pokeweed mitogen …
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Determining the role of the conserved Herpesviridae protein kinase (CHPK) in replication and transmission of avian herpesviruses
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Molecular basis oh herpes simplex virus entry into the cell and retargeting of the viral tropism for the design of oncolytic herpesviruses
… of viral tropism for the design of oncolytic Herpesviruses: • capable of infecting cells through the human epitelial growth factor receptor 2 (HER2), overexpressed in highly malignant mammary and ovarian tumors and correlates with a poor prognosis; • detargeted from its natural receptors, HVEM …
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Repurposing the human immunodeficiency virus (HIV) integrase inhibitor raltegravir for the treatment of felid alphaherpesvirus 1 (FHV-1) ocular infection
Herpesviruses infect many species, inducing a wide range of diseases. Herpesvirus-induced ocular disease, which may lead to blindness, commonly occurs in humans, dogs, and cats, and is caused by human alphaherpesvirus 1 (HHV-1), canid alphaherpesvirus (CHV-1), and felid alphaherpesvirus 1 (FHV-1), …
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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
… with naturally acquired influenza infection show herpesviruses are largely beneficial and improve illness outcome. Herpes simplex virus is associated with decreased duration of influenza virus shedding, and cytomegalovirus is associated with increased functional antibody titers and decreased …
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The role of heterochromatin markers in lytic human herpesvirus egress and maturation
The human herpesviruses are large, double-stranded DNA viruses known for their persistent latent phase. Within the herpesvirus family there are 3 subfamilies; alphaherpesviruses, classified as such because of their more rapid replication and latency in neurons; betaherpesviruses, known for slow …
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Structural and biochemical characterisation of pUL7 and pUL51, conserved tegument proteins required for efficient herpesvirus assembly
Herpesviruses are ubiquitous viral pathogens that infect all known vertebrates. It is estimated that over 90% of adults worldwide are infected with at least one of the nine human herpesviruses, which cause a wide range of morbidity and mortality. These viruses share a conserved assembly pathway, …
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Characterization of the Surface Proteins of the Anatid herpesvirus
… in molecular weights to those reported for other herpesviruses.
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Investigating the epidemiology of Terrapene herpesvirus 1 in freeranging eastern box turtle populations
Herpesviruses are ubiquitous, well described pathogens in captive chelonians worldwide, but their importance on free-ranging populations are less defined. In this thesis, a quantitative PCR was developed that detected a 58 base pair segment of the DNA polymerase gene segment of Terrapene …
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Structure of the GP16 ATPase from the φ29 dsDNA packaging motor
… in eukaryotic dsDNA viruses such as poxviruses, herpesviruses and adenoviruses. Encapsidation of bacteriophage φ29 DNA is driven by a phage-encoded molecular motor. This motor is powered by an oligomeric ATPase, gp16, or gene product 16, that converts energy obtained from ATP hydrolysis into …
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Impaired Control of Chronic Herpesvirus Infection in Tissue Resident Macrophages During Coinfection with Intestinal Parasite and Other Cell-intrinsic Herpesvirus Interactions
Gammaherpesviruses are chronic pathogens that infect lymphocytes, such as B cells, dendritic cells, and macrophages. Reactivation of gammaherpesviruses is thought to induce lymphomas and can be caused by a variety of signals, such as HDAC inhibitors. While some of these signals are known, it is …
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Construction of a Simian Immunodeficiency Virus Vaccine from Cynomolgus Macaque Cytomegalovirus
… that will permit the further understanding of herpesviruses as vaccine vectors and their potential application in humans.
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Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model
… vectors that can induce durable immunity. Herpesviruses, such as cytomegalovirus (CMV), show much promise as viral vectors, as they establish lifelong latency with periodic reactivation, enabling persistent expression of vaccine antigens. We propose that using CMV as a lifelong reactivating …
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Identification and characterization of low pH-triggered conformational changes in the herpes simplex virus glycoprotein B
Herpesviruses can enter host cells by pH-dependent endocytic pathways in a cell-specific manner. The role of pH in herpesvirus endocytosis is unclear. Herpes simplex virus (HSV) is a paradigm for virus membrane fusion via a complex of glycoproteins. HSV glycoproteins B, D and the heterodimer H-L …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
… poised to reactivate. Latency is unique to herpesviruses and key to HSV's success, but the molecular mechanisms that govern this state are unclear. A virus-encoded E3-ubiquitin ligase, Infected Cell protein 0 (ICP0), is often correlated with latency establishment but is detected in …
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
… viral latency in trigeminal sensory neurons by herpesviruses. TG-associated pathologies remain poorly understood in part due to a lack of human, scalable in vitro models of the ganglion. Human pluripotent stem cells can be differentiated towards three-dimensional organoids mirroring tissue …
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Characterization of the Interactions Between Kaposi’s Sarcoma-Associated Herpesvirus ORF57 and Its RNA Partners
… most common AIDS-associated malignancy. Like all herpesviruses, KSHV has evolved mechanisms to modulate both host and viral gene expression. The essential and multifunctional KSHV ORF57 protein has been reported to enhance viral gene expression at multiple levels including transcription, splicing, …
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Epidemiology of Emydoidea Herpesvirus 1 in free-ranging Blanding’s turtles (Emydoidea Blandingii) from Illinois
… of captive Emydid chelonians worldwide, novel herpesviruses (Terrapene herpesvirus 1, Emydid herpesvirus 1 and 2, and Glyptemys herpesvirus 1 and 2) have also recently been identified in apparently healthy free-ranging Emydid populations. The clinical significance of this finding in the absence …
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