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Showing 1 to 13 of 13 for “"herpesviridae"”.
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Determining the role of the conserved Herpesviridae protein kinase (CHPK) in replication and transmission of avian herpesviruses
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Investigating the epidemiology of Terrapene herpesvirus 1 in freeranging eastern box turtle populations
… herpesvirus 1 (Order: Herpesvirales; Family: Herpesviridae; Subfamily: Alphaherpesvirinae; Genus: Scutavirus). This assay was used to estimate prevalence of herpesvirus infection in 409 free-ranging eastern box turtles (Terrapene carolina carolina) from Tennessee and Illinois. The overall …
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Evolutionary History of Immunomodulatory Genes of Giant Viruses
… together with homologs from the unrelated Herpesviridae family, suggesting that inter-viral gene exchange can traverse vast evolutionary distances. The vast diversity of hosts infected by different NCLDV lineages suggests that these immunomodulatory genes play key roles that are useful to …
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MCMV interferiert mit der MHC-Klasse-I-Antigenpräsentation
… der Maus (MCMV) zählt zur Familie der Herpesviridae und hat verschiedene Strategien entwickelt, um dem Immunsystem des Wirts zu entgehen. Einer dieser Mechanismen beeinflusst die Antigenpräsentation durch MHC-Klasse-I-Moleküle und wird durch das virale Genprodukt von m152 vermittelt. …
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic …
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Detecting and defining immunity to human cytomegalovirus (HCMV) in health; combining QuantiFERON®-CMV and flow cytometry
… member of the beta-herpesvirus family (Herpesviridae), infecting approx. 83% of adults worldwide. Once infection has resolved, CMV enters a life-long latent state, with potential to reactivate. Infection is usually asymptomatic in healthy individuals, while severe disease can occur in …
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Characterization of Murine Cytomegalovirus m142 and m143 Essential Gene Products
… is a species-specific virus belonging to the Herpesviridae family. This DNA virus causes severe disease or even death in newborns and immunosuppressed patients. Murine CMV (MCMV) provides an opportunity to study the role of various viral products in replication and pathology in the natural …
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Molecular basis oh herpes simplex virus entry into the cell and retargeting of the viral tropism for the design of oncolytic herpesviruses
… example of virus receptor interaction in Herpesviridae family, and the prototype virus encoding multipartite entry genes. In fact, it encodes 11-12 glycoproteins and a number of additional membrane proteins: five of these proteins play key roles in virus entry into subsceptible cells. …
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The Effects of Levamisole, CORYNEBACTERIUM PARVUM, and Unblocked Lymphocytes on Mice Injected with Herpes Virus Type 2-transformed Cells
<p>The association between herpes simplex virus type-2 and carcinoma of the cervix is becoming increasingly strong (Rawls, et al., 1976 ; Rapp and Duff, 1974; Hollingshead, et al-, 1973). This study demonstrates the ability of certain known immunostimulators to beneficially· alter the immune status …
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IDENTIFICATION AND CHARACTERISATION OF POTENTIALLY NOVEL HERPESVIRUSES IN VERTEBRATE SPECIES
The Herpesviridae family includes a diverse group of viruses that can infect a broad spectrum of vertebrate hosts, ranging from fish to mammals. The structural unit of these viruses, known as the virion, contains a linear, double-stranded DNA genome that is encapsulated within an icosahedral …
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The PNUTS-PP1 Complex Acts as an Intrinsic Barrier to Kaposi's Sarcoma Associated Herpesvirus Gene Expression and Replication
Control of RNA Polymerase II (pol II) elongation is a critical component of gene expression in mammalian cells. The PNUTS-PP1 complex controls elongation rates, slowing pol II after polyadenylation sites to promote termination. The Kaposi's sarcoma-associated herpesvirus (KSHV) co-opts pol II to …
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Impaired Control of Chronic Herpesvirus Infection in Tissue Resident Macrophages During Coinfection with Intestinal Parasite and Other Cell-intrinsic Herpesvirus Interactions
Gammaherpesviruses are chronic pathogens that infect lymphocytes, such as B cells, dendritic cells, and macrophages. Reactivation of gammaherpesviruses is thought to induce lymphomas and can be caused by a variety of signals, such as HDAC inhibitors. While some of these signals are known, it is …
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Characterization of the Interactions Between Kaposi’s Sarcoma-Associated Herpesvirus ORF57 and Its RNA Partners
Kaposi's sarcoma-associated herpesvirus (KSHV; HHV-8) is a human gammaherpesvirus and the etiological agent of Kaposi's sarcoma (KS), the most common AIDS-associated malignancy. Like all herpesviruses, KSHV has evolved mechanisms to modulate both host and viral gene expression. The essential and …