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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 24 for “"herpes simplex virus (HSV)"”.

  1. The Effect of Orally Administered Butylated Hydroxytoluene on Herpes Simplex Keratitis

    Carson, Donald

    … in vitro inactivation of membrane enveloped viruses by Butylated hydroxytoluene (BHT). This study investigates the effect of orally administered BHT on primary infections of Herpes simplex virus (HSV) using rabbit corneas as the assay system. </p> <p>Assigned levels of BHT were incorporated …

    wku-diss Repository record

  2. Studies on the interaction of HSV-1 multifunctional protein ICP27 with the nuclear pore complex proteins

    Tabarraei, AlijanUniversity of Glasgow2009

    Herpes simplex virus (HSV-1) ICP27 is a multifunctional immediate early (IE) protein, required for expression of several early and late genes and acts at transcriptional and posttranscriptional levels. ICP27 contains both a nuclear localization signal and a nuclear export signal and shuttles …

    glasgow Repository record

  3. Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision

    Harryparsad, RushilDivision of Immunology2016

    … sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% respectively. Asymptomatic STIs may elevate the risk of HIV-1 acquisition by recruiting HIV-1 target cells to the foreskin. The higher permeability of the inner foreskin may …

    cape-town Repository record

  4. Investigation of Infectious Disease Associations with Cognitive Impairment using Electronic Medical Records

    Littleton, Tehya MarieThe University of Texas Medical Branch at Galveston2025

    … between six clinically important infections—Herpes simplex virus (HSV), syphilis, Chlamydia trachomatis, coronavirus disease 2019 (COVID-19), cytomegalovirus (CMV), and human immunodeficiency virus (HIV)—and subsequent cognitive impairment. On June 12, 2025, we queried the global TriNetX …

    utmb Repository record

  5. Identification and characterization of low pH-triggered conformational changes in the herpes simplex virus glycoprotein B

    Dollery, Stephen2016

    Herpesviruses can enter host cells by pH-dependent endocytic pathways in a cell-specific manner. The role of pH in herpesvirus endocytosis is unclear. Herpes simplex virus (HSV) is a paradigm for virus membrane fusion via a complex of glycoproteins. HSV glycoproteins B, D and the heterodimer H-L …

    vcu Repository record

  6. Interazioni tra le glicoproteine D, B, H ed L critiche per la fusione indotta dal virus Herpes simplex

    Forghieri, Cristina <1975>Alma Mater Studiorum - Università di Bologna2008

    … (gD, gB, gH, and gL) are required for herpes simplex virus (HSV) entry into the cell and for cell-cell fusion in transfected cells. gD serves as the receptor-binding glycoprotein and as the trigger of fusion; the other three glycoproteins execute fusion between the viral envelope and …

    bologna Repository record

  7. Identification of macrophage phenotypes and evaluation of their role in the immunopathogenesis in animal model of Behçet’s disease

    A.K.M., Mostafa Anower2013

    … alternatively activated (M2) macrophages. In a herpes simplex virus (HSV)-induced BD mouse model, it has confirmed the abundant expression of the M1 phenotype (CD16/32) compared to the M2 phenotype(CD23). For M1/M2 phenotypic transformation in vivo normal mice, recombinant interferongamma …

    ajou Repository record

  8. Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification

    Mok, WilsonMassachusetts Institute of Technology2008

    … characterize the distribution of a therapeutic herpes simplex virus (HSV) vector in solid tumors. The model showed that the spread of virus following intratumoral injection is severely limited by rapid binding and limited diffusion. Importantly, the model demonstrates that an improvement in …

    mit Repository record

  9. Modeling of [¹⁸F]-FHBG in tumor and normal tissues

    Slutsky, Emily DaleMassachusetts Institute of Technology2007

    … of tumors has led to the emergence of oncolytic virus therapy. Viruses have been engineered to preferentially target tumor cells. The efficiency and safety of this cancer treatment is dependent upon selective viral replication within cancer cells. In order for viral oncolysis to be successful in …

    mit Repository record

  10. A Role for the HSV Tegument Protein pUL16 in Modulating Cellular Energy Metabolism during HSV-2 Infection

    Denniston, Nick2025

    … pUL16, is implicated in several processes during Herpes simplex virus (HSV) infection, including virion morphogenesis and cell-to-cell spread of infection. Recent literature has also demonstrated that HSV-1 pUL16 localizes to distinct regions of mitochondria. Consistent with these findings, our …

    queens Repository record

  11. The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells

    Reske, A.UCL (University College London)2009

    Herpes Simplex Virus (HSV) – 1 also known as Human Herpes Virus (HHV) – 1 is a common infectious agent of humans which can cause a wide variety of clinical outcomes, ranging from mild mucocutaneous lesions to long term morbidity and possible mortality. Viral entry into cells requires the …

    ucl Repository record

  12. Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models

    Sun, Yusha2025

    … to glioma remain unclear. We leveraged rabies virus and herpes simplex virus (HSV)-based transsynaptic tracing techniques in the rodent brain to define a whole-brain connectome of GBM-projecting neurons. We found that, remarkably, GBM receives inputs from all over the brain and are innervated …

    penn Repository record

  13. Viral delivery of recombinant growth hormone to rescue effects of chronic stress on hippocampal learning

    Saenz, Christopher MMassachusetts Institute of Technology2012

    … and determine whether infusion of a modified herpes simplex virus (HSV) carrying the recombinant rodent growth hormone (GH) would be sufficient to restore normal hippocampal function. After 21 days of chronic immobilization stress (CIS), animals received bilateral infusions into the dorsal HIP …

    mit Repository record

  14. Gene regulation and function of ICP0 in herpes simplex virus infected cells

    Liu, Mingyu2009

    Herpes simplex virus (HSV) is a clinically important virus, whose life cycle alternates between productive replication and latency. Infected cell protein 0 (ICP0) is generally believed to play a key role in determining the outcome of HSV infections. Synthesis of ICP0 promotes the productive …

    siu-theses Repository record

  15. Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity

    Smith, Gordon BrawnMassachusetts Institute of Technology2010

    … has not been established. Here we develop a herpes-simplex virus (HSV) vector to express a peptide (G2CT) in visual cortical neurons designed to block AMPAR internalization by hindering the association of the C-terminal tail of the AMPAR GluR2 subunit with the AP2 clathrin adaptor complex. We …

    mit Repository record

  16. Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma

    Zhang, Ying Zhang2016

    … a melanoma vaccine expressing MAAs within herpes simplex virus (HSV) glycoprotein D (gD), which blocks the inhibitory BTLA/CD160-HVEM pathway. Compared to a non-gD vaccine, the gD-adjuvanted vaccine enhances CD8+T cells to low avidity epitopes and prolongs survival of tumor-bearing mice. gD …

    penn Repository record

  17. Multi-modal imaging of herpesvirus infection

    Nahas, KamalUniversity of Cambridge2022

    Herpes simplex virus (HSV)-1 is a large, enveloped DNA virus that undergoes a complex assembly pathway in the cell. Capsids assemble in the nucleus, cross the nuclear envelope into the cytoplasm by budding and fusion through the nuclear membranes, and acquire a proteinaceous ‘tegument’ layer in the …

    cambridge Repository record

  18. The pedagogy of the clinic: health professionals and women with viral sexually transmitted infections

    Cook, CatherineResearchSpace@Auckland2010

    … two most common viral STIs, the human papilloma virus (HPV) and the herpes simplex virus (HSV). To consider the effects of the myriad beliefs that inform clinical teaching I draw from poststructuralist feminist discourse theory. For data collection I used in-depth email interviews, a research …

    auckland-ms Repository record

  19. Structural and biochemical characterisation of pUL7 and pUL51, conserved tegument proteins required for efficient herpesvirus assembly

    Butt, BenjaminUniversity of Cambridge2022

    Herpesviruses are ubiquitous viral pathogens that infect all known vertebrates. It is estimated that over 90% of adults worldwide are infected with at least one of the nine human herpesviruses, which cause a wide range of morbidity and mortality. These viruses share a conserved assembly pathway, …

    cambridge Repository record

  20. Mechanisms of cell adhesion regulation by herpes simplex virus

    Barrow, HenryUniversity of Cambridge2023

    Herpes simplex virus (HSV)-1 is a highly prevalent human pathogen that establishes a life-long infection. HSV-1 promotes its replication and spread by expressing multi-functional proteins that extensively remodel the host cell. Three such proteins are pUL21, pUL7 and pUL51. pUL21 is a viral …

    cambridge Repository record

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