Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 394 for “"hereditary"”.
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Genetic Exploration of Hereditary Immune Diseases
<p>An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases, rheumatoid arthritis and systemic sclerosis are two of them. My study focuses on these two diseases. Our hypothesis is that mutated genes lead …
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Mitochondrial dysfunction in hereditary optic neuropathies
MITOCHONDRIAL DYSFUNCTION IN HEREDITARY OPTIC NEUROPATHIES Mitochondrial pathologies are a heterogeneous group of clinical manifestations characterized by oxidative phosphorylation impairment. At the beginning of their recognition mitochondrial pathologies were regarded as rare disorders but indeed …
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Hereditary and inborn etiology of pediatric cancer
… small subset of individuals develop OS due to a hereditary predisposition syndrome such as Li Fraumeni, Retinoblastoma, or Rothmund-Thompson syndrome. Mutations in the TP53, RB, and RECQL4 genes are highly penetrant and can confer up to a 90% chance of developing OS. We hypothesized that single …
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Managing Susceptibility to Hereditary Breast and Ovarian Cancer
… carriers, managed their susceptibility to hereditary breast and ovarian cancer (HBOC). Thirty North American women ranging in age from 22 to 60 years responded to open-ended interviews. These interviews were analyzed using constant comparative method to generate a grounded theory. Managing …
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Genetic basis of hereditary persistence of fetal haemoglobin
… haemoglobinopathies. The frequency and range of hereditary persistence of fetal haemoglobin (HPFH) in the UK population was determined which was otherwise unknown. All 4 categories of deletion mutations were identified and demonstrated the high frequency of deletional HPFH in UK patients. Four …
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Cross-pressures, communication behavior and the hereditary vote
Thesis (M.A.)--Michigan State University. Dept. of Communication, 1967
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On Schur algebras, Doty coalgebras and quasi-hereditary algebras
… coalgebra A(n,r), and S(n,r) we know to be quasi-hereditary. Moreover, we call a finite dimensional coalgebra quasi-hereditary if its dual algebra is quasi-hereditary and hence, in the above cases, the Doty Coalgebras D_(n,p)(r) are also quasi-hereditary and thus have finite global dimension. We …
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The psychological impact of carrier status in hereditary disorders
… at risk of being sole carriers of an X-linked hereditary disorder, Duchenne muscular dystrophy. Previous research most often assessed global self-esteem, thus problems in particular domains (such as future parental role or desirability as a mate) have generally been overlooked. Herein, a …
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Hereditary multiple exostosis : a study in abnormal bone growth
Hereditary multiple exostosis is a generalised, heritable disorder of bone, characterised by the appearance of numerous cartilagecappecl exostoses at the juxta-epiphysial regions of the endochondral skeleton. The condition was apparently known even in Hunter's day and most of its characteristic …
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Optimal control of linear hereditary systems with quadratic criterion.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 1973.
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A transgenic mouse model of hereditary motor and sensory neuropathy
… (CH) IS the most severe demyelinating form of Hereditary Motor and Sensory Neuropathies and manifests at birth in human. Some subtypes of CH are due to dominant mutations in the gene coding for PO glycoprotein, which functions as a homophilic adhesion protein, responsible for compaction of …
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Signalling pathway of FBXO7 and its role in hereditary Parkinsonism
… with Mendelian autosomal inheritance (10-15%). Hereditary and sporadic PD share important clinical and neuropathological features, and there is reasonable hope that dissecting molecular pathways of PD gene products will have more general implications for the pathophysiology of PD associated …
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Chinese Hereditary Mathematician Families of the Astronomical Bureau, 1620-1850
… digitized archival materials to reconstruct the hereditary mathematician families of the Astronomical Bureau in Qing China. The research found several patterns and strategies that these hereditary mathematician families exhibited during their long careers at the Astronomical Bureau. It found that …
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Hereditary haematological disorders in the Greek population of Cape Town
It is a recognized fact that most well defined population groups have their own typical pattern of inherited disorders. The genetic conditions most commonly found in Greek persons are the thalassaemias, glucose-6-dehydrogenase (G-6-PD) deficiency and, to a lesser extent, certain of the …
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Hereditary non-polyposis colorectal carcinoma (HNPCC) : morphological and immunohistochemical studies
Families with hereditary non-polyposis colorectal carcinoma (HNPCC) are not uncommon along the West-Coast of South Africa. These patients present with early onset carcinomas mostly colorectal, predominantly in the right colon. They may develop tumours of other organs, including uterus, breast, …
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Assessing Patient Attitudes to ward Genetic Testing For Hereditary Hematologic Malignancy
… 15 genes have been identified to predispose to hereditary hematologic malignancy (HHM). Although the diagnostic yield of germline analysis for leukemia is similar to solid tumors, referral for genetic evaluation in adults with leukemia is underperformed. Identifying HHM is important for …
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