Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"heptad repeat"”.
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Functional Characterization Of The Cholera Toxin Promoter Of vibrio Cholerae
… biotypes contain a varying number of heptad repeats that are also H-NS binding regions and it was previously thought that H-NS needs to be completely displaced from the DNA to relieve its repressive role. However, the binding sites of ToxT and H-NS overlap in a small region of DNA and …
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Charakterisierung der beta-Untereinheit von heterotrimeren G-Proteinen aus Physcomitrella patens
… Eigenschaften von beta-Untereinheiten wie die Heptad-repeat-Domäne und WD40-repeats auf und wird von Antikörpern gegen Arabidopsis Gb erkannt. PpGb1 liegt als Einzelkopie im Genom von Physcomitrella vor und wird in sehr geringem Maß exprimiert. Das andere Gen, PpGb2, wird zwar transkribiert, …
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Characterization and Inhibition of the Dimer Interface in Bacterial Small Multidrug Resistance Proteins
… conserved 90GLxLIxxGV98 small residue heptad repeat. Upon investigation of the large hydrophobic residues in this motif by substituting each large residue to Ile, Leu, Met, Phe, and Val, we determined that Hsmr efflux function relies on an optimal level of dimerization. While some …
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Heterotrimeric coiled-coils as viral fusion protein mimics
… of biological activity. It is characterized by a heptad repeat of amino acids that serve to form both the hydrophobic core and electrostatic interfaces of the coiled-coil. Previous work in our lab showed the viability of designing a self-assembling heterotrimeric coiled-coil by sole manipulation …
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Regulation of the Human Parainfluenza Virus (hPIV3) Fusion Protein
… (F) protein is regulated with a focus on the heptad repeat B (HRB) region of the F protein located in the ectodomain, directly adjacent to the transmembrane domain. This region has been suggested to play important roles in the initiation of fusion</p> <p>(Gravel 2003) as well as in the …
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DNA Recognition by Helix-Loop-Helix Proteins
… Myc oncoproteins, the HLH motif is followed by a heptad repeat of hydrophobic amino acids, or "leucine zipper" (Z). My X-ray crystallographic structure determination at 2.9Å resolution of a dimer of the b/HLH/Z domain of the mammalian oncoprotein Max bound to its target DNA revealed that this …
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Genetics and functions of the SARS coronavirus spike protein
… domain of the S glycoprotein amino terminal heptad repeat, the predicted fusion peptide, or adjacent but distinct regions, severely compromised S-mediated cell-to-cell fusion, while intracellular transport and cell-surface expression were not adversely affected. Surprisingly, a carboxyl …
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The functions of the RNA polymerase II CTD in transcription and RNA processing
… c-terminal domain (CTD) that consists of tandem heptad repeats with the consensus sequence of Tyr-Ser-Pro-Thr-Ser-Pro-Ser (Y1S2P3T4S5P6S7). Somewhat reflecting the complexity of the organism, the number of repeats varies, from 26 in yeast to 52 in vertebrates. The CTD, intensively phosphorylated …
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Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses
… including the inward disposition of the heptad repeat helices and gp120 protomers towards the trimer axis. Taken together, the data from Chapter 2 and Chapter 3 highlight an underappreciated Env compactness mechanism of HIV-1 resistance to neutralising antibodies and these data may be …