Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"hepatotoxic"”.
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Quantitative analysis of cytokine-induced hepatocellular death in the context of hepatotoxic therapeutics
… and certain therapeutics individually induce hepatotoxicity, there is little understanding of how they jointly regulate the complex cellular signaling network governing hepatocellular death. In this thesis, we explored the signaling mechanisms governing the cytokine-induced hepatocellular …
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Structure/toxicity relationships and fate of low molecular weight peptide toxins from cyanobacteria
… the parent toxin; but the GSH conjugate remained hepatotoxic and hepatospecific in its effects.
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Identification of a gap junction communication pathway critical in innate immunity
… damage, inflammation, and death in response to hepatotoxic drugs. Co-administration of a selective pharmacologic Cx32 inhibitor with hepatotoxic drugs significantly limited hepatocyte damage and sterile inflammation, and completely abrogated mortality. These finds suggests that co-formulation of …
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The synthesis of pyrrolizidine alkaloids
… compounds. A number of the alkaloids are hepatotoxic and carcinogenic, but some derivatives have potentially useful physiological properties;A promising but seldom used reaction in alkaloid synthesis is the amidoalkylation of enolizable carbonyl derivatives. The reaction involves …
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Transcriptional response and DNA adduct analysis of murine liver exposed to aflatoxin B₁ by Jeanette Louise Allen Fiala.
… most other species, are highly sensitive to the hepatotoxic and carcinogenic effects of AFB1; unlike other species, however, maturation of the mouse is accompanied by a transition to almost complete resistance to the toxin over a short period of a few weeks. This study compares age-specific …
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Investigating Induced Pluripotent Stem Cells for Tissue Engineering and Hepatotoxicity Applications
… to obtain, while cell lines exhibit reduced hepatotoxic sensitivity. iPSC-Heps are being investigated as an alternative option as they are derived from a continuous, stable source and are able to maintain their original donor genotype, which opens the door for patient-specific studies. …
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Liver Injury in HIV-positive Patients on Antituberculosis and/or Antiretroviral Therapy – Assessing Causality
… ART and ATT, with a median of 6 potentially hepatotoxic drugs per case. Sensitivity and specificity of the RUCAM in identifying a probable/certain drug cause of liver injury compared with expert panel review was 11% and 85% respectively. Implicated drugs (times ranked probable/certain by …
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Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection
… mice show a high degree of resistance to the hepatotoxic effects of this compound compared to their wild-type counterparts, in part, due to a partial recovery of hepatic glutathione levels. The ability of GSTP1 to mediate glutathione homeostasis was demonstrated in vitro, where silencing of …
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Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa
… liver dysfunction. Patients are on multiple hepatotoxic drugs, may have multiple opportunistic infections, systemic sepsis and hepatic TB immune reconstitution disease also plays a role. Anecdotally, these patients are complex to manage, require frequent specialist input, spend a long time in …
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The Fumonisin B1-Fed Rat as a model for liver injury, oval Progenitor') cell proliferation, and carcinogenesis
… the fungus Fusarium moniliforme in maize, and is hepatotoxic and hepatocarcinogenic in rats. The goal ofthis dissertation was to characterise the FB1-fed rat as a model for liver injury and carcinogenesis, and to examine the role of oval ('progenitor') cells during these processes. Male Fischer …
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The fumonisin B₁-fed rat as a model for liver injury, oval ('progenitor') cell proliferation, and carcinogenesis
… the fimgus Fusarium moniliforme in maize, and is hepatotoxic and hepatocarcinogenic in rats. The goal of this dissertation was to characterise the FB₁-fed rat as a model for liver injury and carcinogenesis, and to examine the role of oval ('progenitor') cells during these processes. Male Fischer …
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Investigation of novel methods to remove the cyanotoxin, Cylindrospermopsin, from drinking water.
… cyanobacterial species. Cylindrospermopsin is hepatotoxic and acts as a strong inhibitor of protein synthesis. The increasing occurrence of toxic cyanobacterial blooms is of major concern, particularly within drinking water supply systems. Therefore, the investigation of more effective water …
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Science Based Authentication of Dietary Supplements: Studies on the Chemical Constituents, Analytical Method and Biological Activities of Scutellaria Spp and Pfaffia Paniculata
… skullcap were raised due to the reports of hepatotoxic reactions after skullcap-containing preparations were ingested. Therefore, this plant was listed in the FDA Poisonous Plant Database and has been classified as an “Herb of Undefined Safety”. Meanwhile, it was reported to be adulterated …
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Molecular and bio-analytical characterisation as a means to understand genetic diversity within Kenyan Aspergillus flavus strains
… produce mycotoxins that are carcinogenic, hepatotoxic and teratogenic immunosuppressing agents in both human and animals. Kenya frequently experiences outbreaks of aflatoxicosis with the worst occurring in 2004, which resulted in 125 deaths. This study sought to find possible reasons for …
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The destruction of the cyanobacterial toxin microcystin-LR by semiconductor photocatalysis.
… group of toxins are the microcystins which are hepatotoxic resulting in haemoraging and tumour promotion in the liver. There have been several reports of human poisonings resulting from the presence of cyanotoxins in potable waters, some of which have resulted in fatalities. The most frequently …
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Environmental Degradation of Aflatoxins and Genetic Diversity of Aspergillus Section Flavi with a Focus on Mozambique
Aflatoxins are potent hepatotoxic, carcinogenic, genotoxic secondary metabolites produced by species in Aspergillus section Flavi that contaminate foods and feeds worldwide. Aflatoxin contamination of staple crops is endemic in Mozambique, and the country has one of the highest rates of liver …
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Establishing species-specific 3D liver microtissues for repeat dose toxicology and advancing in vitro to in vivo translation through computational modelling
… a relevant and representative in vitro model for hepatotoxicity has therefore expanded. The aim of this thesis is to characterise a novel 3D microtissue model that, in the future, aims to provide a better in vitro platform to assess liver toxicity after repeat-dose exposure to xenobiotics. This is …
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An in vitro and in vivo hepatotoxicity study of an aspalathin- rich green rooibos extract
Hepatotoxicity is an undesirable condition of the liver, often occurring due to the interaction of drugs. Although different methods have been employed in the diagnosis of drug-induced hepatotoxicity, none have accurately proven the hepatotoxic effect of drug-drug interactions or drug-herb …
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Prognostische Bedeutung und ätiologische Aspekte von Leberfunktionsstörungen bei internistischen Intensivpatienten
… half of the applied substances had a potencially hepatotoxicity (47,5%; n=133). Patients of goup IV were applied the highest number of these drugs (X=7,4). Especially compared to the patients without liver dysfunction (X=4,8 potentially hepatotoxic drugs) there was a significant difference. On the …
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Toxicology and herb-drug interaction of selected anti-hypertension plants used by lay persons in Northern KwaZulu-Natal (South Africa)
… the results showed that Sarcophyte sanguinea was hepatotoxic at the concentration of 100 μg/ml. Apart from Hypoxis hemerocallidea which had moderate hepatotoxicity, the aqueous extracts of the most frequently used medicinal plants were non-toxic thus considered safe to use as a traditional …
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