Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"hepatoma"”.
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Biochemical pharmacology of nucleotide metabolism in rat hepatoma
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Defect of Mitochondrial Translation Machinery Enhances Hepatoma Cell Invasiveness
… is associated with tumoral behavior in SNU hepatoma cells. 10 2. Mitochondrial protein homeostasis is associated with mitochondrial dysfunction. 12 3. Mitochondrial translation machinery defect may be a key event in mitochondrial dysfunction in hepatoma cells 14 4. Mt-TMD-related invasive …
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Regulation of mitochondrial respiration by LDHB suppression in hepatoma cell lines
… and mitochondrial respiratory defects in hepatoma cells. In this study, we aimed to investigate how LDHB suppression is linked with mitochondrial respiratory dysfunction. When LDHB expression was suppressed by siRNA-mediated knockdown, cellular oxygen consumption rate was significantly …
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Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2
Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the …
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Sulforaphane sensitizes TRAIL-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated upregulation of DR5
… induces rapid apoptosis in TRAIL-resistant hepatoma cells. Neither TNF-α- nor Fas-mediated apoptosis was sensitized in hepatoma cells by cotreatment with SFN, suggesting that SFN can selectively sensitize cells to TRAIL-induced apoptosis but not to apoptosis mediated by other death …
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Effect of mitochondrial respiratory defecton hepatocellular carcinoma :Involvement of mtOGG1 and NUPR1
… of mitochondrial DNA repair enzyme in hepatoma cell growth. To address this, it was employed several SNU hepatoma cells, which had been classified as harboring mitochondrial respiratory defects or not in a previous study. Interestingly, SNU cells with declined mitochondrial respiratory …
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Coordinated Control of Liver-Specific Genes in Cultured Cells from Mice and Rats
… fresh livers, primary hepatocyte cultures, and hepatoma cell lines, derived from mice or rats. The transcription rates of many different liver-specific but no common mRNAs were found to decline sharply within 24 hours when hepatocytes from the liver were explanted and placed into primary …
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Hepatitis B Virion and cccDNA Formation in Primary Tupaia Hepatocytes and Human Hepatoma Cell Lines upon HBV Genome Transduction with Replication-defective Adenovirus Vectors and in vivo Infection of Tupaias
… It was shown that these cells, like the human hepatoma cell lines HepG2 and HuH7, are efficiently transduced and produce all HBV gene products required to generate the secretory antigens HBsAg and HBeAg, replication-competent nucleocapsids, and enveloped virions. It was further demonstrated …
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TIMP-1: Zelluläre Funktion und Beeinflussung der Genexpression von Matrix-Metalloproteinasen in humanen Hepatomzellen
… HepG2 cells as well as TIMP-1 overexpressing hepatoma cells. In all cases the activation of the kinases was not influenced by TIMP-1. The changed cell morphology (nest shaped growth) of TIMP-1 overexpressing cells was not due to an extended expression of cell cycle inhibitor p21. Instead an …
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Studies on Taxol Resistance Induced by HBx Viral Oncoprotein
… were important in taxol response of HBV-related hepatoma cell lines,which were established from primary HCC tumors. Taxol-induced celldeath in Chang cells was triggered by caspase-independent cell death pathways. In contrast, celldeath in ChangX-31 and ChangX-34 was occurred by caspase-dependent …
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Untersuchungen zur Rolle von Zytokinen bei der Beta-2-Mikroglobulin-Synthese in verschiedenen humanen Zelltypen
… regulators of beta-2-M gene expression in human hepatoma cells, T-lymphocytes and monocytes. Methods. HepG2 and HuH7 human hepatoma cells, Jurkat T-cells, monocytic MonoMac6 cells, primary human monocytes and synoviocytes were stimulated with IL-1-beta, IL-6, interferon-alpha (IFN-alpha), …
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Mitochondrial respiratory defects induces claudin 1 expression via ROS-mediated HSF1 activation
… Interestingly, we found that SNU human hepatoma cells with mitochondrial dysfunction have high level of Cln-1 expression. In those HCC cells, Cln-1 played a key role in regulating invasiveness. Cln-1 expression was also observed in human hepatocellular carcinoma tissues. In this study, …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
… whether IFN-λ1 inhibits HBV replication in human hepatoma cell lines and whether HBV modulates expression of CRF2-12, a subunit of IFN-λ1 receptor. In addition, I wanted to establish ELISA for IFN-λ1 to examine HBV mediated modulation of IFN-λ1 production. Methods: I produced IFN-λ1 using E.coli …
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Development and analysis of an in vitro model of inflammatory cytokine-mediated idiosyncratic drug hepatotoxicity
… system using alternatively in both a human hepatoma cell line and primary rat hepatocytes to study toxic effects in a background reflecting in vivo inflammatory conditions. This background incorporates bacterial lipopolysaccharide (LPS) administration along with inflammatory cytokines (tumor …
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Regulatory Mechanisms of Mitotic Catastrophe Induced by Doxorubicin
… induced by high doses of doxorubicin in human hepatoma cells. And we examined the role of p21 in the prevention of doxorubicin-induced mitotic catastrophe (or multinucleation) to understand the regulatory mechanisms of mitotic catastrophe in human colorectal carcinoma cells. MATERIALS AND …
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Expression and Functional Analysis of Hepatitis B Virus DNA Polymerase
… except polymerase, were cotransfected to hepatoma cells, all chimeras were incompatible for replication. Interestingly core particle formation varied in chimeric DNA polymerase construct transfected cells. This result suggests that the primary sequence of chimeric DNA polymerase may affect …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
… TG secretion in transfected enterocytes and hepatoma cells. We therefore examined the impact of apoA-IV expression on VLDL particle dynamics in stably transfected McA-RH7777 hepatoma cells. Expression of apoA-IV caused an increase in TG secretion that was attributed to 10.1 nm increase in …
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
… human and animals, however, the level of AR in hepatoma is variable and their exact effects are still poorly explained. Therefore, we investigated the role of androgen receptor (AR) in HCC development. METHOD: To investigate the potential role of AR in hepatoma, Huh7-AR and Huh7-V cell lines …
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Albumin Transcriptional Regulation
… of albumin gene transcription in a series of rat hepatoma cell lines, which each transcribe the albumin gene at a different rate. An analysis of the expression of the rat transthyretin gene was also included in this series of experiments, and the question of coordinate hepatocyte gene control was …
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