Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"hepatocyte nuclear factor"”.
-
Sumo and Ubiquitin Ligases Regulate Hepatocyte Nuclear Factor - 1 Beta Transcriptional Activity
Hepatocyte nuclear factor-1beta (HNF-1β ) is a homeodomain-containing transcription factor that regulates tissue-specific gene expression in the kidney, liver, and other organs. Humans with heterozygous mutations of HNF-1β develop maturity-onset diabetes of the young type 5 (MODY5) associated with …
-
Functional characterization and regulation of liver transcription factors hepatocyte nuclear factor 3.
… and regulation of liver transcription factors hepatocyte nuclear factor 3.
-
P53 Maintains Hepatic Cell Identity During Liver Regeneration
… p53 cooperates with the master regulator of hepatocyte differentiation, HNF4α, to induce 78% of these genes, including a number of liver-enriched transcription factors such as CCAAT/enhancer binding protein beta (CEBPβ), hepatocyte nuclear factor 6 alpha (HNF6α), hepatocyte nuclear factor 6 …
-
Genetic and Molecular Analysis of Islet-and Liver-Enriched Transcription Factors in Metabolism and Development
… are caused by mutations in transcription factors that include hepatocyte nuclear factor (HNF)-4α, HNF-1α, PDX-1, HNF-1β, and NEURO-D1/BETA-2. In addition, genetic defects in the glucokinase gene, the glucose sensor of the pancreatic β-cells, and the insulin gene also lead to impaired …
-
ModuleFinder : a computational model for the identification of Cis regulatory modules
… the binding of sequence- specific transcription factors (TFs) to genomic DNA binding sites (BSs). This thesis presents a rigorous scoring scheme, implemented as a C program termed "ModuleFinder", that evaluates the likelihood that a given genomic region is a cis regulatory module (CRM) for an …
-
The Role of HNF4A in Germ Cell Tumor Development
… YST driver genes. We have determined that the Hepatocyte Nuclear Factor 4 alpha locus, which resides in this region, is frequently amplified in YSTs. Overexpression of HNF4A in an undifferentiated GCT line is sufficient to drive extraembryonic endodermal gene programs. This endodermal program …
-
Developmental and Growth Hormone Regulation of the Expression of Liver-Enriched Transcription Factors in Bovine Liver
… expression of the liver-enriched transcription factors (LETFs). To study the potential involvement of LETFs in the regulation of gene expression in the bovine liver, we cloned the cDNA fragments of nine bovine LETFs, including hepatocyte nuclear factor (HNF)-1Æ Ã , 1Æ Ã , 3Æ Ã , 3Æ Ã , 3Æ Ã , 6, …
-
Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene.
… in two evolutionarily related proteins, human factor IX and protein C. These regions were found to be bound specifically by potentially the same or a similar protein; but the identity of the protein could not be confirmed as either PEA3 or Ets1, although transactivation data from HepG2 cells …
-
Identification and characterization of genes expressed by the midbrain dopaminergic neurons
… been further characterized in this study: The hepatocyte nuclear factor 3 a (HNF3a), the neuronal and B-cell differentiation factor, Olf-1/Ebf, and the neuregulin receptor, ErbB4. HNF3a is expressed in the precursors of the mDA neurons at E9 and continues to be expressed in the postmitotic …
-
Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
Hepatocyte nuclear factor-1Beta (HNF-1Beta) is a POU/homeodomain-containing transcription factor that regulates tissue-specific gene expression in the liver, kidney, pancreas, and other epithelial organs. During kidney development, HNF-1Beta is expressed in renal collecting ducts and all segments …
-
THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
… (FXR) is a ligand activated transcription factor belonging to the nuclear receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation of bile acids, lipid homeostasis, glucose metabolism, and tumor suppression in liver and …
-
Identification and Characterization of Transcriptional Regulatory Elements for Liver-Specific Expression of Rabbit CYP2C Genes
… motif of a liver-enriched transcriptional factor hepatocyte nuclear factor 4 (HNF-4), since it was recognized by a nuclear protein with the same tissue distribution, DNA binding specificity and immunochemical reactivity as those of HNF-4. The CYP2C2 promoter-luciferase constructs containing …
-
A Study of Mouse Peri-Implantation Morphogenesis
… cell sequencing analysis and assessment of hepatocyte nuclear factor 1β knock-out embryos, that fail to mature the primitive endoderm, I could uncover a novel, direct signalling interaction between epiblast and visceral endoderm required for epiblast survival following egg cylinder …
-
The use of human pluripotent stem cells to model HNF1B-associated diabetes
Heterozygous mutations in the transcription factor, hepatocyte nuclear factor 1B (HNF1B), result in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms that underlie development of diabetes in HNF1B mutation carriers are still not …
-
Genetic and immunological risk factors of gestational diabetes mellitus
… was to study the genetic and immunological risk factors that increase susceptibility to GDM. First, we investigated whether autoimmunity and genetic variants affecting insulin secretion or action, or both, contribute to the development of GDM. We found that GDM was associated with the presence of …
-
Mechanisms of Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression in Liver
… hormone (GH) regulates insulin-like growth factor-I (IGF-I) gene expression in liver. Previous studies have suggested that GH regulation of IGF-I gene expression in liver is mediated by binding of the transcription factor signal transducer and activator of transcription (STAT) 5 to four …
-
Investigation of a pancreatic derived progenitor cell population for use in regenerative medicine
… growth arrest that can be induced by multiple factors, including telomere dysfunction associated with replication and oxidant stress. Senescence of stem cell, or progenitor, populations has been proposed as a factor in impaired tissue homeostasis and a mechanism of ageing. In addition, cellular …
-
Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
… The most effective targets are likely to be factors essential for maintaining ccRCC cell phenotypes and survival across all tumour subclones. Transcription factors (TFs) are appealing candidates as they are key determinants of cellular phenotypes, including in cancer. There is growing …