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Showing 1 to 20 of 51 for “"hepatocyte growth factor"”.

  1. Regulation of hepatocyte growth factor receptor endocytic trafficking

    Ning LiThe University of Texas Medical Branch2006

    The Hepatocyte Growth Factor Receptor (HGFR/cMet) is a receptor tyrosine kinase that is essential for multiple cell responses, including cell proliferation, survival, motility and branching morphogenesis. Normal HGFR signaling regulates embryonic development, organ regeneration and wound healing, …

    utmb Repository record

  2. hepatocyte growth factor inhibits glial scar formation and

    정, 수령2011

    Formation of glial scars physically impedes growth of regenerating axons following CNS injuries such as spinal cord trauma. Glial scars also produce various species of chondroitin sulfate proteoglycans (CSPGs) that act as a potent inhibitor of axon growth. Thus, inhibition of glial scar formation …

    ajou Repository record

  3. Prevascularization-free Primary Subcutaneous Transplantation of Xenogeneic Islets Co-encapsulated with Hepatocyte Growth Factor

    Yang, Sin-YuKyoto University2021

    kyoto Repository record

  4. The Hepatocyte Growth Factor Effect of Matrix Metalloproteinases Expression in 3-Dimensionally Cultured Endometrial Cancer Cells

    박, 영한2011

    Master

    ajou Repository record

  5. Up-modulation of Hepatocyte Growth Factor/ c-Met Signaling by Protein Kinase C-g and its Mechanism

    김, 율2011

    … activity of c-Met, the receptor for hepaotcyte growth factor (HGF). However, specified roles by PKC isoenzymes on the regulation of HGF/c-Met signaling have never been addressed yet. In this study, attempts have been made to investigate the effect of PKC-γ, an isoenzyme of PKC, on the HGF/c-Met …

    ajou Repository record

  6. Met Inactivation by S-allylcysteine Suppresses Migration and Invasion of Nasopharyngeal Cancer Cells Induced by hepatocyte growth factor

    조, 오연2016

    … HONE1 treated with SAC (0, 10, 20, or 40 mM) and hepatocyte growth factor (HGF). This study showed that SAC could suppress the migration and invasion of HNE1 and HONE1 cell lines by inhibiting p-Met. An increase of migration and invasion induced by HGF and its decrease in a dose dependent manner …

    ajou Repository record

  7. The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.

    Al-Waleedi, Saeed A.University of Bradford2010

    Androgens are the main regulators of human hair growth stimulating larger, terminal hair development e.g. beard and causing scalp balding, androgenetic alopecia. Hair disorders cause psychological distress but are poorly controlled. Androgens probably act by altering regulatory paracrine factors …

    bradford Repository record

  8. Green Tea Polyphenol Epigallocatechin-3-gallate Inhibits Hepatocyte Growth Factor-Induced Tumor Cell Migration and Invasion In Vitro and In Vivo

    신, 윤혜2011

    " 간세포성장인자(hepatocyte growth factor,HGF)와 그 수용체인 Met의 과 활성화는 많은 종류의 종양의 발생과 진행에 관여하는 것으로 알려져 있다. 본 연구에서는 HGF/Met 신호전달체계를 효과적으로 억제하는 물질을 찾아보고자하였고 녹차의 성분 중 생체에 영향을 주는 중요한 polyphenol인 Epigallocathechin-3-gallate(EGCG)가 HGF/Met 신호체계를 효과적으로 억제할 수 있다는 것을 발견하였다. EGCG는 HGF에 의한 Met의 활성 방식이 autocrine이든 …

    ajou Repository record

  9. Activation of Ca<sup>2+</sup>-activated K<sup>+</sup> Channels and Cell Migration by Hepatocyte Growth Factor/Scatter Factor in Madin-Darby Canine Kidney Cells.

    Jin, Min2002

    <p>Hepatocyte Growth Factor/Scatter Factor (HGF/SF) stimulates migration of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on …

    etsu Repository record

  10. Regulation of Hgf Expression By Δegfr-Mediated C-Met Activation In Glioblastoma Cells

    Garnett, Jeannine2013

    <p>Overexpression of the hepatocyte growth factor receptor (c-Met) and its ligand, the hepatocyte growth factor (HGF), and a constitutively active mutant of the epidermal growth factor receptor (∆EGFR/EGFRvIII), occur frequently in glioblastoma. c-Met is activated in a ligand-dependent manner by …

    uthsc Repository record

  11. Nuclear Translocation of Met Via Internet Mechanism

    CHEN, MEI-KUANG2015

    … in breast cancer cells. Here, we show that hepatocyte growth factor (HGF) as well as hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) can induce nuclear translocation of full-length MET holoreceptor via a membrane-bound vesicle transport mechanism in breast cancer cells. Our findings provide a …

    uthsc Repository record

  12. Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments

    Varela, Jennifer Rico2017

    … cells to external signaling of Epidermal Growth Factor (EGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF-BB), and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and immunocytochemistry to identify receptor activation in MB …

    cuny Repository record

  13. Epithelial Tubular Fusion, Measuring Interconnection, and the Quest for Solving the Continuity Problem

    López-García, Isabel Alejandra2025

    … of candidate effectors. One such candidate was hepatocyte growth factor (HGF), which has known roles in cell migration, tubulogenesis, and cell proliferation. Addition of HGF robustly induced interconnection of adjacent spheroids. The proliferative effect of HGF neither promoted nor inhibited …

    utswmed Repository record

  14. Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma

    Laudermilch, Chelsea LeeVirginia Tech2007

    … gene microarray studies were conducted. Hepatocyte growth factor (HGF), interleukin 1 beta (IL1Β), and insulin-like growth factor 2 (IGF2) were elucidated as genes that were significantly expressed in GD12 placenta. These genes are similar in that they are all connected to the Jak-Stat …

    vt Repository record

  15. The role of fibrolast-derived cytokines on melasma

    김, 지연2011

    … radiation, sex hormone, and genetic predisposing factors, however, the exact mechanism of pathogenesis is not clearly demonstrated. Previous studies have been bringing focus into the pigmentation formed by interaction between keratinocytes and melanocytes. Recently, it was reported that dermal …

    ajou Repository record

  16. The role of PAK6 in HGF-induced prostate cancer cell migration

    Fram, SallyKing's College London2012

    … single cells adopting a migratory morphology. Hepatocyte growth factor (HGF) signalling is known to induce cell-cell dissociation and is associated with prostate carcinoma progression. HGF-induced cell-cell dissociation and migration require the activity of the Rho family GTPases Rho A, Racl …

    kings Repository record

  17. Targeting c-Met for therapy

    Wong, JulinUniversity of Dundee2011

    … which is activated by its only ligand, the hepatocyte growth factor (HGF). Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met and HGF knock-out mice are embryonic lethal. During …

    dundee Repository record

  18. Function and Regulation of the Cell Fate Determinant Numb in Polarized Epithelial Cells

    Lau, Kimberly2010

    … chelating agents. Loss of Numb potentiates hepatocyte growth factor (HGF)-induced lamellipodia formation and cell dispersal – early steps in epithelial-mesenchymal transition (EMT). In Numb-depleted cells, Rac1-GTP loading is enhanced, which corresponds with increased rate in loss of …

    toronto-retro Repository record

  19. Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development

    Thelin, MartinDepartment of Experimental Medical Science, Lund Univeristy2012

    … to be partially mediated by presentation of hepatocyte growth factor to the MET receptor by IdoA. Furthermore, DS-epi1-silenced cells had malfunctioning disassembly of adhesion complexes and abnormal cytoskeleton architecture. During brain development, DS-epi2 is known to be highly expressed. …

    lund Repository record

  20. The role of heparin and heparin-binding growth factors in pre-eclampsia

    Nazir Ahmad Mohamad, F.Middlesex University2016

    … hypothesis that expression of heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in pathophysiology of …

    middlesex Repository record

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