Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"hepatocyte differentiation"”.
-
Developing a clinically applicable hydrogel for the treatment of liver disease
… in these fields are the immaturity of lab-grown hepatocytes and mini-livers, and the sub-optimal biomaterials available for tissue engineering and cell delivery. For example, Matrigel is the most commonly used matrix in hepatocyte differentiation from pluripotent stem cells and liver organoid …
-
Cloning and Estrogen Regulation of the Retinol Binding Protein Messenger-Rna of Xenopus Laevis
… retinol, is likely to play an important role in differentiation. The findings of these investigations indicate that the RBP gene is activated coordinately with liver ontogeny and RBP gene activation may be a very early event in hepatocyte differentiation.
-
Quantitative analysis of cell decision processes in response to inflammatory cues and their role in mediating genotoxicity in hepatocytes
… study sought to elucidate changes that influence hepatocyte decision processes under conditions of chronic inflammation by using a set of extracellular signals, both soluble and matrix-related, which can be varied systematically to create a diverse range of intracellular signaling states and …
-
P53 Maintains Hepatic Cell Identity During Liver Regeneration
… liver may result in a decreased activity of differentiation-specific cellular processes and in attenuation of hepatic cell identity. Remarkably, p53 cooperates with the master regulator of hepatocyte differentiation, HNF4α, to induce 78% of these genes, including a number of liver-enriched …
-
O-GlcNAcylation: A key regulator of hepatic proliferation and differentiation
… that O-GlcNAcylation regulates hepatic differentiation and liver regeneration and protects against the development of hepatocellular carcinoma (HCC). To investigate the role of O-GlcNAcylation in liver pathobiology, we studied mice with knockout (KO) of OGT or OGA specifically in …
-
The Localization of Glucose-6 Phosphatase in Developing Rat Liver: A Histochemical and Biochemical Study
… of glucose-6-phosphatase activity in rat hepatocytes during a period of rapid cell and membrane differentiation was studied by electron microscopic histochemistry. Livers from animals 4 days before to 1 day after birth were perfused with 2% glutaraldehyde in the presence of 6 mM …
-
A Systems Approach to Studying the Differentiation of Stem Cells Towards Hepatocytes
… to become any specific cell type, such as hepatocytes. A robust and efficient process for expansion and differentiation to generate large quantities of functional hepatocytes from stem cells will be essential to establishing a stem cell bioprocess in the future for therapeutic and …