Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"hepatocyte culture"”.
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Identifcation and stablization of a novel 3D hepatocyte monolayer for hepatocyte-based applications
… of 3D spheroids was discovered when the hepatocytes attach to the substrata as monolayer but exhibiting many characteristics of the 3D spheroids, but without the limitations of the 3D spheroids. We coined the name of b 3D hepatocyte monolayerb to indicate its monolayer morphology as well …
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Increased differentiation properties in two- and three-dimensional coculture of hepatocytes and liver epithelial cells by a novel quantitative functional liver assay
… into the hepatic plates, and differentiate into hepatocytes. In an attempt to model this process in vitro, we established and quantitatively assayed the differentiation properties of a strain of rat liver epithelial cells (LEC), lig8, grown in coculture with mature liver cells in a three …
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Microvessel structure formation in a 3D perfused co-culture of rat hepatocytes and liver endothelial cells
… are not adequately captured by current in vitro hepatocyte culture methods. A 3D perfused microreactor previously demonstrated superior hepatic functional maintenance than conventional 2D cultures, and was hypothesized to provide an environment favorable to endothelial cell maintenance and …
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Tissue-engineered liver microreactor as an in vitro surrogate assay for gene delivery
… preventing the extrapolation of successful cell culture results into animals. This phenomenon has also been documented in the specific case of liver where standard hepatocyte culture systems fail to reliably predict the in vivo performance of gene delivery vectors. This is possibly a consequence …
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Platforms for exploring host-pathogen interactions in hepatitis C virus infection
… virus (HCV) mounts a chronic infection of liver hepatocytes that causes substantial morbidity and mortality. An understanding of host-virus interactions will drive the development of therapeutics, but research is restrained by available experimental tools. Due to the cost and unreliability of …
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Coordinated Control of Liver-Specific Genes in Cultured Cells from Mice and Rats
… and common mRNAs in fresh livers, primary hepatocyte cultures, and hepatoma cell lines, derived from mice or rats. The transcription rates of many different liver-specific but no common mRNAs were found to decline sharply within 24 hours when hepatocytes from the liver were explanted and …