Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 288 for “"hepatocyte"”.
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Identifcation and stablization of a novel 3D hepatocyte monolayer for hepatocyte-based applications
… of 3D spheroids was discovered when the hepatocytes attach to the substrata as monolayer but exhibiting many characteristics of the 3D spheroids, but without the limitations of the 3D spheroids. We coined the name of b 3D hepatocyte monolayerb to indicate its monolayer morphology as well …
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Substratum control of hepatocyte aggregate morphology
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1997.
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
… carcinoma development. Using the Resistant-Hepatocyte model (RH model) of rat hepatocarcinigenesis, we found downregulation of THRβ1 and THRα1 in most of early preneoplastic lesions and of HCCs. THRβ1 and, to a lesser extent, THRα1 downregulation was observed only in preneoplastic lesions …
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LIVER FIBROSIS IMPAIRS HEPATOCYTE TRANSDUCTION BY AAV VECTORS
… suggests that AAV-mediated gene transfer to hepatocytes may be hampered by liver fibrosis, but knowledge about AAV vector interactions with fibrotic livers is still very limited. In the present study, we investigated hepatocyte transduction and biodistribution of AAV8-based vectors, commonly …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
The Hepatocyte Growth Factor Receptor (HGFR/cMet) is a receptor tyrosine kinase that is essential for multiple cell responses, including cell proliferation, survival, motility and branching morphogenesis. Normal HGFR signaling regulates embryonic development, organ regeneration and wound healing, …
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hepatocyte growth factor inhibits glial scar formation and
… regeneration following spinal cord injury. Hepatocyte growth factor (HGF), which was originally identified as a mitogen for hepatocytes, has been shown to strongly suppress fibrosis of internal organs such as liver and kidney. However, its role in the regulation of CNS glial scars has not …
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Defining metabolic zonation as a determinant of hepatocyte plasticity
… experimental evidence suggests that mature hepatocytes have the capacity for transdifferentiation in order to contribute to biliary repair; however, it remains unknown whether all hepatocytes possess this propensity or whether lineage plasticity is zonated within the lobule. This study aimed …
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The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis
… tissue in the liver. Even though the number of hepatocytes seems to be enough to maintain liver function, hepatic failure is one of the main causes of death in the patients with liver cirrhosis. The role of adult hepatocytes as contributors to the hepatocytes dysfunction and liver cirrhosis is …
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Carbohydrate-derivatized poly(ethylene oxide) hydrogels for hepatocyte adhesion
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Single-cell Transcriptome Profiling Reveals Hedgehog Critically Regulates Hepatocyte Resiliency
… liver injury that develops when fatty hepatocytes experience lipotoxicity) or cirrhosis (the end result of maladaptive efforts to repair NASH that replace lipotoxic hepatocytes with scar).Hence, it is critical to improve understanding of the mechanisms that cause hepatic steatosis …
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Control of hepatocyte morphology and function by the extracellular matrix
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1992.
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Effects of Liver Extracellular Matrix Gel Stiffness on Primary Hepatocyte Function
… of cells. Primary liver epithelial cells, or hepatocytes, are easily isolated in large quantities. However, these cells quickly lose viability and function once removed from the native organ. In order to support hepatocyte phenotype in culture, decellularized liver matrix was incorporated into …
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Development Of Scaffold Architectures And Heterotypic Cell Systems For Hepatocyte Transplantation
… the difficulty of assembling three dimensional hepatocyte cultures of a useful size, while maintaining full cell viability, an issue which is closely related to the high metabolic rate of hepatocytes. In this study, we first compared two designs of highly porous chitosan-heparin scaffolds seeded …
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The Golgi Complex of the Hepatocyte: Isolation and Partial Enzomological Characterization
<p>The elements of the Golgi complex of the hepatocyte are characterized by their content of 30-80m osmiophilic particles, which have been identified by others as very low density lipoprotein. The vast majority of such particles in the cell are in the elements of the Golgi complex. Moreover, the …
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Functional characterization and regulation of liver transcription factors hepatocyte nuclear factor 3.
… and regulation of liver transcription factors hepatocyte nuclear factor 3.
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Sumo and Ubiquitin Ligases Regulate Hepatocyte Nuclear Factor - 1 Beta Transcriptional Activity
Hepatocyte nuclear factor-1beta (HNF-1β ) is a homeodomain-containing transcription factor that regulates tissue-specific gene expression in the kidney, liver, and other organs. Humans with heterozygous mutations of HNF-1β develop maturity-onset diabetes of the young type 5 (MODY5) associated with …
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T3-induced hepatocyte proliferation requires β-catenin and is protein kinase A dependent
… translocation of β-catenin in pericentral hepatocytes with concomitant increase in cyclin-D1 expression. T3 administration to wild-type (WT) mice resulted in increased hepatocyte proliferation, however no mitogenic response in hepatocytes to T3 was evident in the hepatocyte-specific …
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