Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 235 for “"hepatocellular carcinoma"”.
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RNA Therapeutics for Fibrolamellar Hepatocellular Carcinoma
<p>Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer characterized by a recurrent fusion of the heat shock protein DNAJB1 and the catalytic subunit of protein kinase A (PRKACA). Due to limited efficacy of conventional treatments such as chemotherapy and radiation my work explored …
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Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver …
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
… were performed to determine the role of THRs in hepatocellular carcinoma development. Using the Resistant-Hepatocyte model (RH model) of rat hepatocarcinigenesis, we found downregulation of THRβ1 and THRα1 in most of early preneoplastic lesions and of HCCs. THRβ1 and, to a lesser extent, THRα1 …
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Analysis of Exome Sequencing in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the type of cancer difficult to classify and analyze despite the high occurrence, because it displays a high level of tumor heterogeneity with complex etiology. For unbiased analysis of HCC with diverse tumorigenic backgrounds, a genomewide study that does not …
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Mechanisms of Reversible Sorafenib Resistance in Hepatocellular Carcinoma
… is the only approved treatment for advanced hepatocellular carcinoma (HCC) patients. Its efficacy is further hindered by intrinsic (upfront) and acquired drug resistance (initial response and subsequent relapse) and a lack of alternative therapies. Our laboratory previously demonstrated using …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Currently, there is limited knowledge of neoplastic transformation of hepatocytes in HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver …
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IDENTIFYING THE ROLE OF TIP60 IN HEPATOCELLULAR CARCINOMA
… I investigated the role of TIP60 in HBV-induced Hepatocellular Carcinoma, which is the primary malignancy of the liver and accounts for high mortality rate. It was observed that TIP60, a tumor suppressor implicated in multiple cancers, is downregulated in cells expressing HBx, an oncogene of HBV. …
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Pathogenic Characterization and Therapeutic Development for Fiblrolamellar Hepatocellular Carcinoma
<p>Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer that primarily affects adolescents and young adults. There are no known successful systemic chemotherapies for this disease, and thus, surgery is the only potential path to a cure in patients with FLC. Once the disease has grown …
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Role of Hydroxy acid oxidase 2 (Hao2) in hepatocellular carcinoma
… of this enzyme in mouse, rat and human hepatocellular carcinoma (HCC). Results: Our microarray analysis, performed in the liver of rats subjected to the Resistant Hepatocyte (R-H) model, revealed that Hao2 was among the most down-regulated genes in HCCs developed, 14 months after …
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Identification of novel transcripts in hepatocellular carcinoma using RNA-seq
… transcripts which might play functional roles in hepatocellular carcinoma (HCC) using reference based assembly method, which revealed 20 novel candidate transcripts. With those candidate transcripts, I predicted whether they have functions involved in cancer progression. Firstly, I identified …
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Surgical Strategy of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus
… The long-term outcomes of resection for hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) have not been well assessed. This study intended to research the surgical strategy of HCC patients with BDTT. Methods: From February 1994 to December 2012, 877 HCC patients …
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Investigating the Heterogeneity of Tumor Associated Macrophages in Human Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a liver cancer and is one of the leading causes of cancer death worldwide. Despite significant efforts in treating HCC, such as with the use of novel immune checkpoint inhibitors, the overall response rate remains low. This may be partly attributed to the lack of a …
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Proteomic Analysis of WNT Signaling and Metabolism of Fibrolamellar Hepatocellular Carcinoma
<p>Fibrolamellar hepatocellular carcinoma (FLC) is a rare form of liver cancer that primarily affects young adults and adolescents.Although characterized as a subvariant of hepatocellular carcinoma (HCC), we have shown it is distinct based on its pathogenesis, patient population and drug response. …
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CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
… infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients using an oligo-bead-based …
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Bone Metastasis from Primary Hepatocellular Carcinoma: Chararcteristics of Soft Tissue Formation
간세포암에 의한 골전이는 소수의 문헌을 통해 연부조직을 형성하여 골융해를 유발하는 것으로 알려져 있다. 여타 다른 원발성 암에 의한 골전이와 마찬가지로, 간암에 의한 골전이의 주 치료법은 방사선치료이나 치료 후 증세 완화의 정도는 다른 골전이보다 떨어지는 경향이 있다. 본 문헌에서는 1994년 10월부터 2004년 12월까지 아주대병원 방사선종양학과로 의뢰된 간세포암에 의한 골전이를 진단받은 환자들의 병력 기록 및 영상학적 검사 결과를 검토하여 간세포암에 의한 골전이의 성상을 규명하고 그 특징이 방사선치료에 미치는 영향에 대해 …
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Health-Related Quality of Life and Adjustment in Patients with Hepatocellular Carcinoma
… of this thesis were to explore the impact of hepatocellular carcinoma (HCC) on patients’ health-related quality of life (HRQOL), the significant predictors of adjustment outcomes, as well as to establish an adjustment model in patients with HCC. This thesis included three studies: systematic …
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Hepatocellular Carcinoma Image-Guided Intervention: Quantitative Characterization of Reagents For Thermochemical Ablation
… minimally invasive therapy under development for hepatocellular carcinoma, a leading cause of cancer death worldwide. TCA utilizes acid-base chemistry delivered simultaneously to induce local ablation when administered. When delivered via a mixing catheter placed directly into the tumor, acid …
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The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
… with doxorubicin is commonly used to treat hepatocellular carcinoma (HCC), but has limited efficacy due to a high level of resistance. The factors that determine the sensitivity to TACE-doxorubicin are unknown. FOXO3 is a multifunctional transcription factor that plays a role in determining …
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