Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"hepatoblasts"”.
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Generation and characterisation of primary and pluripotent stem cell-derived human hepatoblast organoids
… like the in vivo counterpart. Importantly, hepatoblasts are the first stem cell type of the liver and thus, they provide a new platform to study liver organogenesis. In this dissertation, the aim is two-fold. Firstly, to exploit the properties of HBOs for dissecting the signalling pathways …
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INVESTIGATIONS ON POTENTIAL OF UMBILICAL CORD LINING STEM CELLS FOR IN VITRO MODELS
… closely resembled the in vivo differentiation of hepatoblasts to hepatocytes, and the HLCs have functionally active cytochrome 3A4 enzyme. This is a novel report of an in vitro obesity model and functional HLCs derived from human UCLSCs.
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Modelling human liver bud development in vitro
… which strongly resemble 5/6pcw human foetal hepatoblasts. Moreover, by examining cell:cell interactions I found that early 2D HepBud cultures mimic the niche of cellular interactions of the developing liver bud, implicating cellular complexity as the key to generating bonafide hepatoblast …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …