Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"hepatitis C virus (HCV)"”.
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
Hepatitis C virus (HCV) is a major human pathogen and the leading cause of cirrhosis and liver cancer worldwide. HCV entry is clathrin- and pH-dependent, and requires CD81, Scavenger receptor BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be …
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"So How Did You Get That?": Experiences of Individuals Living with Hepatitis C Virus (HCV)
… and societal levels. How do individuals with Hepatitis C Virus (HCV), a culturally invisible disease, experience their illness? This dissertation examines the illness careers of 53 men and women with HCV through in-depth interviews. I explore how individuals experience their illness through an …
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DEFINING THE ROLE OF LIPID DROPLET SCAFFOLDING PROTEINS IN HEPATIC STEATOSIS INDUCED BY HEPATITIS C VIRUS CORE PROTEIN
Hepatitis C Virus (HCV) is an enveloped RNA virus responsible for 170
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The severity and activity of liver disease in chronic hepatitis C infection
Infection with hepatitis C virus (HCV) is the cause of 90% of cases of non -A, non -B hepatitis. Chronic HCV hepatitis is at least initially an asymptomatic illness, but a proportion of patients will develop symptomatic, complicated disease. The most common complications are hepatic cirrhosis and …
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Hepatitis C: A Perspective Through the Social Ecological Model
<p>Hepatitis C virus (HCV) is a major global public health problem. The Center for Disease Control and Prevention (CDC) estimates that the Hepatitis C virus (HCV) affects 3.2 million Americans and 500 million people from a global standpoint (CDC, 2012). HCV contributes to significant morbidity and …
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Secondary Metabolite Production By An Endophytic Bacillus sp. from Platanus Occidentalis
… by reviewing natural product inhibitors of the hepatitis C virus (HCV). The secondary metabolite production of the endophytic B. amyloliquefaciens was investigated under a variety of fermentation conditions. It was discovered that the endophyte produces rapamycin, a molecule previously reported …
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<b>Integrating Qualitative Inquiry and Cost-Effectiveness Modeling to Inform Equitable Hepatitis C Care Implementation</b>
… dissertation evaluates the cost-effectiveness of hepatitis C virus (HCV) elimination strategies among people who inject drugs (PWID) in rural and local public health settings. Using economic-epidemiological modeling, the research assesses interventions including expanded testing and treatment, …
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Resistance to hepatitis C virus : potential genetic and immunological determinants
… Population studies of those at high risk for hepatitis C virus (HCV) infection suggest that a HESN phenotype exists. There is a growing body of evidence for protective immunity, which allows clearance of HCV without seroconversion, and proof-of-principle evidence from in vitro studies that …
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The grapefruit flavonoid naringenin as a Hepatitis C virus therapy : efficacy, mechanism and delivery
Hepatitis C virus (HCV) infection accounts for approximately 40% of chronic liver disease in the United States and results in an estimated 8,000-10,000 deaths annually. Simulations suggest that in the next decade morbidity and mortality associated with HCV infections will result in approximately …
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The role of scavenger receptor B-I in hepatitis C virus attachment and entry.
Hepatitis C Virus (HCV) poses a global health problem, leading to progressive disease often culminating in conditions such as hepatocellular carcinoma. HCV has a propensity to persist, with 70-80% of infected individuals failing to clear the virus. Recent evidence suggests that HCV entry is …
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In silico vaccine design for hepatitis C: A computational platform for fighting disease
Hepatitis C virus (HCV) infects 2-3% of the world's population. It is a major cause of liver morbidity and mortality and a scourge to global public health. Despite more than 20 years of research, only recently have effective treatments been developed and a vaccine remains elusive. The high cost of …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
Many individuals infected with hepatitis C virus (HCV) fail to respond to therapy, resulting in the development of chronic infection and increased risk for fibrosis, cirrhosis, and hepatocellular carcinoma. The current standard of care consists of pegylated interferon and ribavirin (RBV), a …
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Candidate Bivalent HCV Vaccine: A Novel Approach To Vaccine Design for Hyper-variable Viruses
… population is chronically infected with the hepatitis C Virus (HCV), and it estimated nearly 500,000 HCV related deaths will occur in 2020. Despite remarkable progress in treatment, the high number of occult infections, risk of reinfection following treatment, and the nearly 2 million new …
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EVALUATION OF THE HEPATIC MICROENVIRONMENT BEFORE AND AFTER ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C
Hepatitis C virus (HCV) infection remains a substantial global health burden, affecting millions annually despite recent therapeutic advances. Direct-acting antiviral (DAA) therapies have transformed clinical management, achieving cure rates exceeding 90% and significantly reducing complications …
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Drug resistance mechanisms and drug design strategies for human immunodeficiency virus and hepatitis c virus proteases
… treat the infections of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) which represent heavy public health burdens. The viral protease plays an indispensable role in viral maturation and therefore becomes one of the most important targets for drug design. Nine HIV-1 protease …
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Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
Hepatitis C Virus (HCV) infection represents a worldwide pandemic and is currently the leading cause of cirrhosis and liver transplantation. After transplantation recurrence is almost universal with 96% of patients testing positive for viral RNA and exhibiting histological evidence of infection …
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Characterizing B Cell Phenotype During Chronic HCV Infection
Chronic hepatitis C virus (HCV) infection is characterized by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several integrating correlates. We hypothesized that dysfunctions of antigen presenting …
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Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1
… between Huh7 subclones that are permissive for hepatitis C virus (HCV) replication versus the non-permissive parental Huh7 cells, we identified CREB3L1 as a host factor that inhibits proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, including murine …
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Understanding the assembly of simple ssRNA virus nucleocapsids
The assembly of simple ssRNA viruses from the initial interactions critical for nucleocapsid formation until the morphogenesis which occurs at each maturation stage of the virus’s “life” can entail a wide range of possibilities at every given stage. By whatever seeding event initiates the …
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Dissecting the Entry Pathways of Hepatitis C and Bovine Viral Diarrhea Viruses
<p>Hepatitis C virus (HCV) and bovine viral diarrhea virus (BVDV) are closely related members of the family Flaviviridae and are important human and animal pathogens, respectively. In this work, I investigated how these viruses interact with and enter both naïve and previously infected cells, …
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