Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"hepatic steatosis"”.
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The Association Between Hepatic Steatosis and Glucose Metabolic Dysfunction
… content, and that MCFA-induced NAFLD disrupts hepatic glucose metabolism through dysregulation of key glucose metabolic and insulin signaling pathways. Pigs (n = 6) were fed either MCFA or LCFA at high or low inclusion levels for 20 d in a 2 × 2 factorial design. Fractional body weight …
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The effects of exercise and omega-3 fatty acid supplementation as treatments for hepatic steatosis
… OLETF rats in part through increasing complete hepatic FAO, improving IS, and decreasing activation of the lipid synthesis pathway. Contrary to our original hypothesis, a diet moderately high in n3PUFAs failed to lower hepatic fat content and partially blunted the beneficial effects of exercise …
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Adiponectin deficiency leads to hepatic steatosis and contributes to the development of gestational diabetes mellitus
… sensitivity. Since adiponectin has a role in hepatic lipid metabolism, we hypothesize that adiponectin deficiency leads to fatty liver during pregnancy, worsening insulin resistance and contributing to GDM development. We compared adiponectin KO (strain B6;129-Adipoqtm1Chan/J) mice to WT …
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DEFINING THE ROLE OF LIPID DROPLET SCAFFOLDING PROTEINS IN HEPATIC STEATOSIS INDUCED BY HEPATITIS C VIRUS CORE PROTEIN
Hepatitis C Virus (HCV) is an enveloped RNA virus responsible for 170
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A study of the protective effects of an aspalathin enriched green rooibos extract on experimentally induced hepatic steatosis
… Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the metabolic syndrome, and is strongly associated with insulin resistance, obesity and type 2 diabetes (T2D). Growing evidence shows NAFLD as a multi-system disease, affecting several extra hepatic organs and regulatory …
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Cooperation between peroxisome proliferator activated receptor alpha and delta in regulation of body weight and hepatic steatosis in mice
… aim of the study was to characterise the hepatic transcriptional and lipid response of humanized mouse models to PPARd-agonists. <br/>In our studies of mice conditionally-expressing human PPARd (hPPARd), or the dominant-negative derivative of hPPARd (hPPARd?AF2) or wild-type animals, we …
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AAV9-mediated (Pro)renin Receptor Antagonism Reduces High Fat Diet Induced Hyperglycemia and Hepatic Steatosis in Mouse Model of Non-alcoholic Fatty Liver Disease
… PRR inhibition resulting in reprograming of hepatic lipid metabolism and consequently affecting diet-induced obesity and hepatosteatosis. In this study, we investigated the role of PRR activation in the mechanism of high fat diet (HFD)-induced fatty liver disease using a PRR antagonist, …
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REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5
… WE FOUND IT PROTECTIVE IN THE DEVELOPMENT OF HEPATIC STEATOSIS. MICE DEFICIENT IN MKP5 DEVELOPED HEPATIC STEATOSIS, WHICH WAS ASSOCIATED WITH INCREASED P38 MAPK ACTIVITY IN THE LIVER. FURTHERMORE, MKP5 REGULATES THE EXPRESSION OF CIDEA AND FSP27, TWO GENES IMPORTANT FOR THE DEVELOPMENT OF …
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Site and Mechanism of Leptin's Antisteatotic and Insulin Sensitizing Actions in Lipodystrophic Liver
… This is associated with insulin resistance and hepatic steatosis, which are corrected by leptin administration. This thesis aimed to define the site of leptin action and understand the molecular basis of leptin's insulin sensitizing and antisteatotic effects in lipodystrophy. To determine the …
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Investigating the impact of non-alcoholic fatty liver disease on the pathogenesis and progression of heart failure with preserved ejection fraction
… the aims of this thesis are to establish whether hepatic steatosis in itself is sufficient to detrimentally impact myocardial diastolic function, and to investigate mechanisms by which this might occur. In Chapter 3, the association between NAFLD and HFpEF is established in a murine model, …
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The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… complications such as insulin resistance and hepatic steatosis, a stage within the spectrum of Non-Alcoholic Fatty Liver Disease (NALFD). NAFLD is a common form of chronic liver disease that affects both adults and children. 10-20% of adults have hepatic steatosis, which is characterized by …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
… of both apoA-IV deficiency and overexpression on hepatic VLDL-mediated lipid efflux in two different mouse models of hepatic steatosis. Hepatic steatosis induced by either a high fat diet or enhanced de novo lipogenesis, caused by transgenic overexpression of a constitutively active form of …
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THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES
… or ezetimibe treatment has been shown to improve hepatic steatosis in rodents and humans without a defined mechanism. In the first project, we found that genetic inactivation of NPC1L1 in mice prevents high fat diet (HFD)-induced fatty liver by inhibiting hepatic de novo lipogenesis, at least in …
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INSIGHT ON ANGPTL3 IMPACT ON HEPATIC METABOLISM AND FUNCTION
… lipases has been well established, its effect on hepatic homeostasis and metabolism is still unclear. This work aims to unravel the autocrine effects of ANGPTL3 within the liver and its systemic impact on peripheral organs. The liver plays a key role in systemic metabolism, substrates management …
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The Role of Akt2 in Hepatic Lipid Metabolism
… of triglycerides in the liver, called hepatic steatosis, though the underlying pathogenesis of this accumulation remains unclear. There is certainly an inappropriate increase in de novo lipogenesis in the livers of individuals with hepatic steatosis, but the insulin signaling pathway …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… absorption can ameliorate the onset of hepatic steatosis. What I found was that in the early stages of disease onset, Ezetimibe prevents hepatic steatosis independently from the nuclear hormone receptor liver X receptor, and actually paradoxically stimulates hepatic lipogenesis despite …
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Cellular and Molecular Mechanisms Underlying Leptin's Metabolic Effects
… not downstream of the hormone's correction of hepatic steatosis. We next explored the proteomic and lipidomic modifications underlying the changes discussed above. Leptin-mediated changes in three components of the 1mitochondrial respiratory chain can account for the aforementioned metabolic …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY ARYL HYDROCARBON RECEPTOR
… (HFD)-induced obesity, insulin resistance and hepatic steatosis in mice. Recent studies suggest that PPARα expression is elevated with HFD feeding as an adaptive response to attenuate hepatic steatosis, and PPARa deficiency protects against HFD-induced insulin resistance. AhR-/- as well as AhR …
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Role of Ceramidase in Regulating Hepatic Lipid Metabolism and Whole Body Insulin Sensitivity
… disease that ranges histologically from simple steatosis in its mildest form to non-alcoholic steatohepatitis (NASH) in the more severe form, which is characterized by hepatocyte inflammation and fibrosis. In recent years, sphingolipids have garnered increasing attention for their role in the …
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