Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"hepatic glucose production"”.
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Gluconeogenesis as a system : development of in vivo flux analysis of hepatic glucose production in Type 2 Diabetes
… condition is characterized by deregulation of glucose homeostasis through the development of insulin resistance, manifested as increased glucose production in the liver. Hepatic gluconeogenesis provides de novo formation of glucose from three carbon precursors such as glycerol, lactate, …
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An Extensible Mathematical Model of Glucose Metabolism
… care dollars.</p> <p>One must understand the glucose regulatory system of the healthy body to understand diabetes. Blood glucose concentration returns to a constant level after eating and is maintained during exercise. With thousands of chemical reactions involved in the process, a complete …
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Die Interaktion zwischen dem Transkriptionsfaktor FoxO1a und der Proteinkinase DYRK1 und ihre Bedeutung bei der Regulation des Glucose-6-Phosphatasegens
… role of DYRK1 in insulin-dependent regulation of hepatic glucose-production was investigated. In different independent studies in liver cells a stimulatory effect of DYRK1 on glucose-6-phosphatase (g6pase) promoter activity was shown. An increased amount of endogenous g6pase-mRNA was found in …
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Flavonol kaempferol in the regulation of glucose homeostasis in diabetes
… mice. Oral administration of kaempferol improved glucose intolerance and insulin sensitivity, and this effect was associated with increased Glut4 and AMPKa expression in muscle and adipose tissues. Consistent with our findings from the in iii vitro study in C2C12 muscle cell line, these findings …
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Differentielle hepatische Genexpression in einem Mausmodell mit polygener Adipositas, Insulinresistenz und Hyperglykämie
… the differential expression of genes involved in hepatic glucose and lipid metabolism was studied. An outcross model of obese NZO mice with the lean SJL strain was established. NZOxF1 (SJLxNZO) backcross mice were generated in order to obtain a population with heterogeneous metabolism but …
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The Path to an Orally Administered Protein Therapeutic for the Treatment of Diabetes Mellitus
… to metabolic norms through direct effects on hepatic glucose production. The major problem facing oral delivery of protein therapeutics is gastrointestinal tract hydrolysis/proteolysis and the inability to passage the enterocyte. Herein we report the potential use of vitamin B<sub>12</sub> for …
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Mathematical modelling of blood glucose regulation
… to model the effects of exercise on the glucose regulatory system, for both healthy and diabetic individuals. A particular focus is given to the role of glucagon, whose role is often neglected in glucoregulatory models, and its ability to enhance hepatic glucose production and so to …
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Dipeptidyl Peptidase-4 in Cariometabolic Disease
… then performed to evaluate the role of DPP4 in hepatic steatosis, hepatic glucose production (HGP), inflammation and fibrosis, together with echocardiography to evaluate cardiac function. Genetic ablation of hepatocyte-derived DPP4 increased incretin hormone bioactivity in the portal vein, which …
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… to cause fasting hyperglycemia or elevated hepatic glucose output. In concordance with those findings we observed that dioxin treatment caused a strong suppression of the expression of the key hepatic gluconeogenic genes PEPCK and G6Pase. However, this suppression was not solely mediated by …
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Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… responses. One member, FGF19, causes reduced glucose and insulin levels with enhanced insulin sensitivity when expressed in transgenic mice. Another member, FGF21, has been shown to act as an insulin sensitizer pharmacologically by improving glucose tolerance and reducing insulin. The …
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The role of salt-inducible kinase in the control of hepatic gluconeogenesis
Regulation of hepatic gluconeogenesis by hormones insulin and glucagon is central to glucose homeostasis. Recent work has proposed that amongst the salt inducible kinase isoforms (SIK1, 2 and 3), members of the AMPK-related kinase family, the SIK2 isoform may play a role as signalling mediator in …
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The role of macrophage intracellular lipid partitioning in glucose and lipid homeostasis during obesity
… resistance, but had a minor benefitial effect on hepatic gene transcription during obesity. Chapter 4 develops on recent observations of interactions between sympathetic nerves and macrophages in WAT. In the first part of the chapter, I demonstrate that stimulating B2-adrenergic receptor (B2AR), …
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Small molecule kaempferol, a novel regulator of glucose homeostasis in diabetes
… 5 months (mo) improved insulin sensitivity and glucose tolerances, which were associated with increased Glut4 and AMPKα expression in muscle and adipose tissues in middle-aged mice fed a high-fat (HF) diet. In vitro, kaempferol increased lipolysis and restored chronic high fatty acid-impaired …
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Exploring the Grey Zone between Type 1 and Type 2 Diabetes
… resistance, which coexists with excessive hepatic glucose production and abnormal fat metabolism. Environmental factors causing insulin resistance are puberty, pregnancy, weight gain (central obesity “apple type”) and sedentary lifestyle. Usually T2D is diagnosed after 40 years of age and …