Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"hepatic gluconeogenesis"”.
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The role of salt-inducible kinase in the control of hepatic gluconeogenesis
Regulation of hepatic gluconeogenesis by hormones insulin and glucagon is central to glucose homeostasis. Recent work has proposed that amongst the salt inducible kinase isoforms (SIK1, 2 and 3), members of the AMPK-related kinase family, the SIK2 isoform may play a role as signalling mediator in …
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Influence of Homeorhetic State on Ruminant Metabolism and Substrate Selection for Hepatic Gluconeogenesis
… that the contribution of amino acids to hepatic gluconeogenesis would increase when glucose demand was increased in ruminants. Our first approach was to establish a sheep model for increased glucose demand. Four wethers injected with excipient or.5, 1.0, or 2.0 g/d of phlorizin excreted …
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ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3-kinase/Akt Signaling Post Burn Injury
Burn injury is a severe form of trauma that causes changes in glucose metabolism. Glucose metabolism is controlled during early burn injury but later results in stress induced diabetes. We have shown that this is due to differential regulation of the insulin signaling pathway in the liver.
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Dietary Protein Regulation of Insulin Sensitivity and Glucose Homeostasis
… disposal of dietary CHO and upregulating hepatic gluconeogenesis under fasted conditions.
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… due to promoting GLP-1 secretion and reduced hepatic gluconeogenesis. In addition, EA suppressed appetite, reduced food intake and gastric emptying rate, as well as promoted weight loss in obese mice, demonstrating that it is also an anti-obesity agent. Further, EA treatment reduced lipid …
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Gluconeogenesis as a system : development of in vivo flux analysis of hepatic glucose production in Type 2 Diabetes
… as increased glucose production in the liver. Hepatic gluconeogenesis provides de novo formation of glucose from three carbon precursors such as glycerol, lactate, pyruvate and alanine. The upregulation of this pathway underlies the persistent hyperglycemia observed in diabetic patients. We …
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Effects of Reduced Phenolic Acids on Ruminant Hepatic Metabolism
… All the reduced phenolics inhibited gluconeogenesis from propionate in bovine liver tissue at.4 mM and BA, PPA, and CA inhibited it at.2 mM. Oxidation of palmitate was inhibited by all the reduced phenolics (.2 mM) with 4OHPPA being least inhibitory. The reduced phenolics caused …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
… conjunction with Sirt1 modulating PGC-1&agr; in hepatic gluconeogenesis. With this information, it is logical to test if GCN5 also works with Sirt1 in the satellite cell response to muscle injury. The primary objective of this study is to determine the role of GCN5 and Sirt1 on Pax7-mediated …
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Dipeptidyl Peptidase-4 in Cariometabolic Disease
… then performed to evaluate the role of DPP4 in hepatic steatosis, hepatic glucose production (HGP), inflammation and fibrosis, together with echocardiography to evaluate cardiac function. Genetic ablation of hepatocyte-derived DPP4 increased incretin hormone bioactivity in the portal vein, which …