Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"hepatectomy"”.
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Albumin metabolism following partial hepatectomy in the rat
… aspects of albumin metabolism following partial hepatectomy in the rat. 1. The plasma albumin levels following partial hepatectomy. 2. The effect of partial hepatectomy on the albumin synthesis rate. 3. The effect of supplementary amino acids on the albumin synthesis rate following partial …
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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… of the liver following resection. After partial hepatectomy in mice, there is an increase in PI3K activity; total PI3K blockade with wortmannin, and selective inhibition of p85ƒÑ or p110ƒÑ with siRNA resulted in a significant decrease in hepatocyte proliferation, especially at the earliest …
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The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure
Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5. Earlier detection and intervention may improve outcomes. To date, no studies have …
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Blood Neutrophil-to-Lymphocyte Ratio predicts tumor recurrence in patients with hepatocellular carcinoma within Milan criteria after hepatectomy
… HCC patient confirming to Milan criteria after hepatectomy. Methods: Retrospective analysis was performed on a database of HCC patients who underwent hepatectomy between March 2001 and December 2011. The cutoff value of NLR was decided by receiver operating characteristic (ROC) curve analysis. …
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Manipulating macrophages to enhance liver regeneration
… mouse models of liver injury including partial hepatectomy, partial hepatectomy plus chronic liver injury and paracetamol intoxication. I show the development of liver function assays in these models including quantification of hepatic clearance of indocyanine green by fluorescent imaging and …
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Role of the IKK complex during liver regeneration
… in the context of liver regeneration. Partial hepatectomy (PH) in IKK2dhepa mice led to a delayed and reduced NF-kB activation. Consequently, the proinflammatory cytokine TNF-alpha was strongly induced earlier in IKK2dhepa mice and the Acute Phase Response marker SAA showed an early and strong …
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A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?
… the restoration of the liver mass after partial hepatectomy in rats.
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Analysis of factors influencing early outcome following liver resection
… mortality rate was 2.7% in patients without post-hepatectomy liver failure or renal dysfunction, 20% in patients with single organ dysfunction and 45% in patients with both. Post-operative serum lactate predicted the 90-day mortality rate (28% when post-operative lactate ≥6mmol/L compared to 0.7% …
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Cellular and molecular mechanisms of liver regeneration
… proliferation and liver regeneration. Partial hepatectomy was used as an experimental model of liver injury and regeneration. It was performed in mice, in which one or more αv integrins had been genetically depleted from specific cell types in the liver, namely hepatocytes, hepatic stellate …
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Genregulation des Zellzyklusmediators Cyclin E2 in humanen und murinen Hepatomzellen
… of mice segregated before and after partial hepatectomy showed furthermore that at least five protein-complexes bind cell cycle-dependent this highly-regulated sequence. In vitro-mutagenesis of the detected E2F-binding site surprisingly caused a higher promotor activity, which indicates an …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… that hepatocyte proliferation following partial hepatectomy (PH) can be attenuated by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that is involved in hepatic organogenesis and cell cycle control. This growth suppression suggests that AhR modulates critical …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
… liver regeneration. Two-thirds partial hepatectomy (PH) of mouse liver offers a unique model to compare p53 functions in regenerating versus sham (control) cells. My <strong>hypothesis</strong> is that intersection of global expression analyses (microarray and RNA sequencing) and …
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Cell cycle regulation in the liver : differential functions of E-type cyclins E1 and E2 for G1/S-phase transition and endoreplication in mice
… into the cell cycle in vivo. In the partial hepatectomy (PH) model it was shown that cyclin E1-/- deletion results in normal liver regeneration with slight delay of G1/S-phase transition but absent endoreplication in hepatocytes. In contrast, cyclin E2-/- mice showed over-expression of cyclin …
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Molecular analysis of the role of Caspase-8 during liver regeneration and tumorigenesis
… phase of liver regeneration following partial hepatectomy (PH) which directly contributes to gene activation of Cyclin D via NF-kappaB, c-Jun/ AP-1 and E2F1. The aim of the present study was to investigate the consequences of Caspase-8 deletion for TNF signaling during liver regeneration and …
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… (TCDD) following 70% partial hepatectomy (PH). One reported target of the AhR that may account for suppression of the regenerative response is plasminogen activator inhibitor-1 (PAI-1), which negatively regulates the cleavage and activation of hepatocyte growth factor (HGF) …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… surgical removal of ~2/3 of liver mass (partial hepatectomy, PH), the remaining hepatocytes exit G0 of cell cycle and undergo proliferation to reestablish liver mass. The hypothesis tested in this work is that p53/p73 functions in cell cycle arrest, apoptosis and senescence are repressed during …
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The Characteristics of Right Hepatic Vein in Middle Hepatic Vein Dominant Type, and the Variation of Glissonian Pedicle at Left Lobe of the Liver, Using Cadaver Liver Dissection
Introduction: Many liver resection and liver transplantation surgeries are performed worldwide, and clinical outcomes have recently improved. Studies of liver anatomy have developed alongside clinical and technical achievements as these types of research complement each other. I intended to …
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