Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 63 for “"hemostasis"”.
-
Polyphosphate modulates hemostasis, thrombosis, and inflammation
Polyphosphate (polyP) is a linear polymer of inorganic phosphates that is secreted by activated platelets and is abundant in many pathogenic microorganisms. Our lab has recently shown that polyP from bacteria and human platelets play important roles in inflammation and coagulation in vitro and in …
-
Evaluation of hemostasis in hyperthyroid cats
… unknown, but could be associated with altered hemostasis as seen in hyperthyroid humans. Objective: The purpose of this study was to evaluate markers of hemostasis in hyperthyroid cats compared to healthy cats, and in hyperthyroid cats before and after treatments with radioactive iodine (RIT). …
-
The Use of Synthetic Platelets to Augment Hemostasis
… the impact of targeting ligand concentration on hemostasis, and 3) test them in a clinically relevant porcine model of hemorrhage.Nanoparticle administration (GRGDS-NP1, 40 mg/kg) after lethal liver resection in the rat increased 1-hour survival to 80% compared to 40-47% in controls. Targeting …
-
Self-Assembling Peptide Nanofibers RADA16 and IEIK13 for Rapid Hemostasis
… mechanisms for RADA16 and IEIK13 to accelerate hemostasis by examining the effects on the activity of several clotting factors as well as effects on clot formation. While some effects on the activity of individual clotting factors were observed, in vitro testing using whole blood showed no …
-
A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
… a unique opportunity to study the mechanisms of hemostasis and thrombosis under physiologically relevant conditions. This thesis describes a microfluidic approach to model cardiovascular diseases and evaluate therapeutic candidates. In our studies, we recreated sterile occlusive thrombosis under …
-
Aspects of bleeding complications and hemostasis at central line insertion and mild induced hypothermia
Bleeding complications range from 0.5 to 1.6% in connection with central venous catheter insertions but are more frequent in patients with bone marrow failure and severe thrombocytopenia. Although supportive evidence is scarce, prophylactic platelet transfusion is sometimes performed in these …
-
Infusing Factor Viii-Expressing Platelets Or Megakaryocytes As A Novel Therapeutic Strategy For Hemophilia A
… of platelets and is capable of restoring hemostasis in FVIIInull mice, even in the presence of circulating inhibitors. pFVIII has been proposed to be used for gene therapy for patients with hemophilia A, intractable inhibitors, and life-threatening bleeds. However, prior studies by us have …
-
Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
Current in vitro or ex vivo models of hemostasis and thrombosis fail to recapitulate the hemodynamic conditions and biorheologic phenomena found throughout the vasculature. Microfluidic technology enables physiologic hemodynamics for the study of platelet deposition and coagulation using minimum …
-
Evaluation of the Harmonic Scalpel for Laparoscopic Bilateral Ovariectomy in Standing Horses
… to transect the ovarian pedicle and to obtain hemostasis simultaneously. Necropsy was performed on 4 mares 3 days after surgery and 30 days following surgery on the remaining 4 mares. Gross and histopathologic evaluation of the ovarian pedicles was performed to characterize the effects of the …
-
THROMBUS GENERATION UNDER FLOW CONDITIONS IN PATIENTS WITH CIRRHOSIS AND THROMBOCYTOPENIA: THE CIRTAS-STUDY
… risk remains uncertain due to a rebalance of hemostasis. Traditional coagulation tests, such as platelet count, prothrombin and activated thromboplastin time, fail to capture the complex interplay of pro- and anti-hemostatic mechanisms and do not reliably predict the bleeding risk in …
-
Studies on formation and stabilization of pathological thrombi in vivo
… in thrombus growth is essential for normal hemostasis, but can lead to irreversible, life-threatening vessel occlusion. In the current study, the contribution of platelet integrins, activation receptors and the contact system of blood coagulation in such pathological conditions was …
-
Mechanistic Investigation of A Hemostatic Keratin Biomaterial
… signaling pathway, specifically contributing to hemostasis. Through application of biochemical and molecular tools, we demonstrate here that keratin biomaterials contribute to hemostasis through two probable mechanisms; integrin mediated platelet adhesion and increased fibrin polymerization.
-
Fibrin Formation and Dissolution in the Progression of Amyloid-Beta Pathology in Alzheimer's Disease
… cerebral vasculature is damaged, and abnormal hemostasis is present. Circulatory deficiencies could therefore play an important role in the pathogenesis of this disease. We found an increase in blood brain barrier (BBB) permeability and neurovascular damage in AD mice, and showed that fibrin …
-
Peripheral Leukocytes and Intracerebral Hemorrhage
… that are mechanistically associated with hemostasis failure or cerebral edema would provide direction for exploring therapeutic targets, and identify patients in need of hemostatic or anti-inflammatory therapy.Peripheral white blood cell (WBC) count has been associated with hemorrhage …
-
Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
… a multimeric protein that has a central role in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF multimers due to genetic …
-
Single Fibrin Fiber Mechanical Properties and Lysis
… in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the …
-
Applications of blood biomarkers of traumatic brain injury across the severity spectrum---a focus on pathophysiological mechanisms
… activity, inflammation, vascular injury and hemostasis. RESULTS. In moderate-to-severe TBI, we found significant, dynamic pathological associations between SNS hyperactivity, inflammation, hemostasis, and vascular injury. In SRC, we found subacute alterations to numerous peripheral indices of …
-
Identification of Multiple Levels of Trauma Induced Coagulopathy
… shift, platelets have become a central player in hemostasis. Unfortunately little is currently understood about how platelet function is affected by trauma. In an effort to better define platelet function during trauma and the resulting shock from exsanguination, a multipronged approach was …
-
Potential sources for the large scale production of human protein C
… in the liver and act to maintains normal hemostasis. such as properly regulated clotting. An imbalance of any of these pro- or anti-clotting proteins result in hemophilia or disseminated intravascular clotting diseases. Therefore, these proteins have a significant therapeutic value. Many …
Page 1 of 4