Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"hemorrhagic fever"”.
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Vaccine Development Strategies for Crimean-Congo Hemorrhagic Fever Virus and its Tick Vector
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus with an extensive geographic range and complex ecology. Ticks within the Hyalomma genera are the primary vector and reservoir of the virus and maintain the virus through a cryptic tick-vertebrate-tick cycle in nature. However, …
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Studying the biology of, and developing countermeasures to, a tick-transmitted hemorrhagic fever virus
Crimean-Congo hemorrhagic fever (CCHF) is one of the world’s most medically relevant tick-borne viral diseases. The CCHF virus (CCHFV) is transmitted in seasonal cycles among ticks and animals and is endemic to the Eastern hemisphere. Severe disease may develop with outbreak case fatality rates up …
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Using the host immune response to hemorrhagic fever Viruses to understand pathogenesis and improve diagnostics
Hemorrhagic fever viruses cause severe infections characterized by a hyperactive immune response that often leads to multiorgan failure and death. Current diagnostic tests are based on detecting viral proteins and nucleic acids in the blood. These are late-stage events during infection, which makes …
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Discovering LC3-interacting region (LIR) motifs in hemorrhagic fever viruses: Implications for host autophagy and viral replication.
Hemorrhagic fever viruses (HFVs) pose significant global health and economic burdens, yet limited FDA-approved therapeutics exist to combat their spread. Determining alterations in host processes during infection can enhance our understanding of viral replication and lead to potential host-based …
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The production of a Crimean-Congo haemorrhagic fever virus diagnostic antigen in plants
Crimean-Congo Hemorrhagic Fever (CCHF) is a highly infectious, life threatening disease, caused by the Crimean-Congo Hemorrhagic Fever Virus (CCHFV), a nairovirus that forms part of the Bunyaviridae family. CCHFV has a case fatality rate of approximately 40%. Current diagnostic methods for CCHFV …
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Papel de las aves en la dispersión de garrapatas y microorganismos que vehiculan
… and Spiroplasma) and viruses (Crimean-Congo hemorrhagic fever virus, Flavivirus, Phlebovirus, Coltivirus and Orbivirus) using molecular biology techniques. In these studies, ticks belonging to five species (Haemaphysalis punctata, Hyalomma marginatum, Ixodes arboricola, Ixodes frontalis and …
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Immunoepidemiological Modeling of Dengue Viral Infection
… heterologous infections, resulting in dengue fever and dengue hemorrhagic fever. The contribution to overall killing, however, is dominated by non-specific T cell responses during the majority of secondary dengue hemorrhagic fever cases. By contrast, more than half of secondary dengue fever …
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The development of a reverse genetics system for Machupo virus
The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV), is a highly lethal viral pathogen with no approved vaccine or therapeutic to limit infection or outbreaks. Following implementation of rodent population controls after the initial outbreak, no cases of BHF were reported …
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Investigations into endothelial cell permeability and adherens junction disruption induced by Junín virus infection.
… Junín is the causative agent of Argentine hemorrhagic fever (AHF) characterized by vascular dysfunction and fluid distribution abnormalities. Clinical, as well as experimental studies, have implicated involvement of the endothelium in pathogenesis of AHF, although the role it may play is …
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Studies on the antibody repertoire in a Dengue virus immune subject and isolation of neutralizing antibodies by phage display technology
… (DENV) is known as the causative agent of Dengue Fever and Dengue Hemorrhagic Fever / Dengue Shock Syndrome (DHF/ DSS). Infection with one of the serotypes elicits long-term, homotypic protection but does not protect from the risk of development of DHF/DSS upon subsequent infection with other …
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Exogenously-introduced Homing Endonucleases Catalyze Double-stranded DNA Breaks in Aedes aegypti
… aegypti transmits the viruses which cause yellow fever, dengue fever, and dengue hemorrhagic fever. Homing endonucleases are selfish genetic elements which introduce double-stranded DNA (dsDNA) breaks in a sequence-specific manner. In this study, we aimed to validate a somatic assay to detect …
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Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… diseases West Nile encephalitis or Dengue hemorrhagic fever. As members of the same genus, they share many important biological features including a highly homologous NS3 protease. NS3 is essential for virion replication, making it an ideal target for a broad-spectrum inhibitor of the …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
… that is the causative agent of Argentine hemorrhagic fever (AHF). AHF resulted in 15-20% case fatality during epidemics until the introduction of a vaccine that drastically reduced the incidence of the disease. This live-attenuated vaccine, Candid#1 (Can), contained many amino acid …
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Dengue Virus Host Factors
<p>Dengue fever and dengue hemorrhagic fever are estimated to afflict 50-100 million people annually and are caused by one of the four serotypes of dengue virus. Dengue virus is carried and transmitted to humans by mosquitoes of the Aedes genus. Given the broad geographic distribution of Aedes …
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Biophysical Characterization of the vOTU Proteases from the CCHF and Dugbe Nairoviruses
… specificities. The vOTU from the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) has been implicated in the down-regulation of the innate immune response through its ability to cleave post-translational modifications via Ubiquitin (Ub) as well as the Ub-like interferon-stimulated gene 15 (ISG15). …
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Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
… are viruses that can cause severe and deadly hemorrhagic fever infections in Africa and South America, including Lassa virus that causes Lassa fever in several countries in west Africa. There are currently no vaccines and very limited therapeutics available for Lassa fever. There are also …
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Efektifitas estrak etanol rimpang alang-alang (mperta cylinca) sebagai larvasida nyamuk (Aedes aegypti L) instar III
… digestivus dan eksosekeleton. ENGLISH: Dengue Hemorrhagic Fever (DHF) is one of the communicable diseases that pose a serious threat to public health in the world. Aedes aegypti is a disease vector mosquito which belongs to a class of insects. Eradication of Aedes aegypti with the termination …
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Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes significant morbidity and mortality in both humans and animals. In humans, the disease manifests itself as febrile illness, hemorrhagic fever, encephalitis, or retinitis. In animals, RVFV causes high rates of abortions and fetal …
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Thioaptamers Targeting Dengue Virus Type-2 Envelope Protein Domain III
… types 1-4, West Nile virus, Langat virus, Omsk hemorrhagic fever virus and others that cause encephalitic or hemorrhagic disease. DENV binds the cell surface receptors and fuses with the host cell membrane using surface envelope protein (E). The E protein ectodomain contains three domains, EDI, …
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Mechanisms of attenuation of the live Junin virus vaccine strain, Candid #1
… virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is currently the only pathogenic arenavirus for which a vaccine is currently in use. The Candidate #1 (Candid #1) vaccine strain, which was obtained from the 44th mouse brain passage of the parental XJ strain, has …
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