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Showing 1 to 3 of 3 for “"hemoglobin degradation"”.
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Biochemical Characterization of Two Aminopeptidases Involved in Hemoglobin Catabolism in the Food Vacuole of Plasmodium falciparum
… of proteases degrade a majority of the host hemoglobin. Two metalloaminopeptidases, PfAPP and PfA-M1, have been previously localized to the food vacuole (in addition to distinct secondary locations for each), implicating them in the final stages of hemoglobin catabolism. Prior genetic work …
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Systematic Survey of the Plasmodium falciparum Hemoglobin Catabolic Pathway in Intact Cells Using the Digestomics Approach
Hemoglobin (Hb) catabolism is an essential component of Plasmodium parasites’ intraerythrocytic asexual reproduction cycle. This catabolic process has been extensively studied over the past six decades as a potential target for antimalarial drugs. The current model describes Hb proteolysis as a …
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Synthesis, biological activity and physicochemical properties evaluation of antiplasmodial pyrimido[1,2-a]benzimidazoles
… potential of the compounds to target the host hemoglobin degradation pathway in an analogous manner to the related PBI derivatives, compounds were also evaluated in the synthetic hemozoin, beta-hematin inhibition (βHIA) assay. Aqueous solubility, and for selected compounds, microsomal metabolic …