Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"hemiasterlin"”.
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The Use of C. Elegans to Identify Mutations That Confer Drug Resistance, Using Hemiasterlin as an Example
Hemiasterlin is a natural product isolated from the several species of marine sponges. Hemiasterlin inhibits microtubule polymerization resulting in cell cycle arrest and apoptosis. Cells over-expressing efflux pumps associated with multidrug resistance are not resistant to the toxic effects of …
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Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
… wider range of PPIs. 2) Novel total synthesis of hemiasterlin and its use as a payload in antibody–drug conjugates (ADCs). This thesis details the novel synthesis of hemiasterlin, an anti-mitotic marine natural product with low- to sub-nM potencies against several cancer cell lines. Rapid …