Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"heme synthesis"”.
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Investigating inhibition of porphyrin (heme) synthesis as a novel treatment option for prostate cancer
… cancer cells. It has been shown that porphyrin synthesis is increased in multiple cancers and targeting this pathway may be a viable treatment option for PC. Crystal violet assays demonstrated that the porphyrin synthesis inhibitor succinyl acetone (SA) reduced the proliferation of PC3, LNCaP …
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The development of a novel therapeutic strategy for the treatment of prostate cancer by targeting metabolic signalling
… in essential pathways including lipogenesis, heme-biosynthesis, redox homeostasis, and glycolysis. The lead targets were validated in a range of cell lines and additional assays performed to investigate the effect upon cell cycle and cell death. UROS, the fourth step of heme synthesis, was …
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
… screen identified that loss of genes in the heme synthesis pathway renders mouse BCR-ABL+ B-ALL cells resistant to DHA-induced death. Mechanistically, DHA disrupts the interaction between heme and the eIF2α kinase heme regulated inhibitor (HRI) triggering the integrated stress response. …
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Characterization of the Hepatotoxicity of Rifampicin and Isoniazid
… of protoporphyrin ix (PPIX), the penultimate heme precursor. Excess PPIX is believed to bind to bile acids, precipitate in bile canaliculi, and form bile plugs leading to cholestasis fol owed by liver injury. Both ferrochelatase (<em>FECH</em>/<em>Fech</em>) and aminolevulinic acid synthase 1 …
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Molecular Mechanisms Underlying Aerobic Respiration and Heme Regulation in Yeast
Heme is an important signaling molecule with diverse functions in living organisms ranging from regulating gene transcription to circadian rhythm. In yeast, heme serves as a secondary messenger of oxygen, as heme synthesis depends on the intracellular levels of oxygen. Yeast and higher eukaryotes …
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Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways
… discovery more than twenty years ago that the heme-synthesis enzyme ä-aminolevulinic acid dehydratase (ALAD) possesses proteasome inhibitory activity revealed another potential approach for targeting the UPP in cancer. However, this discovery predated the initial investigation into proteasome …
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Investigating the effect of a Mycobacterium tuberculosis inhA promoter mutation in cell envelope composition and morphology
… drugs respectively that target mycolic acid (MA) synthesis. MA are characteristic components of mycobacterial species’ cell wall and contribute to the impermeability of cell wall by virtue of its hydrophobicity. IPMs result in a transcriptional upregulation of inhA, and mabA, which are genes …
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… 1 (CHP1) as a major regulator of ER glycerolipid synthesis and saturated lipid toxicity. Mechanistically, CHP1 binds and activates GPAT4, which catalyzes the initial rate-limiting step in glycerolipid synthesis. GPAT4 activity requires CHP1 to be N-myristoylated, forming a key molecular interface …
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An Intermediate Heme Threshold is Necessary for the Activation of the Stress Response and Redox Homeostasis in Yeast
… we reveal that an intermediate threshold of heme biosynthesis is sufficient to activate the stress response and maintain mitochondrial redox homeostasis but not mitochondrial respiration. In the first result Chapter (Chapter 3), using the hem1∆ mutants supplemented with different …