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Showing 1 to 20 of 43 for “"heme oxygenase"”.
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Induction of Heme Oxygenase By a Carbon Monoxide-Releasing Molecule
We have recently demonstrated that heme oxygenase is expressed in both healing wounds and in pressure ulcers. Heme oxygenase has been shown to have important cytoprotective functions in myocardial ischemia-reperfusion injury and organ allograft survival. The cytoprotective effects of heme oxygenase …
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
In the past few years, heme oxygenase (HO) has been regarded as a potential pharmacological target, especially the inducible isoform, heme oxygenase-1 (HO-1). HO catalyzes the rate-limiting step of endogenous heme degradation, releasing carbon monoxide (CO), free iron (Fe2+), and biliverdin (BV), …
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Upregulation of heme oxygenase-1 and activation of Nrf2 by the phytochemicals in protandim
… enzymes, including the endogenous antioxidant heme oxygenase-1 (HO-1), with activation of nuclear factor E2 p45-related factor 2 (Nrf2), and protection from oxidative stress induced apoptosis. In cultured cardiomyocytes, treatment with Protandim was associated with activation of Nrf2 and a …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… HAND and reduced protein expression of brain heme oxygenase-1 (HO-1), a highly inducible detoxifying enzyme with antioxidant and anti-inflammatory functions. We further demonstrated that HIV infection of macrophages reduces HO-1 RNA and protein and that this HO-1 loss is associated with …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… chronic inflammation, and oxidative stress. Heme oxygenase-1 (HO-1) is a highly inducible, detoxifying enzyme critical for limiting oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and other tissues. Our analysis of HO-1 expression in the brain …
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Discovery and characterization of a set of peptide-modifying heme oxygenase-like domain-containing oxidases
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
Hämoxygenase-1 (HO-1) ist das Schlüsselenzym, das den Abbau von Häm zu Carbonmonixid (CO), zweiwertigem Eisen (Fe2+) und Biliverdin katalysiert. Wegen der facettenreichen anti-entzündlichen Wirkweisen dieser Produkte, wurde vorgeschlagen daß HO-1 in der Akuten-Phase Reaktion, der Abwehrreaktion des …
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Heme Oxygenase-2 as a novel target to treat inflammation and chronic neuropathic pain associated with corneal injury and surgery
… response. Among these mechanisms, the heme oxygenases systems seem to play a major role. In the recent years the heme oxygenase system (HO-1 and HO-2) has emerged as a fundamental endogenous cytoprotective and anti-inflammatory system in many tissues. It is readily upregulated in …
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Synthesis and Evaluation of Naturally Occuring Halogenated Bipyrroles in a Relevant Marine Species, Fundulus Heteroclitus
… on examining the effects of HDBP's to inhibit heme oxygenase (HO), the enzyme responsible for the catalytic oxidation of heme, which may account for the accumulation of porphryrins in hepatocyte models. Within the current study we have synthesized and characterized several natural product …
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Early Mediators of Cutaneous Ischemia Reperfusion Injury: A Mouse Model
… associated with these wounds, a unifying theme has been proposed to be the repetitive incidence of ischemia reperfusion injury.A mouse model of cyclic ischemia reperfusion was employed to examine the initiation events in the pathology of chronic wounds. Mice were subjected to eight hours of …
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Biliverdin reductase in cardiovascular inflammation
… Reductase (BVR) functions downstream of Heme Oxygenase 1 (HO-1) in the process of heme degradation and catalyses the reduction of biliverdin to bilirubin. For over thirty years, BVR was regarded as rather a trivial enzyme whose only known function was to aid heme disposal. Over the last …
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Oil palm phenolics suppresses oxidative stress and inflammation
… protein expression of activated enzymes such as Heme Oxygenase 1. An image analysis assay was developed to study the effects of OPP on cell size, morphology and phagocytosis of Lipopolysaccharides (LPS) induced inflammation in BV-2 microglial cells. This study was followed by experiments to …
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Cellular uptake and actions of bilberry anthocyanins in retinal pigment epithelial cells
… the oxidative stress protective enzymes heme oxygenase-1 (HO-1) and glutathione S-transferase (GSTP1) proteins in RPE cells by 1.5- to 2-fold over untreated cells in 6 hours and, at pharmacologic doses, up-regulate HO-1 as much as 10-fold over a 24-hour period. Bilberry anthocyanins and …
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Targeting Nrf2 in Inflammation and Cancer
… it was a much more powerful activator of heme oxygenase-1 than any diallyl sulfides reported to date. Nrf2 is regulated by Keap1, which targets it for degradation. Disruption of the Nrf2/Keap1 interaction results in Nrf2 activation. In this study, a novel cell-penetrating peptide, based on …
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Evaluation of Carbon Monoxide as a Therapeutic for Preeclampsia
… CO is produced through the degradation of heme by heme oxygenase (HO), and it has been suggested that modulation of the HO/CO system may attenuate the development or progression of PE. The studies presented herein demonstrate that low doses of CO, delivered through gaseous CO or CO donor …
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Mechanisms of Macrophage Detection and Control of Mycobacterium tuberculosis Infection
… of the carbon monoxide producing enzyme heme oxygenase (HO1) in the macrophage and that the CO is sensed by M. tuberculosis to initiate a dormancy program. Mice deficient in HO1 succumb to M. tuberculosis infection more readily than wild-type (WT) mice. While the mechanisms used by mouse …
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Cerebral Amyloid Angiopathy and Transition Metals in Alzheimer's Disease
… with CAA is accompanied by increased levels of heme degradation enzymes, heme oxygenase and biliverdin reductase. Finally, because the mechanism(s) underlying vascular fragility in CAA is unknown, we evaluated the role of terminal complement on cerebrovascular elements in the setting of CAA. …
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Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
… of cGMP could be demonstrated. The induction of heme oxygenase-1 by ANP might not be responsible for the observed hepatoprotection, since inhibition of HO-1 activity did not abrogate the ANP effect. Interestingly, cell-type specific evaluation detected that induction of HO-1 in livers by ANP is …
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