Global ETD Search

The amelioration of transplantation associated ischaemia reperfusion injury by the novel heme oxygenase-1 inducer heme arginate

Beesley, Matthew FrederickThe University of Edinburgh2014

edinburgh Repository record for The amelioration of transplantation associated ischaemia reperfusion injury by the novel heme oxygenase-1 inducer heme arginate (opens in a new tab)

HOT study: the development, management and results from phase IIB, randomised controlled trial of heme arginate in recipients of deceased donor renal transplants

Thomas, Rachel Alexandra BarclayThe University of Edinburgh2016

… a transplanted kidney. One enzyme of interest, heme oxygenase-1 (HO-1), degrades heme and protects against the oxidative stress that occurs secondary to IRI. Clinical renal recipients with higher HO-1 levels have improved graft function post transplant. Heme arginate (HA), a form of hemin, which …

edinburgh Repository record for HOT study: the development, management and results from phase IIB, randomised controlled trial of heme arginate in recipients of deceased donor renal transplants (opens in a new tab)

MicroRNAs as biomarkers of injury and drug response in renal transplantation

Connor, KatieThe University of Edinburgh2022

… demonstrated the beneficial properties of heme oxygenase-1 (HO-1) upregulation on ischaemia reperfusion injury (IRI). Heme arginate has previously been shown to safely upregulate HO-1 in renal transplant recipients (HOT study) and this formed the basis for the multi-centre trial assessing …

edinburgh Repository record for MicroRNAs as biomarkers of injury and drug response in renal transplantation (opens in a new tab)