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Showing 1 to 20 of 419 for “"heme"”.
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De Novo Heme Protein Design
"We have developed an interesting hypothesis for Olfactory Receptor (OR) mechanism. We are so sensitive to thiols and amines that the most natural way to explain this is that OR is a metalloprotein. We have found a consensus sequence ""HXXCE"" in the 4--5 loop of ORs, which not only binds strongly …
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Ligand Binding by Heme Proteins
Made available in DSpace on 2014-12-14T04:27:34Z (GMT). No. of bitstreams: 1 7606765.pdf: 4038449 bytes, checksum: 62e351e5367503c1cb5b9b986afaa009 (MD5) Previous issue date: 1975
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Optical Activity of Heme Proteins
Made available in DSpace on 2014-12-09T17:36:48Z (GMT). No. of bitstreams: 1 7020980.pdf: 4514168 bytes, checksum: a60db275abc5a904f1eeaaef57d9023a (MD5) Previous issue date: 1970
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Molecular tunneling in heme proteins
Submitted by Carolyn Mead (cmead2@illinois.edu) on 2011-06-27T15:50:04Z No. of bitstreams: 1 1980_reynolds.pdf: 1707453 bytes, checksum: d6a10b7efebee8db106a192f8706c7b8 (MD5)
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Relaxation dynamics in heme proteins
… pressure change are studied in carbonmonoxy (CO) heme proteins (myoglobin-CO, substrate-bound and substrate-free cytochrome P450cam-CO, chloroperoxidase-CO, horseradish peroxidase-CO) between 150 K and 250 K using FTIR spectroscopy to monitor the CO bound to the heme iron. Two types of prelaxation …
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Relaxation dynamics in heme proteins
A protein molecule possesses many conformational substates that are likely arranged in a hierarchy consisting of a number of tiers. A hierarchical organization of conformational substates is expected to give rise to a multitude of nonequilibrium relaxation phenomena. If the temperature is lowered, …
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Interactions Between Heme-Globins and Ligands
Neuroglobin (Ngb) is a hexacoordinated heme protein closely related to the pentacoordinated hemoglobin (Hb) and myoglobin (Mb) and in the central and peripheral nervous systems with expression in some endocrine tissues.1–5 Ngb is believed to play roles in: sustaining ATP production under anaerobic …
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Heme protein structure and ligand binding
Binding of carbon monoxide to a variety of heme proteins is a multistep process and can be described by a sequence of activation barriers. In the separated alpha and beta chains of hemoglobin three barriers are found which are sensitive to the structural differences between the two chains. The …
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Enhance heme biosynthesis in Saccharomyces cerevisiae
This research delves into the enhancement of heme production in Saccharomyces cerevisiae through Adaptive Laboratory Evolution (ALE) and Atmospheric and Room Temperature Plasma (ARTP) mutagenesis, complemented by strategic nutrient supplementation. Despite the theoretical promise of ALE and ARTP to …
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Evolutionary and Paleobiochemical Analyses of Heme Peroxidases
… The approach presented here, applied to the heme peroxidases, marries bioinformatic methods with evolutionary theory and biochemical validations. Heme peroxidases catalyse the oxidation of a variety of electron donors by hydrogen peroxide. These enzymes can be classified into two major …
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Active Site Labeling Studies on Heme Proteins
Made available in DSpace on 2014-12-10T23:01:07Z (GMT). No. of bitstreams: 1 7115008.pdf: 6243868 bytes, checksum: 84013bd36efc9681752aafc04ee3ad77 (MD5) Previous issue date: 1970
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Exploring the Roles of Heme Type and Histidine -Tyrosine Cross -Link in Heme-Copper Oxidases Using a Myoglobin Model
… the CuBMb model in this study: (1) synthetic heme cofactors are used to replace the natural one of the protein, resulting in ∼20 fold inhibition of the side reaction; (2) a novel semi-synthetic system (Expressed Protein Ligation) is also established that may introduce new features such as …
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Metal complexes of non-heme ligands: biological applications
… trypsin, chymotrypsin and 20S proteasome) by non–heme iron complexes, and glutathionylation of non–heme cobalt complexes mimicking the N5 coordination environment like that of biologically important cofactor cobalamin or B<sub>12</sub> (Cbl) are reported. Different non–heme ligand sets or …
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A Free Heme Perspective to Sickle Hemoglobin Polymerization
… towards the polymerization event. The free heme, prosthetic group of hemoglobin, is one such small molecule which has been previously shown to enhance the polymerization by orders of magnitude and removal of free heme from the supersaturated HbS solution stops the polymerization completely. …
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Magneto-optical spectroscopic studies of multi-heme enzymes
Cytochrome cd1 (cd1) is a soluble, diheme enzyme located in the periplasm of denitrifying bacteria that catalyses the one-electron reduction of nitrite ion to nitric oxide. Paracoccus pantotrophus cd1 undergoes an unusual coordinated ligand switch upon reduction to the diferrous state, whereby a …
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Magneto-optical spectroscopic studies of multi-heme enzymes
Cytochrome cd1 (cd1) is a soluble, diheme enzyme located in the periplasm of denitrifying bacteria that catalyses the one-electron reduction of nitrite ion to nitric oxide. Paracoccus pantotrophus cd1 undergoes an unusual coordinated ligand switch upon reduction to the diferrous state, whereby a …
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Examining the Proton Channels in Heme -Copper Oxidases
Previous work on the mutant enzyme KI-362M indicated that a block in the K-channel would result in the blockage of the catalytic cycle between the oxidized state and the two electron reduced state. This blockage occurs because an electron cannot enter the binuclear center without a proton to …
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General Features of Ligand Binding to Heme Proteins
The binding of ligands to heme proteins has been studied extensively in the past. A sequential barrier model was postulated. Using flash photolysis, various aspects of the model are studied in this work to give a better understanding of ligand binding. Binding from the pocket, as seen at low …
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Synthetic Iron Porphyrins as Models for Heme Proteins
… been studied as models for the active sites of heme proteins. Spectroscopic studies of (FeTPP)(,2)N('+) (where TPP is the dianion of tetraphenylporphyrin) and (FeTPP)(,2)C indicate that these complexes contain iron(IV). This behavior can be contrasted with the isoelectronic complex …
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